Lipc
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Official Full Name
lipase, hepatic
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Overview
LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. -
Synonyms
LIPC; lipase, hepatic; HL; HTGL; LIPH; HDLCQ12;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bacillus subtilis
- Human
- Mouse
- Pig
- Rat
- E. coli or Yeast
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- His|GST
- SUMO
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
Lipc involved in several pathways and played different roles in them. We selected most pathways Lipc participated on our site, such as Glycerolipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with Lipc were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Glycerolipid metabolism | PNPLA3;AGPAT3;PNLIP;AKR1B1;ALDH1B1;DGAT1;AKR1B8;DGAT2;GLA |
Metabolic pathways | DCXR;Atp5g2;PAFAH1B2;SC4MOL;CYP27A1;TUSC3;GUSB;COX4I2;GLCE |
Lipc has several biochemical functions, for example, apolipoprotein binding, heparin binding, low-density lipoprotein particle binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Lipc itself. We selected most functions Lipc had, and list some proteins which have the same functions with Lipc. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
apolipoprotein binding | PCSK9;LPL;PLG;LIPC;ABCA1;LRP1;SCARB1;LRP4;CANX |
heparin binding | ZNF207;LPL;WISP1A;CCL8;CCDC80;LXN;FN1;LIPC;FMOD |
low-density lipoprotein particle binding | COLEC12;SORL1;SCARF1;LIPC;THBS1;ANKRA2;SCARB1;LDLR;CRP |
phospholipase activity | PNLIPRP2;CEL.1;LIPC;DAGLB;PLA2G4AA;PLA2G10;LIPK;ABHD2B;LIPI |
triglyceride lipase activity | Cel;AADAC;PNPLA2;LIPCA;CEL.1;PNLIPRP3;LIPC;CES1D;LIPF |
Lipc has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Lipc here. Most of them are supplied by our site. Hope this information will be useful for your research of Lipc.
ADHFE1
- Q&As
- Reviews
Q&As (5)
Ask a questionGenetic variations in the LIPC gene can influence enzyme activity, impacting lipid metabolism. Certain variants are associated with an increased risk of metabolic disorders such as dyslipidemia and insulin resistance.
LIPC contributes to lipid homeostasis by breaking down lipids, regulating their levels in the bloodstream. Dysregulation of LIPC activity is associated with imbalances in lipid profiles and an increased risk of cardiovascular diseases.
The expression of the LIPC gene is influenced by various factors, including dietary fat intake, hormonal signals, and genetic predisposition. Transcriptional regulators and epigenetic modifications also play a role.
LIPC interacts with various proteins in lipid metabolism pathways. Disruptions in these interactions can lead to impaired lipid processing, contributing to metabolic disorders and cardiovascular diseases.
Techniques such as RT-PCR, Western blotting, and enzyme assays are commonly used to study LIPC expression and activity. Additionally, advanced methods like mass spectrometry provide insights into post-translational modifications.
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