PDZD2

Official Full Name

PDZ domain containing 2

Background

Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.

Synonyms

PDZD2; PDZ domain containing 2; PDZ domain containing 3 , PDZK3; PDZ domain-containing protein 2; KIAA0300; Activated in prostate cancer protein; AIPC; Likely ortholog of rat plakophilin related armadillo repeat protein interacting PDZ protein; PAPIN; PDZ domain containing 3; PDZ domain containing protein 2; PDZ domain containing protein 3; PDZK 3; PIN1; Plakophilin related armadillo repeat protein interacting PDZ protein like; Rat plakophilin related armadillo repeat protein interacting PDZ protein like; PDZ domain-containing protein 3; PDZK3