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PIGK

Official Full Name

phosphatidylinositol glycan anchor biosynthesis, class K
Overview

This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.
Synonyms

PIGK; phosphatidylinositol glycan anchor biosynthesis, class K; phosphatidylinositol glycan, class K; GPI-anchor transamidase; GPI transamidase subunit; GPI8; hGPI8; PIG-K; GPI8 homolog; phosphatidylinositol-glycan biosynthesis class K protein; MGC22559;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PIGK-1706H	Recombinant Human PIGK, His-tagged	E.coli	His	N-term-332aa	$319 / 25ug
Human	PIGK-3197HCL	Recombinant Human PIGK 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	PIGK-12781M	Recombinant Mouse PIGK Protein	Mammalian Cell	His		Inquiry
Mouse	PIGK-6724M	Recombinant Mouse PIGK Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PIGK-6724M-B	Recombinant Mouse PIGK Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	PIGK-3427R	Recombinant Rhesus monkey PIGK Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	PIGK-3245R-B	Recombinant Rhesus Macaque PIGK Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	PIGK-3245R	Recombinant Rhesus Macaque PIGK Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	PIGK-373Z	Recombinant Zebrafish PIGK	Mammalian Cell	His		Inquiry
Chicken	PIGK-2935C	Recombinant Chicken PIGK	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PIGK Related Research Area

PIGK involved in several pathways and played different roles in them. We selected most pathways PIGK participated on our site, such as Attachment of GPI anchor to uPAR, Glycosylphosphatidylinositol(GPI)-anchor biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIGK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Attachment of GPI anchor to uPAR
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis	PIGL;GPLD1;PIGA;DPM2;GPAA1;PIGX;PIGV;PIGC;PIGQ
Metabolic pathways	CYP2J2;PPAP2C;TKTB;EPHX2;ALOX5A;TH;CCBL2;SPTLC1;HIBADH
Metabolism of proteins	APCS;ARSH;EXOC3;IGFBP5B;DCP2;PPP6C;GPR116;KDELR3;FBXW9
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification	SLC35A1;GALNT6;DPH2;NANP;MPDU1;ZNF408;CTAGE5;ALG14;GALNT13

PIGK has several biochemical functions, for example, contributes_to GPI anchor binding, GPI-anchor transamidase activity, cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIGK itself. We selected most functions PIGK had, and list some proteins which have the same functions with PIGK. You can find most of the proteins on our site.

Function	Related Protein
contributes_to GPI anchor binding	PIGK;GPAA1
GPI-anchor transamidase activity	NUDT13;FAM108C;PIGK;FAM108A;PIGU;MBLAC1;FAM108B
cysteine-type peptidase activity	SENP7B;CTSL1B;DUB1;OTULIN;SENP7;CTSH;ALG13;CASPA;CASPBL
protein binding	NME2;FKBP4;ACHE;HSPA8;KLF10;RNF170;SYT11;PPIC;COX5A
protein disulfide isomerase activity	ERO1L;TMX3;PDIA5;PDIA4;GLRX2;TMX4;PIGK;ITGB3;PDIA2

PIGK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIGK here. Most of them are supplied by our site. Hope this information will be useful for your research of PIGK.

ALPP; midostaurin; PIGS

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