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PHLPP2

  • Official Full Name

    PH domain and leucine rich repeat protein phosphatase 2

  • Overview

    PHLPP2 contains 21 LRR (leucine rich) repeats, 1 PH domain and 1 PP2C like domain. It is a protein phosphatase that specifically mediates dephosphorylation of AKT1 Ser 473, a protein that regulates the balance between cell survival and apoptosis through
  • Synonyms

    PHLPP2; PH domain and leucine rich repeat protein phosphatase 2; PH domain and leucine rich repeat protein phosphatase like , PHLPPL; PH domain leucine-rich repeat-containing protein phosphatase 2; KIAA0931; PH domain leucine rich repeat protein phosphatase like; PHLPP like; PHLPPL;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PHLPP2-7012H Recombinant Human PHLPP2, GST-tagged E.coli GST 766-1043 aa
Human PHLPP2-1615 Recombinant Human PHLPP2 protein, GST-tagged E.coli GST 766-1043
Human PHLPP2-1615H Recombinant Human PHLPP2, GST-tagged E.coli GST 766-1043
Human PHLPP2-1690H Recombinant Human PHLPP2, His-tagged E.coli His 575-781aa
Human PHLPP2-2720H Recombinant Human PHLPP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PHLPP2-1670H Recombinant Human PHLPP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PHLPP2-1843HFL Recombinant Full Length Human PHLPP2 Protein, C-Flag-tagged Mammalian cells Flag
Human PHLPP2-1670H-B Recombinant Human PHLPP2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Phlpp2-4843M Recombinant Mouse Phlpp2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish PHLPP2-5880Z Recombinant Zebrafish PHLPP2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PHLPP2 involved in several pathways and played different roles in them. We selected most pathways PHLPP2 participated on our site, such as PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHLPP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PIK-Akt signaling pathwayIL3;LPAR4;ITGA2;Il4ra;FGF1;FGF21;PIK3CB;CCNE2;TLR4

PHLPP2 has several biochemical functions, for example, metal ion binding, protein serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PHLPP2 itself. We selected most functions PHLPP2 had, and list some proteins which have the same functions with PHLPP2. You can find most of the proteins on our site.

Function Related Protein
metal ion bindingTRIM35-7;ZFP827;ZFP146;ZRANB3;MGAT5B;ZFP637;RNF144AA;CYP2X9;ESR2A
protein serine/threonine phosphatase activityPPM1G;CDC14A;PPP2R2A;CDC14AB;PDP1;PDP2;PPM1LB;PPM1N;PPP3CB

PHLPP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHLPP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHLPP2.

PRKCB; SLC9A3R1; PHLPP1; USP12; USP1; EZR; RDX; USP46; SLC9A3R2; Scrib; WDR48; WDR20; SNX27; VAT1; RPS6KB1

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