LIN28A
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Official Full Name
lin-28 homolog A (C. elegans)
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Overview
Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. -
Synonyms
LIN28A; lin-28 homolog A (C. elegans); CSDD1; LIN28; LIN-28; ZCCHC1; lin-28A; protein lin-28 homolog A; RNA-binding protein LIN-28; zinc finger, CCHC domain containing 1; zinc finger CCHC domain-containing protein 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Yeast
- Arg
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- FLAG
- TAT
- Involved Pathway
- Protein Function
- Interacting Protein
- LIN28A Related Research Area
LIN28A involved in several pathways and played different roles in them. We selected most pathways LIN28A participated on our site, such as Cardiac Progenitor Differentiation, Developmental Biology, Transcriptional regulation of pluripotent stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIN28A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cardiac Progenitor Differentiation | IRX4;SIRPA;ROR2;TBX20;SOX1;NOG;LIN28B;T;TBX5 |
| Developmental Biology | FRS2B;SPTB;CSNK2B;EFNA1A;CACNG2;MYL12B;LGI1;INSM1B;ARPC1A |
| Transcriptional regulation of pluripotent stem cells | NR6A1;FOXD3;SALL4;HIF3A;LIN28A;NR5A1;PRDM14;POU5F3;TDGF1 |
LIN28A has several biochemical functions, for example, DNA binding, RNA binding, mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIN28A itself. We selected most functions LIN28A had, and list some proteins which have the same functions with LIN28A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | NKX1.2LA;SIM2;LIG4;GPBP1L1;ARHGEF38;RXRAB;RARB;ZNF10;NKX2-3 |
| RNA binding | HNRNPH2;ILF3B;METTL14;AGO3B;RBFOX2;RANBP2;RDM1;NOP56;THOC1 |
| mRNA binding | ZFP36;G3BP1;C1QBP;TRA2B;SNRNP70;RBMX;NOVA1;RPS26L;PAIP2 |
| miRNA binding | MEF2C;TRIM71;EIF2C3;LIN28A;TARBP2;POU5F1;DICER1;SOX2;RBM4 |
| protein binding | MYRIP;TSPO;COL4A3;CFLAR;CTBP2;SKA3;OSBPL6;BLZF1;ATE1 |
| translation initiation factor binding | LARP1;EIF3BA;POLR2G;POLR2GL;TRIM32;EIF2B4;DDX3X;EIF2B5;LIN28A |
| zinc ion binding | RNF220A;CPA4;MLL5;ZNF385B;ZDHHC1;BIRC5;LIMK1A;MICALL1;RBM4 |
LIN28A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIN28A here. Most of them are supplied by our site. Hope this information will be useful for your research of LIN28A.
ZCCHC11; pre-let-7a; ZDHHC17
- Q&As
- Reviews
Q&As (6)
Ask a questionThe role of LIN28A in disease can be assessed through in-depth analysis of the patient's genomic data and combined with the results of studies in cell and animal models. This can help doctors better understand the patient's condition and develop more effective treatment plans.
Certain biomolecules can be used as molecular markers of LIN28A, such as mRNA or protein of LIN28A detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.
In clinical practice, treatment strategies related to LIN28A need to consider the patient's specific condition, genotype, and treatment goals. Doctors can develop a personalized treatment plan based on the patient's actual situation to improve the treatment effect and maximize the patient's quality of life. At the same time, long-term follow-up and studies are needed to assess the effectiveness and safety of treatment strategies.
The function of LIN28A can be studied through cell models and animal models. For example, the expression of LIN28A can be manipulated by gene knockout or overexpression techniques and then observed for its effects on cell biology and animal behavior.
Therapeutic strategies for LIN28A include inhibiting its expression, modulating its activity, or using gene therapy. For example, some small molecule inhibitors can inhibit the activity of LIN28A, thereby treating some LIN28A-related diseases.
The effect of LIN28A on disease can be predicted by comparing the expression level, sequence, and structure in different disease tissues and normal tissues. This could help scientists better understand the role of LIN28A in disease.
Customer Reviews (3)
Write a reviewLIN28A is green and environmentally friendly, and has little harm to the human body.
It is easy to adhere to the surface of the material, reducing the loss of reagents and reducing costs.
The preparation cost is low and cost-effective.
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