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PFKL

Official Full Name

phosphofructokinase, liver
Overview

Phosphofructokinase (PFK) catalyzes the phosphorylation of fructose-6-phosphate in glycolysis. There are three isozymes: muscle-type, liver-type, and platelet-type. The liver-type PFK (PFKL) is the predominant subunit of PFK found in the liver . Research
Synonyms

PFKL; phosphofructokinase, liver; 6-phosphofructokinase, liver type; phosphohexokinase; phosphofructokinase 1; liver-type 1-phosphofructokinase; phosphofructo-1-kinase isozyme B; PFK-B; FLJ30173; FLJ40909; DKFZp686G1648; DKFZp686L2097;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PFKL-1657H	Recombinant Human PFKL, GST-tagged	E.coli	GST	424-780aa	$319 / 25ug
Human	PFKL-1658H	Recombinant Human PFKL protein, GST-tagged	Wheat Germ	GST	1 a.a. - 827 a.a.	Inquiry
Human	PFKL-3272HCL	Recombinant Human PFKL 293 Cell Lysate	HEK293	N/A		Inquiry
Human	PFKL-3273HCL	Recombinant Human PFKL 293 Cell Lysate	HEK293	N/A		Inquiry
Human	PFKL-2581H	Recombinant Human PFKL Protein, His-tagged	E.coli	N-His	Ala2-His390	Inquiry
Human	PFKL-568HF	Recombinant Full Length Human PFKL Protein, GST-tagged	In Vitro Cell Free System	GST	827 amino acids	Inquiry
Mouse	PFKL-12664M	Recombinant Mouse PFKL Protein	Mammalian Cell	His		Inquiry
Mouse	PFKL-6653M	Recombinant Mouse PFKL Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PFKL-6653M-B	Recombinant Mouse PFKL Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	PFKL-4394R	Recombinant Rat PFKL Protein	Mammalian Cell	His		Inquiry
Rat	Pfkl-8012R	Recombinant Rat Pfkl protein, His & T7-tagged	E.coli	His/T7	Ala2~His390 (Accession # P30835)	Inquiry
Rat	PFKL-4054R	Recombinant Rat PFKL Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	PFKL-4054R-B	Recombinant Rat PFKL Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
PFKL Related Articles

PFKL involved in several pathways and played different roles in them. We selected most pathways PFKL participated on our site, such as Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Fructose and mannose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFKL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glycolysis / Gluconeogenesis	ALDH9A1A.1;PCK1;LDHBA;PCK2;PFKL;ACSS2L;GAPDHS;LDHC;ENO2
Pentose phosphate pathway	RPE;GPI;H6PD;PRPS1B;GPI1;ALDOB;ALDOCA;GPIB;ALDOC
Fructose and mannose metabolism	FPGT;TIGARA;HK2;PFKMB;FBP1;TIGARB;TPI1;ALDOCA;AKR1B8
Galactose metabolism	AKR1B1L;PFKL;HK3;PGM2;LALBA;GAA;GALT;GALE;G6PC
Metabolic pathways	HDC;NME7;PIGM;LPCAT4;PTDSS1A;CYP19A1;MIBP2;CYP2S1;ANPEPB
Carbon metabolism	MDH1AA;PHGDH;FBP1A;GPT;PKLR;PKMA;PSAT1;PRPS2;SDSL
Biosynthesis of amino acids	GM5506;ALDOAA;GOT2A;ALDOAB;IDH1;PFKL;GLULB;GOT2B;TPI1
RNA degradation	PABPC1A;ZCCHC7;PNPT1;PFKM;EXOSC10;LSM2;PFKP;TTC37;SKIV2L
HIF- signaling pathway	TCEB1;HK2;RELA;BCL2;NOS2;PDHA2;IGF1;MKNK2;TCEB2
AMPK signaling pathway	LIPE;GYS2;ULK1;PFKL;TSC2;PFKFB3;CRTC2;SCD5;CAB39L
Central carbon metabolism in cancer	PDGFRA;PFKP;RAF1;MAPK1;PGAM1;MET;NTRK1;PTEN;NTRK3

PFKL has several biochemical functions, for example, 6-phosphofructokinase activity, contributes_to 6-phosphofructokinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFKL itself. We selected most functions PFKL had, and list some proteins which have the same functions with PFKL. You can find most of the proteins on our site.

Function	Related Protein
6-phosphofructokinase activity	PFKMA;PFKMB;PFKL;PFKM;PFKP;PFKLB
contributes_to 6-phosphofructokinase activity
ATP binding	BMPR2B;CASK;UCKL1A;FER;GM711;VMHC;NME4;P2RX2;SMYHC3
fructose binding	PFKM;PFKL;ALDOA;ALDOB
fructose-6-phosphate binding	GCKR;PFKL;PFKFB1
identical protein binding	FNBP1;TNN;GUCY2E;NCAM1;B2M;G6PD;MAPK1IP1;TTR;BAIAP2
kinase binding	BCL10;PRPSAP1;BTG1;PARK7;PRKCD;GFAP;ABI2;CAB39;FAS
metal ion binding	TRP53;MGAT4A;CTCFL;CYP2K17;PVALB6;TROVE2;DCST1;ZNF329;MORC1
protein binding	SLC11A2;CAV3;PSMC3;RNF111;EPB41B;KRT20;BRCA2;PAIP1;CUBN

PFKL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFKL here. Most of them are supplied by our site. Hope this information will be useful for your research of PFKL.

PFKM; KRTAP5-9; KRTAP10-7; GTPBP3; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate

Shin, JH; Krapfenbauer, K; et al. Mass-spectrometrical analysis of proteins encoded on chromosome 21 in human fetal brain. AMINO ACIDS 31:435-447(2006).

Peled-Kamar, M; Degani, H; et al. Altered brain glucose metabolism in transgenic-PFKL mice with elevated L-phosphofructokinase: in vivo NMR studies. BRAIN RESEARCH 810:138-145(1998).