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PDK3

  • Official Full Name

    pyruvate dehydrogenase kinase, isozyme 3

  • Overview

    The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the;overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the;tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose;metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and;phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate;dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is;predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding;different isoforms have been found for this gene.
  • Synonyms

    PDK3; pyruvate dehydrogenase kinase, isozyme 3; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial; mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3; PDK3_HUMAN; Pyruvate dehydrogenase kinase isoform 3; Pyruvate dehydrogenase kinase isozyme 3; Pyruvate dehydrogenase lipoamide kinase isozyme 3 mitochondrial; pyruvate dehydrogenase kinase, isoenzyme 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDK3-1072H Active Recombinant Human PDK3, GST-tagged Sf9 Insect Cell GST Full Length
Human PDK3-652H Recombinant Human PDK3, His-tagged E.coli His
Human PDK3-1072 Recombinant Human PDK3 protein, GST-tagged Insect Cell GST Full Length
Human PDK3-3328HCL Recombinant Human PDK3 293 Cell Lysate HEK293 N/A
Human PDK3-2713H Recombinant Human PDK3 protein, His-tagged E.coli His 129-369 aa
Human PDK3-2876HF Active Recombinant Full Length Human PDK3 Protein, GST-tagged Insect (sf21) GST 1-406
Human PDK3-5576H Recombinant Human PDK3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Pdk3-8051M Recombinant Mouse Pdk3 protein, His-tagged E.coli His Gly138~Pro396
Mouse Pdk3-4732M Recombinant Mouse Pdk3 protein, His-tagged E.coli His 131-362aa
Mouse Pdk3-4768M Recombinant Mouse Pdk3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Chicken PDK3-1406C Recombinant Chicken PDK3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PDK3 Related Research Area

PDK3 involved in several pathways and played different roles in them. We selected most pathways PDK3 participated on our site, such as Metabolism, Pyruvate metabolism, Pyruvate metabolism and Citric Acid (TCA) cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MetabolismSLC5A9;SIN3B;CYP2K19;SLC23A2;COX6C;ALOX5AP;TACO1;ELOVL1A;GSTO2
Pyruvate metabolismMDH2;ME3;PDHA2;LDHAL6B;ACAT1;ALDH3A2A;ALDH9A1A.1;ALDH7A1;PKM
Pyruvate metabolism and Citric Acid (TCA) cyclePDK3;PDP1;BRP44;PDP2;PDK4;PDK3B;PDK2;ADHFE1;SLC16A8
Regulation of pyruvate dehydrogenase (PDH) complexPDK2B;PDP1;PDK3;PDK4;PDK3B;PDK2;PDP2;PDPR
Signal TransductionNF2A;DRAP1;OPN4;FSTL1B;RGS1;GPR55A;PTH2;CRABP2A;GDI1
Signaling by Retinoic AcidPDK2B;RDH10;DHRS4;CRABP1B;RARGA;CRABP2;RDH13;SDR16C5;DHRS3A
The citric acid (TCA) cycle and respiratory electron transportMPC1;C20orf7;NDUFAF7;ETFB;COX14;COX16;NDUFAF2;FAM36A;PDP2

PDK3 has several biochemical functions, for example, ATP binding, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDK3 itself. We selected most functions PDK3 had, and list some proteins which have the same functions with PDK3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMAP3K9;NLK1;STK39;CDKL3;SPATA5L1;TAOK1;CAMK2D2;TCP1;P2RX1
protein bindingHMGCR;RAB5C;UBLCP1;ZCCHC12;WDR48;NR2C1;AP5S1;GEMIN6;MS4A3
protein kinase activityMMD;TEK;MOK;HIPK3A;CSNK1DA;RIPK3;RAF1;SGK196;CSNK1DB
protein serine/threonine kinase activityPKMYT1;PKN1;PAK6;DYRK2;MINK1;CLK1;GSK3B;RPS6KC1;PAK7
pyruvate dehydrogenase (acetyl-transferring) kinase activityPDK1;PDK4;PDK2;PDK3

PDK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDK3.

EGFR; linkable vandetanib analogue; ECD; TCP1; CCT6A; UTRN; CCT5; CCT3; CCT8; CCT4; VCP; CCT2; ICT1; HLTF; ACAP2; PDK1; CLPP; UBR7; CCT7

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