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LIMK2

  • Official Full Name

    LIM domain kinase 2

  • Overview

    LIM kinases (LIMK1 and LIMK2) are serine/threonine kinases that have two zinc finger motifs, known as LIM motifs, in their amino-terminal regulatory domains (1). LIM kinases are involved in actin cytoskeletal regulation downstream of Rho-family GTPases, P
  • Synonyms

    LIMK2; LIM domain kinase 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Mammalian Cell
  • Sf21
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LIMK2-125H Active Recombinant Human LIMK2(2-end) Protein, N-His-tagged Sf21 His 2-end
Human LIMK2-382H Recombinant Human LIMK2 Protein, GST/His-tagged E.coli GST/His
Human LIMK2-4737HCL Recombinant Human LIMK2 293 Cell Lysate HEK293 N/A
Human LIMK2-4738HCL Recombinant Human LIMK2 293 Cell Lysate HEK293 N/A
Human LIMK2-5545H Recombinant Human LIMK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human LIMK2-4132HF Active Recombinant Full Length Human LIMK2 Protein, GST-tagged Insect (sf21) GST 1-638
Mouse LIMK2-9109M Recombinant Mouse LIMK2 Protein Mammalian Cell His
Mouse LIMK2-5086M Recombinant Mouse LIMK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse LIMK2-5086M-B Recombinant Mouse LIMK2 Protein Pre-coupled Magnetic Beads HEK293
Rat LIMK2-3412R Recombinant Rat LIMK2 Protein Mammalian Cell His
Rat LIMK2-3068R Recombinant Rat LIMK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat LIMK2-3068R-B Recombinant Rat LIMK2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish LIMK2-761Z Recombinant Zebrafish LIMK2 Mammalian Cell His
Chicken LIMK2-6672C Recombinant Chicken LIMK2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LIMK2 Related Articles
  • LIMK2 Related Signal Pathway

LIMK2 involved in several pathways and played different roles in them. We selected most pathways LIMK2 participated on our site, such as Axon guidance, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIMK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceNRG2A;MAPK1;SCN4A;DUSP10;GPC1A;SEMA5A;HBEGF;RASGEF1A;RHOAE
Fc gamma R-mediated phagocytosisVAV2;WASL;GSN;INPP5D;MYO10;MAP2K1;FCGR2B;PIP5K1C;PLCG2
Regulation of actin cytoskeletonRHOAC;PFN3;ARHGEF4;PIP5K2;DIAPH3;ITGA6B;RRAS2;ITGAE;FGF11

LIMK2 has several biochemical functions, for example, ATP binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LIMK2 itself. We selected most functions LIMK2 had, and list some proteins which have the same functions with LIMK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingROCK2A;CKMT1A;ABCB6A;DCK;KIF3B;GALK2;MTPAP;PSKH2;DYRK4
protein bindingDCP2;EVI5;POLE3;LAMP2;LENG1;NRG1;CNKSR3;DNMT3A;ID2
protein heterodimerization activityABCG1;HIST1H2BP;ALX4;TCF3A;TAF6L;RELA;HIST1H3G;SEPHS1;HIST1H2AA
protein serine/threonine kinase activityMAP4K6;PRKCD;RIPK4;HIPK3;NLK1;STK33;PDK3;TLK1B;PIK3R4
zinc ion bindingHNF4A;ZFP326;ZNF331;THAP11;MKRN4;TRIM38;MLL5;LIMS3L;USP13

LIMK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIMK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LIMK2.

HSP90AB1; CDC37; PARD3; q5ngc7_fratt; HIPK3; linkable pd173955 analogue; bosutinib; crizotinib; CALU; DNAJA2; BAG2; LMNA; HSPB1; ATP1A1; CDK4; EEF2; HSP90B1; DNAJA1; EMD

Acevedo, K; Moussi, N; et al. LIM kinase 2 is widely expressed in all tissues. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 54:487-501(2006).
Foletta, VC; Moussi, N; et al. LIM kinase 1, a key regulator of actin dynamics, is widely expressed in embryonic and adult tissues. EXPERIMENTAL CELL RESEARCH 294:392-405(2004).
Toshima, J; Ohashi, K; et al. Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells. JOURNAL OF BIOLOGICAL CHEMISTRY 270:31331-31337(1995).
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