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PEX1

Official Full Name

peroxisomal biogenesis factor 1
Overview

This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome.
Synonyms

PEX1; peroxisomal biogenesis factor 1; peroxisome biogenesis factor 1 , Zellweger syndrome , Zellweger syndrome 1 , ZWS, ZWS1; peroxisome biogenesis factor 1; Highly similar to ATPase [H.sapiens]; Peroxin 1; Peroxin-1; peroxin1; Peroxisome biogenesis disorder protein 1; PEX1_HUMAN; ZWS1; Zellweger syndrome; ZWS;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PEX1-577H	Recombinant Human PEX1	Mammalian Cell	His		Inquiry
Human	PEX1-1648H	Recombinant Human PEX1, His-tagged	E.coli	His	C-term-357aa	$319 / 25ug
Human	PEX1-1335HCL	Recombinant Human PEX1 cell lysate		N/A		Inquiry
Human	PEX1-3828H-B	Recombinant Human PEX1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	PEX1-3828H	Recombinant Human PEX1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	PEX1-4864H	Recombinant Human PEX1 Protein (Glu62-Gln219), N-His tagged	E.coli	N-His	Glu62-Gln219	Inquiry
Mouse	Pex1-8029M	Recombinant Mouse Pex1 protein, His & T7-tagged	E.coli	His/T7	Asn172~Ala377 (Accession # Q5BL07)	Inquiry
Zebrafish	PEX1-7654Z	Recombinant Zebrafish PEX1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PEX1 Related Articles

PEX1 involved in several pathways and played different roles in them. We selected most pathways PEX1 participated on our site, such as Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PEX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Peroxisome	MPV17L;AGPS;NUDT12;PEX7;PEX11C;PEX16;NOS2;BAAT;PEX1

PEX1 has several biochemical functions, for example, ATP binding, ATPase activity, coupled, protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PEX1 itself. We selected most functions PEX1 had, and list some proteins which have the same functions with PEX1. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	ENTPD8;CLCN6;NEK11;FAM20B;ABCB9;EIF2B2;PLK1;STK10;NME2B.1
ATPase activity, coupled	ABCB1A;VPS4A;HSPA6;NSF;HSP104;HSPA8;VPS4B;HSPA1A;HSPA1B
protein C-terminus binding	DDX1;PLEKHB1;DLG3;CDC20;CAV3;CDK7;SHANK1;STIP1;AP2A1
protein binding	GLDN;LRP12;CENPH;ZNF227;ATRIP;PPID;ROS1;ANO2;SMARCA5
protein complex binding	PTCH1;RAP1B;SKIL;GIT2;DISC1;RAN;BAX;ARRB2;DLG4

PEX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PEX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PEX1.

PEX6; PEX14; EXOSC2; SMC1A; PEX26

Miyata, N; Okumoto, K; et al. AWP1/ZFAND6 Functions in Pex5 Export by Interacting with Cys-Monoubiquitinated Pex5 and Pex6 AAA ATPase. TRAFFIC 13:168-183(2012).

Lamhonwah, AM; Ackerley, CA; et al. OCTN3 is a mammalian peroxisomal membrane carnitine transporter. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 338:1966-1972(2005).