llgl1
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  • Official Full Name
  • lethal giant larvae homolog 1
  • Background
  • LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17. LLGL2 is a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells.
  • Synonyms
  • LLGL1 + LLGL2; DLG4; HGL; HUGL; HUGL 1; HUGL1; Human homolog to the D lgl gene protein; lethal giant larvae homolog 1; lethal giant larvae homolog 2; Lethal(2) giant larvae protein homolog 1; Lethal(2) giant larvae protein homolog 2; LGL2; LLGL
Cat.#:LLGL1-28095THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human LLGL1
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Cat.#:LLGL1-9140MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LLGL1 Protein
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Cat.#:LLGL1-3422RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LLGL1 Protein
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Cat.#:LLGL1-4410ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LLGL1
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Involved Pathway

LLGL1 involved in several pathways and played different roles in them. We selected most pathways LLGL1 participated on our site, such as Hippo signaling pathway, Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LLGL1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Hippo signaling pathway
TGFB3; TCF7L2; WNT5A; CTGF; FZD1; WNT6; DLG3; PARD3; GDF5; DVL3
Tight junction
CLDN5; OCLNA; ACTG1; PRKCI; CLDN19; MYL9A; F11R.1; TJP1; ACTB; CLDNG

Protein Function

LLGL1 has several biochemical functions, for example, GTPase activator activity, Rab GTPase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LLGL1 itself. We selected most functions LLGL1 had, and list some proteins which have the same functions with LLGL1. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase activator activity
Related Protein CHN2; CHML; ARHGAP4; ABR; TBC1D2; ARHGAP5; AXIN2; GIT2A; TBC1D9B; ASAP1A
Function Rab GTPase binding
Related Protein EHD1; EXPH5; GDI1; ERC1; KIF16B; AP1G1; PDE6D; CCDC64B; EVI5; PPIAL4A
Function protein binding
Related Protein IL5; PLLP; BMP2; UBE2N; SH2B2; KDM1A; DKK1B; TSTD2; CREB3; TNFRSF1B
Function protein kinase binding
Related Protein HSP90AB1; SOCS1; KIF11; TRAP1; DVL1; VDAC1; SHC1; CCNL1B; GOLGA2; CDK5RAP1
Function structural molecule activity
Related Protein INAA; MPZL1; RLN3B; EPB41L3A; KRT25; DESMB; CLDNK; KRT4; KRT26; KRT33A
Function NOT syntaxin binding
Related Protein C2CD4B; C2CD4A; LLGL2; LLGL1; TC2N

Interacting Protein

LLGL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LLGL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LLGL1.
PRKCI; PARD6B; SQSTM1; KBTBD7; PRKCZ; PARD6G; PARD6A; TIMM13

LLGL1 Related Articles

Wang, M; Meng, JY; et al. Xihuang Pill induces mesenchymal-epithelial transition and inhibits loss of apical-basal polarity in colorectal cancer cell through regulating ZEB1-SCRIB Loop. CHINESE JOURNAL OF INTEGRATIVE MEDICINE 20:751-757(2014).
Jagut, M; Mihaila-Bodart, L; et al. A Mosaic Genetic Screen for Genes Involved in the Early Steps of Drosophila Oogenesis. G3-GENES GENOMES GENETICS 3:409-425(2013).