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PAPOLA

Official Full Name

poly(A) polymerase alpha
Overview

The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms

PAPOLA; poly(A) polymerase alpha; PAP; PAP-alpha; polynucleotide adenylyltransferase alpha; MGC5378;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rhesus Macaque
Zebrafish

Source

HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	PAPOLA-759H	Recombinant Human PAPOLA	Mammalian Cell	His	Inquiry
Human	PAPOLA-3791H	Recombinant Human PAPOLA Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Human	PAPOLA-3791H-B	Recombinant Human PAPOLA Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	PAPOLA-3298R	Recombinant Rhesus monkey PAPOLA Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	PAPOLA-3116R	Recombinant Rhesus Macaque PAPOLA Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	PAPOLA-3116R-B	Recombinant Rhesus Macaque PAPOLA Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	PAPOLA-11772Z	Recombinant Zebrafish PAPOLA	Mammalian Cell	His	Inquiry
Chicken	PAPOLA-4181C	Recombinant Chicken PAPOLA	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
PAPOLA Related Articles

PAPOLA involved in several pathways and played different roles in them. We selected most pathways PAPOLA participated on our site, such as Cleavage of Growing Transcript in the Termination Region, Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAPOLA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cleavage of Growing Transcript in the Termination Region	U2AF2;ZNF473;CSTF1;LSM11;LSM10;SLBP;NUDT21;CLP1;CSTF3
Gene Expression	MTA2;ZNF256;POP7;ZNF776;ANP32A;NRBP1;BRF1B;ELAC2;ZNF643
Processing of Capped Intron-Containing Pre-mRNA	HNRNPD;HNRNPR;SNRNP35;CD2BP2;RNPC3;PDCD7;SNRNP48;SFRS3A;METTL3
Processing of Capped Intronless Pre-mRNA	LSM10;CSTF2;PAPOLA;SLBP;CLP1;CSTF3;NUDT21;CSTF1;LSM11
Processing of Intronless Pre-mRNAs	CSTF1;CSTF3;CLP1;CSTF2;PAPOLA;NUDT21
RNA Polymerase II Transcription	SLBP;LSM10;ZFP473;CCNT2A;CCNT2B;THOC4;GM3258;CSTF1;SUPT16H
RNA Polymerase II Transcription Termination	SLBP;CSTF1;RNPS1;LSM10;NUDT21;LSM11;THOC4;CSTF2;ZNF473
TNF-alpha/NF-kB Signaling Pathway	PDCD2;CAPN3;KIAA1967;DPF2;CSNK2A1P;PAPOLA;TRPC4AP;UNC5CL;DAP

PAPOLA has several biochemical functions, for example, ATP binding, RNA binding, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAPOLA itself. We selected most functions PAPOLA had, and list some proteins which have the same functions with PAPOLA. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	TGFBR1A;SETX;CAMKVB;MYO6;MKNK2B;NLRP9C;CAMK1GA;ERBB3A;HARS
RNA binding	IFIT10;PRDM14;ZFML;IFIT1;ENDOU;PABPN1;RBM24A;SYNCRIP;RPS25
magnesium ion binding	TSSK2;FIGNL1;ADPRH;DCTPP1;COMTA;DOM3Z;PINK1;CLYBL;ATP10A
manganese ion binding	PPEF1;PPM1AB;ARG1;GALNT1;PRIMPOL;TDP2B;NUDT16;NPEPL1;FEN1
polynucleotide adenylyltransferase activity	PAPD7;PAPOLG;MTPAP;TUT1;PAPOLA;PAPD4;PAPOLB
protein binding	HIST1H2BE;KTN1;AUNIP;FBN2;SPEF2;PRPS1;EREG;RAD21;TNFSF13B

PAPOLA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAPOLA here. Most of them are supplied by our site. Hope this information will be useful for your research of PAPOLA.

Ywhae; PKM; REL; SMAD2; glpD; RSRC1; NPM1; CPSF1; CIRBP; PCBP2

de la Camara, CMF; Olivares-Gonzalez, L; et al. Infliximab reduces Zaprinast-induced retinal degeneration in cultures of porcine retina. JOURNAL OF NEUROINFLAMMATION 11:-(2014).

Meng, XW; Koh, BD; et al. Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression. JOURNAL OF BIOLOGICAL CHEMISTRY 289:20543-20558(2014).