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LLGL1

Official Full Name

lethal giant larvae homolog 1
Overview

LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17. LLGL2 is a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells.
Synonyms

LLGL1 + LLGL2; DLG4; HGL; HUGL; HUGL 1; HUGL1; Human homolog to the D lgl gene protein; lethal giant larvae homolog 1; lethal giant larvae homolog 2; Lethal(2) giant larvae protein homolog 1; Lethal(2) giant larvae protein homolog 2; LGL2; LLGL;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

HEK293
Mammalian Cell
Wheat Germ

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	LLGL1-28095TH	Recombinant Human LLGL1	Wheat Germ	N/A	100 amino acids	Inquiry
Mouse	LLGL1-9140M	Recombinant Mouse LLGL1 Protein	Mammalian Cell	His		Inquiry
Mouse	LLGL1-5106M	Recombinant Mouse LLGL1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	LLGL1-5106M-B	Recombinant Mouse LLGL1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	LLGL1-3422R	Recombinant Rat LLGL1 Protein	Mammalian Cell	His		Inquiry
Rat	LLGL1-3078R	Recombinant Rat LLGL1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	LLGL1-3078R-B	Recombinant Rat LLGL1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	LLGL1-4410Z	Recombinant Zebrafish LLGL1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
LLGL1 Related Articles

LLGL1 involved in several pathways and played different roles in them. We selected most pathways LLGL1 participated on our site, such as Hippo signaling pathway, Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LLGL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Hippo signaling pathway	FZD6;WNT1;CTNNA2;TEAD4;LLGL1;YAP1;SAV1;TEAD3;BMP5
Tight junction	PPP2R1A;CRB3;CLDNG;CLDNE;RHOAC;PPP2CB;EPB41;MYH1E;MAGI2

LLGL1 has several biochemical functions, for example, GTPase activator activity, Rab GTPase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LLGL1 itself. We selected most functions LLGL1 had, and list some proteins which have the same functions with LLGL1. You can find most of the proteins on our site.

Function	Related Protein
GTPase activator activity	TBC1D30;TBC1D2B;PGAM5;GARNL3;RASAL3;TBC1D24;CDC42EP1B;ACAP3B;CDC42EP5
Rab GTPase binding	ERC1;ANKFY1;SYTL3;DENND5A;UNC13D;TBC1D30;MICAL1;TBC1D20;EVI5L
protein binding	GGA1;SRSF1;PHYHIPL;MYLIP;NUAK1;IKBKE;WNT11;IFITM1;RAPGEF6
protein kinase binding	AP2A2;LIPE;RB1CC1;NIPAL1;GSK3B;KCNA5;HCLS1;PTPRC;HDAC7A
structural molecule activity	CYT1;SPRR2A;FGG;KRT75;CSTA;KRT35;SEMG2;TUBB5;CLDN23
NOT syntaxin binding	LLGL1;TC2N;C2CD4A;LLGL2;C2CD4B

LLGL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LLGL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LLGL1.

PRKCI; PARD6B; SQSTM1; KBTBD7; PRKCZ; PARD6G; PARD6A; TIMM13

Wang, M; Meng, JY; et al. Xihuang Pill induces mesenchymal-epithelial transition and inhibits loss of apical-basal polarity in colorectal cancer cell through regulating ZEB1-SCRIB Loop. CHINESE JOURNAL OF INTEGRATIVE MEDICINE 20:751-757(2014).

Jagut, M; Mihaila-Bodart, L; et al. A Mosaic Genetic Screen for Genes Involved in the Early Steps of Drosophila Oogenesis. G3-GENES GENOMES GENETICS 3:409-425(2013).