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LPAR2

Official Full Name

lysophosphatidic acid receptor 2
Overview

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined.
Synonyms

LPAR2; lysophosphatidic acid receptor 2; EDG4, endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 4; EDG 4; LPA2; LPA receptor 2; LPA receptor EDG4; G protein-coupled receptor; lysophosphatidic acid receptor EDG4; lysophosphat;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Homo sapiens (Human)
Human
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Mus musculus (Mouse)
Rhesus Macaque

Source

E.coli expression system
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	LPAR2-4021H	Recombinant Human LPAR2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	LPAR2-4674HCL	Recombinant Human LPAR2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	LPAR2-4726H	Recombinant Human LPAR2 Protein	Wheat Germ	N/A		Inquiry
Human	LPAR2-4692HF	Recombinant Full Length Human LPAR2 Protein, GST-tagged	In Vitro Cell Free System	GST	351 amino acids	Inquiry
Human	LPAR2-5968HF	Recombinant Full Length Human LPAR2 Protein	In Vitro Cell Free System		400 amino acids	Inquiry
Homo sapiens (Human)	RFL30799HF	Recombinant Full Length Human Lysophosphatidic Acid Receptor 2(Lpar2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-351)	Inquiry
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)	RFL5762MF	Recombinant Full Length Macaca Fascicularis Lysophosphatidic Acid Receptor 2(Lpar2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-351)	Inquiry
Mus musculus (Mouse)	RFL1395MF	Recombinant Full Length Mouse Lysophosphatidic Acid Receptor 2(Lpar2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-348)	Inquiry
Rhesus Macaque	LPAR2-2540R	Recombinant Rhesus monkey LPAR2 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	LPAR2-2360R	Recombinant Rhesus Macaque LPAR2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	LPAR2-2360R-B	Recombinant Rhesus Macaque LPAR2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	LPAR2-3830C	Recombinant Chicken LPAR2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
LPAR2 Related Articles

LPAR2 involved in several pathways and played different roles in them. We selected most pathways LPAR2 participated on our site, such as Rap signaling pathway, Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPAR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Rap signaling pathway	PRKCZ;MAPK13;PFN2;TEK;PRKCA;LPAR2;VEGFC;INSR;RAF1
Phospholipase D signaling pathway	RHOA;CYTH4;AGTR1A;KRAS;GNA12;PIK3CG;IL-8;PIK3CB;MS4A2
Neuroactive ligand-receptor interaction	GABRG2;AGTR2;APLNR;NPFFR1;GRIN2C;HTR1F;P2RX1;NR3C1;PTGDR
PIK-Akt signaling pathway	YWHAZ;CD19;PPP2R2D;GNG13;INS2;LPAR5;IL3RA;ITGB7;TRP53
Pathways in cancer	TRAF1;Flt3l;GNAI3;BAX;RALBP1;FGF17;SPI1;ROCK2;FGF12

LPAR2 has several biochemical functions, for example, G-protein coupled receptor activity, PDZ domain binding, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LPAR2 itself. We selected most functions LPAR2 had, and list some proteins which have the same functions with LPAR2. You can find most of the proteins on our site.

Function	Related Protein
G-protein coupled receptor activity	GRM2;GNRHR2;OLFR495;HTR1AA;FFAR3;GPR149;CALCRLA;VMN1R54;CHRM5B
PDZ domain binding	PTENA;GRASP;Fzd4;SRR;ARHGAP29;FZD3;CFTR;GRIK5;BAIAP2
lipid binding	BPIFB2;LTC4S;SH3GL2;EPN2;MELK;Fert2;BAIAP2L2B;PACSIN1B;APOA4A
lysophosphatidic acid receptor activity	LPAR2A;LPAR2B;LPAR2;LPAR6A;LPAR1;LPAR3
protein binding	ALKBH6;FCRL2;SNTA1;WASL;TMEM203;ITGB3BP;SIP1;CACFD1;LSM11

LPAR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPAR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LPAR2.

CFTR; SLC9A3R2; ATXN1; BCL6

Kuriyama, S; Theveneau, E; et al. In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity. JOURNAL OF CELL BIOLOGY 206:113-127(2014).

Purvanov, V; Holst, M; et al. G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion. ELIFE 3:-(2014).