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PAFAH2

Official Full Name

platelet-activating factor acetylhydrolase 2, 40kDa
Overview

This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme.
Synonyms

PAFAH2; platelet-activating factor acetylhydrolase 2, 40kDa; platelet activating factor acetylhydrolase 2 (40kD); platelet-activating factor acetylhydrolase 2, cytoplasmic; HSD PLA2; EC 3.1.1.47; HSDPLA2; Platelet activating factor acetylhydrolase 2; Serine dependent phospholipase A2; SD-PLA2; serine-dependent phospholipase A2; HSD-PLA2;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E. coli
E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
His|T7
MYC
DDK
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PAFAH2-2119H	Recombinant Human PAFAH2 protein, His & T7-tagged	E.coli	His/T7	Met1~Leu392 (Accession # Q99487)	Inquiry
Human	PAFAH2-3466HCL	Recombinant Human PAFAH2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	PAFAH2-19H	Recombinant Human PAFAH2 Protein, His-tagged	E.coli	His	2-392	Inquiry
Human	PAFAH2-039H	Recombinant Human PAFAH2 Protein, His-tagged	E. coli	His	2-392	Inquiry
Human	PAFAH2-4791H	Recombinant Human PAFAH2 Protein (Met1-Leu392), N-His tagged	E.coli	N-His	Met1-Leu392	Inquiry
Mouse	Pafah2-021M	Recombinant Mouse Pafah2 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Rat	PAFAH2-4256R	Recombinant Rat PAFAH2 Protein	Mammalian Cell	His		Inquiry
Rat	PAFAH2-3918R	Recombinant Rat PAFAH2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	PAFAH2-3918R-B	Recombinant Rat PAFAH2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
PAFAH2 Related Articles

PAFAH2 involved in several pathways and played different roles in them. We selected most pathways PAFAH2 participated on our site, such as Ether lipid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAFAH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ether lipid metabolism	PLD2;PLA2G2A;PLA2G2F;PPAP2D;PPAP2B;PLA2G16;PLD1;PPAP2CB;PLA2G5
Metabolic pathways	CYP19A1A;WBSCR17;NT5C1B;GUK1A;LIPCA;RPN1;TKT;aLA;ACAT2

PAFAH2 has several biochemical functions, for example, 1-alkyl-2-acetylglycerophosphocholine esterase activity, phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAFAH2 itself. We selected most functions PAFAH2 had, and list some proteins which have the same functions with PAFAH2. You can find most of the proteins on our site.

Function	Related Protein
1-alkyl-2-acetylglycerophosphocholine esterase activity	PAFAH1B3;PAFAH2;PAFAH1B2;PLA2G7;ASPG
phospholipid binding	DAPP1;WDFY4;TEC;SEC14L2;NBEA;OSBPL1A;APOC3;APOH;GRK5

PAFAH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAFAH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAFAH2.

Yan, JX; Hitomi, T; et al. Genetic Study of Intracranial Aneurysms. STROKE 46:620-+(2015).

Latchoumycandane, C; Marathe, GK; et al. Oxidatively Truncated Phospholipids Are Required Agents of Tumor Necrosis Factor alpha (TNF alpha)-induced Apoptosis. JOURNAL OF BIOLOGICAL CHEMISTRY 287:17693-17705(2012).