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MOGS

Official Full Name

mannosyl-oligosaccharide glucosidase
Overview

This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene.
Synonyms

MOGS; mannosyl-oligosaccharide glucosidase; GCS1; glucosidase I; processing A glucosidase I; processing A-glucosidase I; CDG2B;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
His|T7

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MOGS-7916H	Recombinant Human MOGS protein, His & T7-tagged	E.coli	His/T7	Arg60~Leu352 (Accession # Q13724)	Inquiry
Mouse	Mogs-7917M	Recombinant Mouse Mogs protein, His & T7-tagged	E.coli	His/T7	Leu512~Tyr834 (Accession # Q80UM7)	Inquiry
Mouse	MOGS-9954M	Recombinant Mouse MOGS Protein	Mammalian Cell	His		Inquiry
Mouse	MOGS-5627M	Recombinant Mouse MOGS Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	MOGS-5627M-B	Recombinant Mouse MOGS Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	MOGS-5046Z	Recombinant Zebrafish MOGS	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MOGS Related Articles

MOGS involved in several pathways and played different roles in them. We selected most pathways MOGS participated on our site, such as N-Glycan biosynthesis, Metabolic pathways, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with MOGS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
N-Glycan biosynthesis	MAN1A2;MGAT4B;DOLK;RPN1;B4GALT2;ALG9;STT3A;ALG10;MGAT1
Metabolic pathways	MGAT3;TRIT1;CYP2P7;AKR1A1A;PLCB1;GALNTL1;PTDSS2;ASPA;STT3A
Protein processing in endoplasmic reticulum	WFS1;EIF2AK4;MAN1A;SEC24B;MAN1C1;HSP90AA1.2;BAK1;HSPA2;CUL1B

MOGS has several biochemical functions, for example, catalytic activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds. Some of the functions are cooperated with other proteins, some of the functions could acted by MOGS itself. We selected most functions MOGS had, and list some proteins which have the same functions with MOGS. You can find most of the proteins on our site.

Function	Related Protein
catalytic activity	ALDOCA;SYN2A;ALDOAA;PPM1LB;ACLYA;MOSC2;CKBB;SLC3A2;BLM
hydrolase activity	CAPN3A;NDST2;CASPB;GPN3;FAAH2;MCM6L;ABHD14B;PTPN11A;CDC14AB
hydrolase activity, acting on glycosyl bonds	UNGA;MOGS;LYZ1;NEIL1;MUTYH;Art2b;HPSE2;LYZ2;SPACA5
mannosyl-oligosaccharide glucosidase activity

MOGS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MOGS here. Most of them are supplied by our site. Hope this information will be useful for your research of MOGS.

Hmga2; Ywhae; Ywhab; Hsd3b7

Kozela, E; Juknat, A; et al. Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells. JOURNAL OF NEUROINFLAMMATION 12:-(2015).

Probstel, AK; Rudolf, G; et al. Anti-MOG antibodies are present in a subgroup of patients with a neuromyelitis optica phenotype. JOURNAL OF NEUROINFLAMMATION 12:-(2015).