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LOXL3

  • Official Full Name

    lysyl oxidase-like 3

  • Overview

    This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the;biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first;step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus;end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function.;The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor;suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript;variants of this gene have been reported but their full-length nature has not been determined.
  • Synonyms

    LOXL3; lysyl oxidase-like 3; LOXL; lysyl oxidase homolog 3; lysyl oxidase-like protein 3; EC 1.4.3.13;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • CHO
  • E.coli
  • HEK293
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LOXL3-1979H Active Recombinant Human Lysyl Oxidase-Like 3, His-tagged CHO His
Human LOXL3-132H Recombinant Human LOXL3, GST-tagged Sf9 Insect Cell GST
Human LOXL3-4730H Recombinant Human LOXL3 Protein, GST-tagged Wheat Germ GST
Human LOXL3-5212H Recombinant Human LOXL3 Protein (Thr519-Asn726), His tagged E.coli His Thr519-Asn726
Human LOXL3-1419H Recombinant Human LOXL3 protein, His-GST-tagged E.coli His/GST 401-608aa
Human LOXL3-277H Recombinant Human LOXL3 Protein, His-tagged E.coli His Thr519~Asn726
Mouse LOXL3-9187M Recombinant Mouse LOXL3 Protein Mammalian Cell His
Mouse LOXL3-5133M Recombinant Mouse LOXL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Loxl3-278M Recombinant Mouse Loxl3 Protein, His-tagged E.coli His His509~Met712
Mouse LOXL3-5133M-B Recombinant Mouse LOXL3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

LOXL3 involved in several pathways and played different roles in them. We selected most pathways LOXL3 participated on our site, such as Assembly of collagen fibrils and other multimeric structures, Collagen formation, Crosslinking of collagen fibrils, which may be useful for your reference. Also, other proteins which involved in the same pathway with LOXL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Assembly of collagen fibrils and other multimeric structuresCD151;LOX;COL8A2;COL5A1;CTSL2;COL1A1;BMP1A;MMP13;COL4A6
Collagen formationCOL28A1;CTSB;COL28A1A;COL17A1;P3H2;COL6A2;LOXL2;PRP;LEPREL1
Crosslinking of collagen fibrilsABHD1;PCOLCE;LOXL1;TLL2;LOXL2;BMP1A;LOX;BMP1;BMP1B
Elastic fibre formationEFEMP1;MFAP1;FBN1;ITGB3A;LOXL2;LOX;MFAP5;LTBP2;BMP10
Extracellular matrix organizationBSG;LTBP3;COL16A1;COL4A5;FURINB;MATN3B;COL9A1B;COL4A4;ADAM9

LOXL3 has several biochemical functions, for example, copper ion binding, protein binding, protein-lysine 6-oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LOXL3 itself. We selected most functions LOXL3 had, and list some proteins which have the same functions with LOXL3. You can find most of the proteins on our site.

Function Related Protein
copper ion bindingS100A5;CP;TYRP1B;ABP1;PRND;SOD3A;S100V2;ATOX1;ATP7B
protein bindingDBNL;SLX4IP;ADRA2C;HNRNPK;SHC4;TNFRSF6B;CORO1B;TPT1;HACL1
protein-lysine 6-oxidase activityLOXL3;LOXL2A;POLR1B;LOX;LOXL2;LOXL4;ABHD1;LOXL2B
scavenger receptor activityPRG4B;VTN;CD6;TMPRSS4;VTNB;CD163;TINAG;SRCRB4D;TMPRSS3

LOXL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LOXL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of LOXL3.

GATAD2B; APMAP

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