MYL12A
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Official Full Name
myosin, light chain 12A, regulatory, non-sarcomeric
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Overview
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain,;such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments;(Iwasaki et al., 2001 (PubMed 11942626)). -
Synonyms
MYL12A; myosin, light chain 12A, regulatory, non-sarcomeric; myosin, light polypeptide, regulatory, non sarcomeric (20kD); myosin regulatory light chain 12A; MLCB; MRCL3; MRLC3; MYL2B; myosin regulatory light chain 3; nonsarcomeric; RLC; ML12A_HUMAN; MLC 2B; MLC-2B; Myosin regulatory light chain 2; Myosin regulatory light chain 2, nonsarcomeric; Myosin regulatory light chain MRCL3; Myosin regulatory light chain MRLC3; Myosin RLC; OTTHUMP00000162243; myosin, light polypeptide, regula;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
MYL12A involved in several pathways and played different roles in them. We selected most pathways MYL12A participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYL12A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | EPHA10;ARPC5;RAC1;PHB;EVL;PAK2;ACTR2B;PEBP1;Ntng2 |
| Developmental Biology | ARPC1A;CDK5R1B;DPYSL5A;MED16;AP2A2;MYL12A;TDGF1;RASGRP4;RANBP9 |
| EPH-Ephrin signaling | MYL12A;EFNA4;ARPC3;CLTC;EFNB2A;KDR;AP2M1;AP2S1;SHB |
| Ephrin signaling | EFNB2;SDCBP;EFNB3;EFNB1;EPHB4A;EPHB3A;MYL12A;EPHB4B;EFNB3B |
| Focal adhesion | TNK1;MYLPFA;PTK2AA;PDGFAA;GSK3B;VAV2;ACTG1;FN1A;ACTB2 |
| Leukocyte transendothelial migration | PIK3R1;CLDN18;Itgam&Itgb2;PIK3CB;MYL10;GNAI1;CYBA;VAV3;PRKCG |
| Muscle contraction | TNNT3A;MYL9;TMOD2;TNNI1;TNNI2A.1;TNNI2;TNNT1;TMOD1;MYBPC2 |
| Platelet activation | MYLK4;PRKACG;PIK3CB;VAMP8;BTK;PIK3CD;ITPR3;LYN;GUCY1A3 |
MYL12A has several biochemical functions, for example, calcium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYL12A itself. We selected most functions MYL12A had, and list some proteins which have the same functions with MYL12A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | CRELD2;ATP2A1;CALB1;CAPN2B;GUCA1A;NCAN;S100P;GAS6;PCDH2G1 |
| protein binding | H3F3B;APBB3;SNX15;ILVBL;USP42;CCNK;IFT20;RALB;RNF183 |
MYL12A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYL12A here. Most of them are supplied by our site. Hope this information will be useful for your research of MYL12A.
IKBKE; GRB2; CIT; Cdc42bpa; PAK1; MYLK; CDC42BPA; Rock2; Cdc42bpb; CHUK; EIF1B; TNFRSF1A; MCC; VHL; ACTB; MAP3K3; TNIK
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