Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

PHB

  • Official Full Name

    prohibitin

  • Overview

    The prohibitins, called PHB1 and PHB2, are highly conserved proteins that are present in multiple compartments in eukaryotic cells. PHB1 is 30kDa tumor suppressor protein involved in cell cycle control. PHB1 has been found in mitochondria, the nucleus and
  • Synonyms

    PHB; prohibitin; PHB1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Burkholderia pickettii
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
  • GST
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PHB-29709TH Recombinant Human PHB Wheat Germ N/A 272 amino acids
Human PHB-181H Recombinant Human PHB protein, T7/His-tagged E.coli T7/His
Human PHB-7543H Recombinant Human PHB, His-tagged E.coli His 1-272aa
Human PHB-3241HCL Recombinant Human PHB 293 Cell Lysate HEK293 N/A
Human PHB-371HF Recombinant Full Length Human PHB Protein In Vitro Cell Free System 272 amino acids
Human PHB-4887H Recombinant Human PHB Protein (Lys177-Gln272), N-His tagged E.coli N-His Lys177-Gln272
Human PHB-1938H Recombinant Human PHB Protein, His&GST-tagged E.coli N-His&GST Met1-Gln272
Human PHB-1257H Recombinant Human PHB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse PHB-12708M Recombinant Mouse PHB Protein Mammalian Cell His
Mouse PHB-2606M Recombinant Mouse PHB Protein (41-173 aa), His-tagged E.coli His 41-173 aa
Mouse PHB-6677M Recombinant Mouse PHB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Phb-4832M Recombinant Mouse Phb Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Phb-3337M Recombinant Mouse Phb protein, His-tagged E.coli His 174-272aa
Mouse Phb-3336M Recombinant Mouse Phb protein, His-tagged E.coli His 1-40aa
Mouse PHB-6677M-B Recombinant Mouse PHB Protein Pre-coupled Magnetic Beads HEK293
Rat PHB-4417R Recombinant Rat PHB Protein Mammalian Cell His
Rat PHB-4077R Recombinant Rat PHB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PHB-4077R-B Recombinant Rat PHB Protein Pre-coupled Magnetic Beads HEK293
Burkholderia pickettii PHB-3855B Recombinant Burkholderia pickettii PHB protein, His-tagged E.coli His 28-488aa
Rhesus Macaque PHB-3400R Recombinant Rhesus monkey PHB Protein, His-tagged Mammalian Cell His
Rhesus Macaque PHB-3218R Recombinant Rhesus Macaque PHB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PHB-3218R-B Recombinant Rhesus Macaque PHB Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PHB-11445Z Recombinant Zebrafish PHB Mammalian Cell His
Chicken PHB-4088C Recombinant Chicken PHB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PHB Related Articles

PHB involved in several pathways and played different roles in them. We selected most pathways PHB participated on our site, such as ARMS-mediated activation, Axon guidance, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationAKAP9;NETO2;CSF2RA;NRG2A;FRS2B;SPRED3;FRS3;PHB;DAB2IPB
Axon guidanceDPYSL4;PPP3CC;DUSP9;AP2M1;FRS2;KCNQ2;CSNK2A2;UNC5C;NRTN
Cytokine Signaling in Immune systemFGFR1B;SPNA2;HLA-DQB2;UBE2L6;HERC5;TRIM38;TRIM6;TRIM3;RASGRP4
DAP12 interactionsKLB;SPRED3;MARK3;WDR83;KIR2DS2;DUSP1;CD300LB;LAMTOR2;DAB2IPB
DAP12 signalingFGFR1B;KLB;PAQR3A;AGO1;HBEGF;JAK3;KBTBD7;CNKSR1;FRS3
Developmental BiologyTRPC5;HIF3A;CDH4;FOXH1;JAK3;TCF4;ITGB1B.1;GFRA2;CRMP1
Downstream signal transductionPEA15A;LAMTOR2;FRS3;SPTBN1;DUSP9;FGF18B;AGO1;TRAT1;SPRED3
Downstream signaling of activated FGFR1RASGEF1A;MARK3;IL17RD;KBTBD7;PEA15;DUSP9;SPRED2;SPNA1;PTPRA

PHB has several biochemical functions, for example, RNA polymerase II transcription factor activity, sequence-specific DNA binding, complement component C3a binding, complement component C3b binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHB itself. We selected most functions PHB had, and list some proteins which have the same functions with PHB. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II transcription factor activity, sequence-specific DNA bindingLMO2;JUN;EF1;PAX6B;NHLH2;SIM1B;ZNF434;FLI1B;MEF2A
complement component C3a bindingC3AR1;PHB
complement component C3b bindingCR1;PHB
enzyme bindingPPP1R3B;STUB1;HMOX1;PAWR;PHKG2;KAT8;CCDC99;CPSF1;EHHADH
histone deacetylase bindingZNHIT1;XBP1;DNMT3B;DHX36;NKX2-5;RUNX2;SOD3;ANKRA2;RBBP4
protein C-terminus bindingCEP135;MED12;COIL;PHB2;DLG3;MID1IP1;DLG4;AXIN1;KCNJ11
protein bindingSCLY;CTBP2;CUTA;TRADD;NDUFB9;CACYBP;ERRFI1;C7orf25;SFTPC
proteinase activated receptor bindingPDCD6IP;PHB;BICD1
transcription regulatory region DNA bindingZNF613;ZFP821;CBX4;TP73;RREB1;GATA4;SALL1;SNCA;HNRNPL

PHB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHB here. Most of them are supplied by our site. Hope this information will be useful for your research of PHB.

TP53; VCAM1; LONRF3; env; CHD2; ADAM10; XPO1

Bavelloni, A; Piazzi, M; et al. Prohibitin 2 represents a novel nuclear AKT substrate during all-trans retinoic acid-induced differentiation of acute promyelocytic leukemia. FASEB JOURNAL 28:2009-2019(2014).
Chen, SX; Parlane, NA; et al. New Skin Test for Detection of Bovine Tuberculosis on the Basis of Antigen-Displaying Polyester Inclusions Produced by Recombinant Escherichia coli. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 80:2526-2535(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is the role of PHB proteins in cell signaling? 11/02/2022

PHB proteins play an important role in cell signal transduction. It can act as a regulator of signal transduction pathways, influencing processes such as cell proliferation, differentiation, and apoptosis. The specific mechanism of action needs to be further studied.

How can I detect the expression level of PHB protein? 04/16/2022

The expression level of PHB protein can be detected by immunohistochemistry, western blotting, and real-time PCR. These techniques can detect protein or mRNA levels of PHB proteins in tissues or cells to assess changes in their expression in disease.

Where is PHB protein located in cells? 10/21/2021

PHB proteins are mainly localized in the inner mitochondrial membrane and nucleus. It plays a role in regulating mitochondrial function and structure on the inner mitochondrial membrane and is involved in processes such as gene transcription and DNA damage repair in the nucleus.

What are the biological functions of PHB proteins? 08/24/2020

PHB proteins have a variety of biological functions. It is involved in mitochondrial biogenesis and regulates mitochondrial number and function, participates in the process of cell proliferation and apoptosis, affects cell growth and death, and also participates in nuclear activities such as gene transcription and DNA damage repair.

What are the therapeutic strategies for PHB protein? 03/26/2020

Therapeutic strategies for PHB proteins include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against PHB proteins to inhibit their aberrant activity in diseases, or the regulation of PHB protein expression through gene knockout or overexpression techniques.

Are interactions between PHB proteins and other proteins present? 12/02/2019

There is an interaction between PHB protein and other proteins. It can interact with mitochondria-related proteins to regulate mitochondrial function and structure, and can also interact with nucleus-related proteins to participate in processes such as gene transcription and DNA damage repair.

Customer Reviews (3)

Write a review
Reviews
08/12/2023

    The catalytic activity is amazing, and the mild nature of the mild nature is appreciated for the highly efficient catalysis achieved under mild conditions.

    06/16/2023

      We like the purity and precision of their products, and the results are accurate and reliable.

      07/03/2021

        Their protein production process is strictly controlled, and the quality of products is guaranteed.

        Ask a Question for All PHB Products

        Required fields are marked with *

        My Review for All PHB Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends