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PCDHB14

Official Full Name

protocadherin beta 14
Overview

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3 exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.
Synonyms

PCDHB14; protocadherin beta 14; protocadherin beta-14; PCDH BETA14; MGC120065; PCDHB 14; PCDH-beta-14; OTTHUMP00000160019; PCDH-BETA14;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Mouse	PCDHB14-12448M	Recombinant Mouse PCDHB14 Protein	Mammalian Cell	His		Inquiry
Mouse	PCDHB14-6544M	Recombinant Mouse PCDHB14 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PCDHB14-6544M-B	Recombinant Mouse PCDHB14 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Pcdhb14-1915M	Recombinant Mouse Pcdhb14 Protein, His-tagged	E.coli	N-His	Thr30-Arg189	Inquiry

Involved Pathway
Protein Function
Interacting Protein
PCDHB14 Related Articles

PCDHB14 involved in several pathways and played different roles in them. We selected most pathways PCDHB14 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PCDHB14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PCDHB14 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCDHB14 itself. We selected most functions PCDHB14 had, and list some proteins which have the same functions with PCDHB14. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	MYL9A;S100P;SLIT1B;F9A;PCDHB5;EMR4;LTBP2;PLCD1B;SNCB

PCDHB14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCDHB14 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCDHB14.

van Helden, YGJ; Godschalk, RWL; et al. Organ specificity of beta-carotene induced lung gene-expression changes in Bcmo1(-/-) mice. MOLECULAR NUTRITION & FOOD RESEARCH 57:307-319(2013).

O'Leary, R; Reilly, JE; et al. A variable cytoplasmic domain segment is necessary for gamma-protocadherin trafficking and tubulation in the endosome/lysosome pathway. MOLECULAR BIOLOGY OF THE CELL 22:4362-4372(2011).