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NF1

  • Official Full Name

    neurofibromin 1

  • Synonyms

    NF1; neurofibromin 1; neurofibromin; neurofibromatosis; von Recklinghausen disease; Watson disease; neurofibromatosis-related protein NF-1; WSS; NFNS; VRNF; FLJ21220; DKFZp686J1293;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • E. coli
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NF1-334H Recombinant Human NF1 Protein, His-tagged E. coli His
Human NF1-335H Recombinant Human NF1, GST-tagged Wheat Germ GST
Human NF1-32H Active Recombinant Human NF1 Protein (1197-1528), N-His tagged E.coli N-His 1197-1528
Rat NF1-3967R Recombinant Rat NF1 Protein Mammalian Cell His
Rat NF1-3625R-B Recombinant Rat NF1 Protein Pre-coupled Magnetic Beads HEK293
Rat NF1-3625R Recombinant Rat NF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NF1 Related Articles

NF1 involved in several pathways and played different roles in them. We selected most pathways NF1 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayNR4A1;PRKACBA;LAMTOR3;RASGRF2B;RPS6KA3B;PLA2G4AA;MAPK3;CACNB2A;ELK1
Ras signaling pathwayPAK3;FGFR4;RHOA;ETS2;FASLG;FGF2;MLLT4;FOXO4;PLCG1

NF1 has several biochemical functions, for example, GTPase activator activity, phosphatidylcholine binding, phosphatidylethanolamine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NF1 itself. We selected most functions NF1 had, and list some proteins which have the same functions with NF1. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activityARHGAP32;RP2;CDC42EP3;AGFG1A;TBC1D20;ARHGAP28;TBC1D4;RGS7;ARHGAP31
phosphatidylcholine bindingGPR119;ESYT2;PCTP;CETP;NF1;CHMP3;ALDOB;APOA4;APOA1A
phosphatidylethanolamine bindingCD300A;ANXA11;MFGE8;PEBP1;LC3;ESYT2;PEMT;NF1
protein bindingPKIA;SPON2;RAF1;SLC7A11;ZC3H15;PDE9A;RBBP6;IGBP1;STAM

NF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NF1.

APP; PML; SUMO1; DYNC1H1; Sdc1; Sdc3; SDC2; Sdc2; Sdc4; pi3p

Reuss, DE; Habel, A; et al. Neurofibromin specific antibody differentiates malignant peripheral nerve sheath tumors (MPNST) from other spindle cell neoplasms. ACTA NEUROPATHOLOGICA 127:565-572(2014).
Ypsilantis, P; Lambropoulou, M; et al. A case of diffuse bilateral scrotal neurofibroma in a rabbit. JOURNAL OF SMALL ANIMAL PRACTICE 54:491-494(2013).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the primary function of the NF1 gene and its encoded protein? 11/05/2022

The NF1 gene encodes neurofibromin, a protein primarily known for its role as a tumor suppressor. It regulates cell growth and differentiation.

How do mutations in the NF1 gene contribute to tumorigenesis? 11/21/2021

Mutations in the NF1 gene can lead to a loss of neurofibromin function, resulting in uncontrolled RAS activation and increased cell proliferation, contributing to tumorigenesis.

How is the NF1 protein involved in the RAS/MAPK signaling pathway? 02/19/2021

Neurofibromin, the product of the NF1 gene, acts as a GTPase-activating protein (GAP) for RAS, accelerating the conversion of active RAS-GTP to its inactive form RAS-GDP, thereby negatively regulating the RAS/MAPK pathway.

Are there any known interactions between NF1 and other tumor suppressor genes or oncogenes? 06/16/2020

NF1 interacts with several proteins in cellular pathways, including c-Raf, mTOR, and adenylate cyclase. Its dysregulation can influence the activity of these proteins and associated pathways.

How does NF1 influence cell growth and differentiation? 11/26/2019

By regulating the RAS/MAPK pathway, NF1 plays a crucial role in controlling cell growth, differentiation, and apoptosis.

What are the current therapeutic strategies targeting NF1-related disorders? 02/17/2019

Current therapeutic strategies for NF1-related disorders include surgical removal of tumors, targeted therapies like MEK inhibitors for plexiform neurofibromas, and regular monitoring for associated complications.

What are the clinical manifestations of Neurofibromatosis Type 1, the disorder associated with NF1 mutations? 02/13/2019

Neurofibromatosis Type 1 is characterized by multiple café-au-lait spots, skinfold freckling, neurofibromas, optic pathway gliomas, and certain bone abnormalities, among other manifestations.

Customer Reviews (3)

Write a review
Reviews
07/08/2021

    Clear instructions, easy protocol.

    03/15/2021

      Packaging was secure, intact.

      06/27/2020

        Product arrived in good condition.

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