PHB
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Official Full Name
prohibitin
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Overview
The prohibitins, called PHB1 and PHB2, are highly conserved proteins that are present in multiple compartments in eukaryotic cells. PHB1 is 30kDa tumor suppressor protein involved in cell cycle control. PHB1 has been found in mitochondria, the nucleus and -
Synonyms
PHB; prohibitin; PHB1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Burkholderia pickettii
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- GST
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- PHB Related Articles
PHB involved in several pathways and played different roles in them. We selected most pathways PHB participated on our site, such as ARMS-mediated activation, Axon guidance, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
ARMS-mediated activation | AKAP9;NETO2;CSF2RA;NRG2A;FRS2B;SPRED3;FRS3;PHB;DAB2IPB |
Axon guidance | DPYSL4;PPP3CC;DUSP9;AP2M1;FRS2;KCNQ2;CSNK2A2;UNC5C;NRTN |
Cytokine Signaling in Immune system | FGFR1B;SPNA2;HLA-DQB2;UBE2L6;HERC5;TRIM38;TRIM6;TRIM3;RASGRP4 |
DAP12 interactions | KLB;SPRED3;MARK3;WDR83;KIR2DS2;DUSP1;CD300LB;LAMTOR2;DAB2IPB |
DAP12 signaling | FGFR1B;KLB;PAQR3A;AGO1;HBEGF;JAK3;KBTBD7;CNKSR1;FRS3 |
Developmental Biology | TRPC5;HIF3A;CDH4;FOXH1;JAK3;TCF4;ITGB1B.1;GFRA2;CRMP1 |
Downstream signal transduction | PEA15A;LAMTOR2;FRS3;SPTBN1;DUSP9;FGF18B;AGO1;TRAT1;SPRED3 |
Downstream signaling of activated FGFR1 | RASGEF1A;MARK3;IL17RD;KBTBD7;PEA15;DUSP9;SPRED2;SPNA1;PTPRA |
PHB has several biochemical functions, for example, RNA polymerase II transcription factor activity, sequence-specific DNA binding, complement component C3a binding, complement component C3b binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHB itself. We selected most functions PHB had, and list some proteins which have the same functions with PHB. You can find most of the proteins on our site.
Function | Related Protein |
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RNA polymerase II transcription factor activity, sequence-specific DNA binding | LMO2;JUN;EF1;PAX6B;NHLH2;SIM1B;ZNF434;FLI1B;MEF2A |
complement component C3a binding | C3AR1;PHB |
complement component C3b binding | CR1;PHB |
enzyme binding | PPP1R3B;STUB1;HMOX1;PAWR;PHKG2;KAT8;CCDC99;CPSF1;EHHADH |
histone deacetylase binding | ZNHIT1;XBP1;DNMT3B;DHX36;NKX2-5;RUNX2;SOD3;ANKRA2;RBBP4 |
protein C-terminus binding | CEP135;MED12;COIL;PHB2;DLG3;MID1IP1;DLG4;AXIN1;KCNJ11 |
protein binding | SCLY;CTBP2;CUTA;TRADD;NDUFB9;CACYBP;ERRFI1;C7orf25;SFTPC |
proteinase activated receptor binding | PDCD6IP;PHB;BICD1 |
transcription regulatory region DNA binding | ZNF613;ZFP821;CBX4;TP73;RREB1;GATA4;SALL1;SNCA;HNRNPL |
PHB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHB here. Most of them are supplied by our site. Hope this information will be useful for your research of PHB.
TP53; VCAM1; LONRF3; env; CHD2; ADAM10; XPO1
- Q&As
- Reviews
Q&As (6)
Ask a questionPHB proteins play an important role in cell signal transduction. It can act as a regulator of signal transduction pathways, influencing processes such as cell proliferation, differentiation, and apoptosis. The specific mechanism of action needs to be further studied.
The expression level of PHB protein can be detected by immunohistochemistry, western blotting, and real-time PCR. These techniques can detect protein or mRNA levels of PHB proteins in tissues or cells to assess changes in their expression in disease.
PHB proteins are mainly localized in the inner mitochondrial membrane and nucleus. It plays a role in regulating mitochondrial function and structure on the inner mitochondrial membrane and is involved in processes such as gene transcription and DNA damage repair in the nucleus.
PHB proteins have a variety of biological functions. It is involved in mitochondrial biogenesis and regulates mitochondrial number and function, participates in the process of cell proliferation and apoptosis, affects cell growth and death, and also participates in nuclear activities such as gene transcription and DNA damage repair.
Therapeutic strategies for PHB proteins include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against PHB proteins to inhibit their aberrant activity in diseases, or the regulation of PHB protein expression through gene knockout or overexpression techniques.
There is an interaction between PHB protein and other proteins. It can interact with mitochondria-related proteins to regulate mitochondrial function and structure, and can also interact with nucleus-related proteins to participate in processes such as gene transcription and DNA damage repair.
Customer Reviews (3)
Write a reviewThe catalytic activity is amazing, and the mild nature of the mild nature is appreciated for the highly efficient catalysis achieved under mild conditions.
We like the purity and precision of their products, and the results are accurate and reliable.
Their protein production process is strictly controlled, and the quality of products is guaranteed.
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