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LSM4

  • Official Full Name

    LSM4 homolog, U6 small nuclear RNA associated

  • Overview

    This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind;specifically to the 3-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6;snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this;gene.
  • Synonyms

    LSM4; LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); U6 snRNA-associated Sm-like protein LSm4; YER112W; glycine-rich protein; GRP;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • N/A
  • N
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LSM4-188H Recombinant Human LSM4 Protein, His-tagged E.coli His
Human LSM4-3007H Recombinant Human LSM4 Homolog, U6 Small Nuclear RNA Associated (S. Cerevisiae), T7-tagged E.coli T7
Human LSM4-3398H Recombinant Human LSM4, His-tagged E.coli His
Human LSM4-9173HCL Recombinant Human LSM4 293 Cell Lysate HEK293 N/A
Human LSM4-3185H Recombinant Human LSM4 protein, His-SUMO-tagged E.coli His-SUMO 1-139aa
Human LSM4-4170H Recombinant Human LSM4 Protein (Met1-Gln139), N-His tagged E.coli N-His Met1-Gln139
Human LSM4-1867H Recombinant Human LSM4 protein, GST-tagged E.coli GST 1-139 aa
Human LSM4-4608H Recombinant Human LSM4 Protein, GST-tagged Wheat Germ GST
Human LSM4-5997HF Recombinant Full Length Human LSM4 Protein, GST-tagged In Vitro Cell Free System GST 139 amino acids
Rhesus Macaque LSM4-2584R Recombinant Rhesus monkey LSM4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque LSM4-2404R Recombinant Rhesus Macaque LSM4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque LSM4-2404R-B Recombinant Rhesus Macaque LSM4 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish LSM4-10962Z Recombinant Zebrafish LSM4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LSM4 Related Articles

LSM4 involved in several pathways and played different roles in them. We selected most pathways LSM4 participated on our site, such as RNA degradation, Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with LSM4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
RNA degradationENO1B;groL;HSPA9;EXOSC4;PFKL;CNOT10;BTG2;TOB1A;TOB2
SpliceosomeSART1;RBM22;DHX8;PRPF38A;PRPF6;THOC1;TCERG1;SF3B4;BUD31

LSM4 has several biochemical functions, for example, U6 snRNA binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LSM4 itself. We selected most functions LSM4 had, and list some proteins which have the same functions with LSM4. You can find most of the proteins on our site.

Function Related Protein
U6 snRNA bindingLSM4;SART3;LSM7;DDX39B;LSM2;RBM22;LSM8;EIF5A;PRPF8
poly(A) RNA bindingKHDRBS3;NCL;ROCK2;RPL36;ALDH6A1;HSP90AA1;CEBPZ;GOT2;HIST1H4C
protein bindingHDAC9;NSFL1C;PPP1R12B;MINK1;NR1H2;TCOF1;MED9;AAK1;SMC1A

LSM4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LSM4 here. Most of them are supplied by our site. Hope this information will be useful for your research of LSM4.

CALCOCO2; LSM7; PSTPIP1; IKZF1; ZBTB10; L3MBTL3

Schneider, MD; Najand, N; et al. Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development. JOURNAL OF CELL BIOLOGY 174:349-358(2006).
Eystathioy, T; Peebles, CL; et al. Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera. ARTHRITIS AND RHEUMATISM 46:726-734(2002).
Eystathioy, T; Peebles, CL; et al. Human anti-Sm antibodies recognize LSm4 and LSm heptameric complex.. ARTHRITIS AND RHEUMATISM 43:S327-S327(2000).
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