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PDZD3

Official Full Name

PDZ domain containing 3
Overview

Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421),followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 (PubMed 11950846)).
Synonyms

PDZD3; PDZ domain containing 3; PDZ domain containing 2 , PDZK2; Na(+)/H(+) exchange regulatory cofactor NHE-RF4; FLJ22756; IKEPP; Intestinal and kidney enriched PDZ protein; Intestinal and kidney-enriched PDZ protein; Na/Pi cotransporter C-terminal-associated protein 2; NaPi-Cap2; Natrium-phosphate cotransporter IIa C-terminal-associated protein 2; NHERF-4; NHRF4_HUMAN; PDZ domain containing protein 2; PDZ domain-containing protein 2; PDZ domain-containing protein 3; PDZD 3; PDZK2; Protein DLNB27; Sodium-hydrogen exchanger regulatory factor 4; PDZ domain containing 2; NHERF4;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	PDZD3-3314HCL	Recombinant Human PDZD3 293 Cell Lysate	HEK293	N/A	Inquiry
Mouse	PDZD3-12608M	Recombinant Mouse PDZD3 Protein	Mammalian Cell	His	Inquiry
Mouse	PDZD3-6622M	Recombinant Mouse PDZD3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	PDZD3-6622M-B	Recombinant Mouse PDZD3 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PDZD3 Related Articles

PDZD3 involved in several pathways and played different roles in them. We selected most pathways PDZD3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PDZD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PDZD3 has several biochemical functions, for example, guanylate cyclase inhibitor activity, ion channel inhibitor activity, protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDZD3 itself. We selected most functions PDZD3 had, and list some proteins which have the same functions with PDZD3. You can find most of the proteins on our site.

Function	Related Protein
guanylate cyclase inhibitor activity	PDZD3;PDZD3B
ion channel inhibitor activity	PDZD3;KCNV1;ENSA;STOML1;GNB2L1;KCNMB2;RSC1A1
protein C-terminus binding	CITED1;IFT52;PICK1;PEX1;KCNK3;HIC2;CACNA1B;SNF8;SP1
protein binding	NCAPH;CENPP;CEP120;S100B;AKAP1;GCA;ATXN7L1;SHMT2;TUBGCP3

PDZD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDZD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDZD3.

CACNA1S; SPRYD7; ASAP3; SLC41A3

O'Leary, PC; Penny, SA; et al. Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer. BMC CANCER 13:-(2013).

Boon, SS; Banks, L; et al. High-Risk Human Papillomavirus E6 Oncoproteins Interact with 14-3-3 zeta in a PDZ Binding Motif-Dependent Manner. JOURNAL OF VIROLOGY 87:1586-1595(2013).