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PBX1

  • Official Full Name

    pre-B-cell leukemia homeobox 1

  • Overview

    The Pbxs (Pre-B cell leukemia transcription factors) belong to the Three Amino Acid Loop Extension (TALE) family of homeodomain containing protein. Pbx1 has two isoforms, Pbx1a and 1b, that are divergent in sequence at the carboxy terminus, which is a res
  • Synonyms

    PBX1; pre-B-cell leukemia homeobox 1; pre B cell leukemia transcription factor 1; pre-B-cell leukemia transcription factor 1; homeobox protein PRL; homeobox protein PBX1; MGC126627; DKFZp686B09108;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PBX1-3408HCL Recombinant Human PBX1 293 Cell Lysate HEK293 N/A
Human PBX1-2878H Recombinant Human PBX1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PBX1-2498H Recombinant Human PBX1 protein, His-tagged E.coli His 1-349 aa
Mouse PBX1-12406M Recombinant Mouse PBX1 Protein Mammalian Cell His
Mouse PBX1-6526M-B Recombinant Mouse PBX1 Protein Pre-coupled Magnetic Beads HEK293
Mouse PBX1-6526M Recombinant Mouse PBX1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pbx1-4692M Recombinant Mouse Pbx1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Chicken PBX1-6311C Recombinant Chicken PBX1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PBX1 Related Articles

PBX1 involved in several pathways and played different roles in them. We selected most pathways PBX1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PBX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Transcriptional misregulation in cancerDEFA3;RELA;MDM2;HIST1H3I;Bcl2a1b;HIST1H3D;PRCC;SPINT1;PAX3

PBX1 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PBX1 itself. We selected most functions PBX1 had, and list some proteins which have the same functions with PBX1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingDLX2B;HIST1H2AA;GM14482;ZFP667;HNF1A;EBF3A;ZFAND5A;GPBP1;NFIX
RNA polymerase II core promoter proximal region sequence-specific DNA bindingPBX1;MZF1;RBPJ;BATF3;HOXA2;NKX6-1;RFX8;NACC2;TFAM
protein bindingMYLIPA;ATP2B4;ACTL8;FBXO33;STOML2;TLR1;VDR;FRAS1;ZNF524
protein heterodimerization activityHIST1H2BD;HIST1H2BM;SOX32;GCLM;NFE2L2A;POLE4;TBX15;HIST1H2BA;CEBPE
transcription factor activity, sequence-specific DNA bindingTFAM;HOXB2A;NFIL3-5;GATA5;POU5F2;FOXO3;ZFP13;RCAN1;FOXN4
transcription factor bindingSRY;TMEM173;RNF222;SUMO1;PRKDC;HES6;ADD1;NR0B1;PURB
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingBATF;PATZ1;ZIC1;TFE3B;PITX2;FOXL2;SOX1;ARNT2;ELF4

PBX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PBX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PBX1.

FOXC1; HOXB1; MEIS2; MEIS2; Hoxa1; PBX2; MEIS1

Wang, KP; Zhao, LQ; et al. Differential co-expression analysis of rheumatoid arthritis with microarray data. MOLECULAR MEDICINE REPORTS 10:2421-2426(2014).
Kiyokawa, N; Iijima, K; et al. Significance of CD66c expression in childhood acute lymphoblastic leukemia. LEUKEMIA RESEARCH 38:42-48(2014).
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