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LYN

  • Official Full Name

    v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

  • Overview

    Lyn, one of the Src family members, is predominantly expressed in hematopoietic cells. Two tyrosine residues have been reported to play a crucial role in the regulation of protein tyrosine kinases of the Src family. Autophosphorylation of Tyr396 (equivale
  • Synonyms

    LYN; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; tyrosine-protein kinase Lyn; JTK8; lck/Yes-related novel protein tyrosine kinase; p53Lyn; p56Lyn; FLJ26625;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect cell
  • Insect Cell
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • DDK
  • Flag
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • Myc
  • Myc|DDK
  • N/A
  • N
  • FLAG
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LYN-252H Active Recombinant Human LYN Protein, GST-tagged Insect Cell GST
Human LYN-95HFL Active Recombinant Full Length Human LYN Protein, N-His-tagged Sf21 His Full Length
Human LYN-27984TH Recombinant Human LYN N/A
Human LYN-28760TH Recombinant Human LYN E.coli N/A
Human LYN-1254H Recombinant Human V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, His-tagged Insect Cell N/A
Human LYN-7218H Recombinant Human LYN, His-tagged E.coli His 1-512aa
Human LYN-643H Recombinant Human LYN, GST-tagged E.coli GST
Human LYN-1127H Recombinant Human V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, GST-tagged Sf9 Insect Cell GST
Human LYN-61H Recombinant Human LYN protein, Flag-tagged, Biotinylated Insect Cell Flag
Human LYN-656HCL Recombinant Human LYN cell lysate Insect Cell N/A
Human LYN-4556H Recombinant Human LYN Protein, GST-tagged Wheat Germ GST
Human LYN-4557H Active Recombinant Human LYN Protein, GST/His-tagged Insect Cell GST/His
Human LYNA-760H Active Recombinant Human LYNA Protein, His/GST-tagged Insect cell His&GST
Human LYN-9787HF Active Recombinant Full Length Human LYN Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-512(end)
Human LYN-1343H Recombinant Human LYN Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human LYN-6237HF Recombinant Full Length Human LYN Protein, GST-tagged In Vitro Cell Free System GST 512 amino acids
Human LYN-3071HF Active Recombinant Full Length Human LYN Protein, GST-tagged Insect (sf21) GST 1-491(end)
Human LYN-4696HF Active Recombinant Full Length Human LYN Protein, GST-tagged Insect (sf21) GST 1-512(end)
Human LYN-514H Recombinant Human LYN Protein, His-tagged E.coli His Val263~Pro491
Human LYN-0766H Recombinant Human LYN Protein (K233-P512), Tag Free Insect Cell No tag K233-P512
Human LYN-2705H Recombinant Human LYN Protein (Met263-Asp491), His tagged E.coli His Met263-Asp491
Human LYN-0767H Recombinant Human LYN Protein (K233-P512), His tagged Insect Cell His K233-P512
Human LYN-4990H Recombinant Human LYN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human LYN-12H Recombinant Human LYN Protein (Full Length), N-FLAG tagged Insect Cell N-FLAG Full Length
Mouse LYN-96MFL Active Recombinant Full Length Mouse LYN Protein, N-His-tagged Sf21 His Full Length
Mouse LYN-9386M Recombinant Mouse LYN Protein Mammalian Cell His
Mouse LYN-5263M-B Recombinant Mouse LYN Protein Pre-coupled Magnetic Beads HEK293
Mouse Lyn-3877M Recombinant Mouse Lyn Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Lyn-3194M Recombinant Mouse Lyn protein, His&Myc-tagged E.coli His&Myc 2-512aa
Mouse LYN-5263M Recombinant Mouse LYN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat LYN-3514R Recombinant Rat LYN Protein Mammalian Cell His
Rat LYN-3170R Recombinant Rat LYN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat LYN-3170R-B Recombinant Rat LYN Protein Pre-coupled Magnetic Beads HEK293
Zebrafish LYN-1267Z Recombinant Zebrafish LYN Mammalian Cell His
Chicken LYN-1532C Recombinant Chicken LYN Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LYN Related Articles
  • LYN Related Research Area

LYN involved in several pathways and played different roles in them. We selected most pathways LYN participated on our site, such as Chemokine signaling pathway, NF-kappa B signaling pathway, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with LYN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chemokine signaling pathwayPRKCZ;CDC42;CXCR3;GSK3A;XCL2;CCL22;GM1987;PRKACG;PF4V1
NF-kappa B signaling pathwayNFKB1;LTBR;TRAF1;TNFRSF13C;BIRC3;TICAM2;MAP3K7;CCL4;CCL21B
Platelet activationMAPK13;MYL12B;BTK;VAMP8;F2R;GP9;ITPR3;ROCK2;MAPK11
B cell receptor signaling pathwayGSK3AB;LCP2A;ARPC5;AKT2;PIK3CB;NFKBIE;PIK3R1;AKT1;PILRB
Fc epsilon RI signaling pathwaySOS1;PRKCA;MAPK1;GM-CSF;PLA2G4F;IL5;MAPK9;PIK3CG;MAP2K7
Fc gamma R-mediated phagocytosisASAP3;ASAP2;MAPK3;GSN;AMPH;FCGR2A;SYK;PRKCA;RAC1
Long-term depressionCRHR1;PPP2CA;GNAI1;PPP2R1B;MAPK1;GNA11;NOS1;GNAZ;GRIA3
Epithelial cell signaling in Helicobacter pylori infectionATP6V0C;ATP6V1C2;IKBKB;ATP6V0B;MAPK10;MAP2K4;MAPK9;CXCR1;ATP6V1E2
Epstein-Barr virus infectionIKBKB;TAB1;HLA-B;IRAK1;MAP2K7;MAP2K3;TBPL2;GTF2E2;EIF2AK4
Viral carcinogenesisLYN;PMAIP1;HIST2H2BE;MAPK3;HIST1H4N;HIST1H2BD;HIST1H2BJ;TRAF5;PIK3R5

LYN has several biochemical functions, for example, ATP binding, SH3 domain binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LYN itself. We selected most functions LYN had, and list some proteins which have the same functions with LYN. You can find most of the proteins on our site.

Function Related Protein
ATP bindingUBE2KB;PAK2A;VRK2;GUCY2F;CHD4;PMVK;KIF5AA;RET;MYO18A
SH3 domain bindingERRFI1;CD2AP;VASPA;FMN1;ARHGAP6;CTTNBP2;ABL1;HCLS1;CYBA
enzyme bindingRARA;UGT1A6B;PUS7;DAXX;TNKS2;UGT1A9;SELS;N4BP2L2;PLCB1
gamma-tubulin bindingNDN;LYN;TUBGCP2;RAD51L3;NME2;CEP57;CEP57L1;DIXDC1;BRCA2
glycosphingolipid bindingIl2;LYN;SELP;LAMC1;LAMB1;SELL;Cel;LAMA1
integrin bindingFN1A;THY1;CTGFB;EDIL3;ITGA6;PXN;WISP1A;WISP3;FBLN1
ion channel bindingKCNJ11;S100A10;KCNQ3;PACS1A;LRRK2;CALM;YWHAQ;CAV1;KCNE4
non-membrane spanning protein tyrosine kinase activityTNK2;PTK2BB;PTK2B;ITK;TYK2;FYNA;PRKCD;EIF2AK2;JAK1
phosphoprotein bindingMID1;PLAT;SRC;SNCA;DPYS;DPYSL3;IGF2R;MTOR;MID2
platelet-derived growth factor receptor bindingPDGFC;LYN;PTEN;PDGFAA;ITGB3;IL1R1;FIGF;PDGFD;PDGFRB
protein bindingMAB21L1;CCT5;ACTR1B;SH2D2A;GBF1;OOEP;HIPK2;ZNF131;CTDNEP1
protein tyrosine kinase activityNTRK2B;EPHA4A;IGF1R;SRMS;WEE1;KDR;PDGFRB;FYN;EPHA7
receptor bindingIDUA;SLC9A3R2;TNFSF10;ACOT2;CCL2;BMP3;TNFSF18;NPPA;DAO
receptor signaling protein tyrosine kinase activityERBB2;ERBB4A;EGFRA;INSR;TYRO3;KITA;KITB;EGFR;KIT
ubiquitin protein ligase bindingCUL1;CDKN1A;UBE2B;BCL10;SLC22A18;TMEM189;UBXN1;TPI1;MC1R

LYN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LYN here. Most of them are supplied by our site. Hope this information will be useful for your research of LYN.

EGFR; polg_hcvh; polg_hcvco; KHDRBS1; polg_hcvj4; PTK2; tip_shv2c

Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).
Xiao, ZG; Sperl, B; et al. Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status. ONCOTARGET 5:12877-12890(2014).
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