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PIK3R3

  • Official Full Name

    phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

  • Overview

    Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme that in humans is encoded by the PIK3R3 gene.
  • Synonyms

    PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma); phosphatidylinositol 3-kinase regulatory subunit gamma; p55; p55PIK; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; 100% homology to SWISS-PROT Q92569; PI3-kinase regulatory su;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PIK3R3-3184HCL Recombinant Human PIK3R3 293 Cell Lysate HEK293 N/A
Human PIK3R3-3673H Recombinant Human PIK3R3 protein, GST-tagged E.coli GST 312-382 aa
Human PIK3R3-2213H Recombinant Human PIK3R3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PIK3R3-0148H Recombinant Human PIK3R3 Protein (Y2-R461), His/GST tagged Insect Cell His/GST Y2-R461
Human PIK3R3-0147H Recombinant Human PIK3R3 Protein (Y2-R461), Tag Free Insect Cell No tag Y2-R461
Mouse Pik3r3-4866M Recombinant Mouse Pik3r3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PIK3R3-4464R Recombinant Rat PIK3R3 Protein Mammalian Cell His
Rat PIK3R3-4124R Recombinant Rat PIK3R3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PIK3R3-4124R-B Recombinant Rat PIK3R3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PIK3R3-3436R Recombinant Rhesus monkey PIK3R3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PIK3R3-3254R-B Recombinant Rhesus Macaque PIK3R3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PIK3R3-3254R Recombinant Rhesus Macaque PIK3R3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PIK3R3 involved in several pathways and played different roles in them. We selected most pathways PIK3R3 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayMAP2K2A;PAK7;HRASB;BRAF;PRKCBA;SHC1;GRB2;PIK3CB;EGFRA
Ras signaling pathwayFGF12;FGF8;PDGFB;SHC2;CALM3;RALBP1;REL;GAB2;RRAS
Rap signaling pathwayPARD3;LPAR5;RAP1A;ITGAM;PIK3R1;ANGPT1;LPAR2;HRAS;VEGFB
cGMP-PKG signaling pathwayVDAC3;CREB3L2;ATP2B1;ATF4;MAP2K1;Adcy4;CALM1;MEF2D;PDE3B
cAMP signaling pathwayAKT1;Adcy4;CAMK2G;PIK3R1;PIK3CG;NFKB1;FFAR2;GRIN3A;ATP1B1
Chemokine signaling pathwayCCL8;CXCL8;CCL3L1;MAPK1;CCR9;RELA;PLCB1;CCL23;GNG7
HIF- signaling pathwayPDHA2;PDK1;ENO2;MAPK1;BCL2;INS1;NPPA;RPS6KB2;TFRC
FoxO signaling pathwaySGK1;NLK;SMAD3A;USP7;PRKAG1;PIK3R2;SMAD4;GADD45BB;GADD45AB
Phosphatidylinositol signaling systemPIK3R1;MTMR7B;PIP4K2AA;CDS2;PLCG1;PLCD1;PIK3C2B;ITPK1A;CALML3
Sphingolipid signaling pathwayASAH1;PPP2R2A;CERS4;PRKCB;NFKB1;MAPK12;TNFRSF1A;PPP2R5B;CERS2
Phospholipase D signaling pathwayGNAS;PIK3CD;RALGDS;MS4A2;MAPK1;INS1;PDGFC;PIK3R2;PLCG2
mTOR signaling pathwayCAB39L1;PRKCBB;EIF4E1B;RB1CC1;PRKCG;RRAGC;RPS6KA3B;VEGFA;MAPK1
PIK-Akt signaling pathwayFGF2;HSP90B1;LPAR6;ITGB8;TSC2;RELA;GNG4;PPP2R2A;RBL2
AMPK signaling pathwayRPS6KB2;IRS2;CREB3L3;PPARGC1A;AKT2;G6PC3;PPP2R2D;CPT1A;PIK3R2
ApoptosisBAXA;PANK1A;CDK5RAP2;IL1R1;CASP9;IRF4A;CASP3B;TNFRSFA;FADD
Adrenergic signaling in cardiomyocytesSLC8A1;GNA15.1;ATP2B2;CACNA1D;ADRB2;ADCY7;TNNC1A;CALM;TNNC1B
VEGF signaling pathwayPTK2AB;MAPKAPK2;PLA2G4AA;RAC3A;PPP3CCB;PIK3CB;PIK3R2;HRASB;RAC3B
Osteoclast differentiationTREM2;SIRPA;SIRPB1;IKBKB;PPP3R1;LILRA4;CAMK4;SPI1;AKT2
Focal adhesionPPP1CB;VAV2;TNW;PRKCBB;LAMB1A;LAMC2;ROCK2;TNR;CAPN2
Signaling pathways regulating pluripotency of stem cellsPIK3R1;MAPK11;GRB2;SMARCAD1;WNT2;REST;INHBB;FZD2;ACVR2A
Platelet activationPIK3CB;PIK3CA;MAPK3;PLCB1;PLCB4;PLCB2;PLA2G4F;PLA2G4A;RAP1B
Toll-like receptor signaling pathwayTRAF3;MAPK3;IFNA8;CD80;LY96;MAP2K4;IFNA2;RAC1A;IFNA16
Jak-STAT signaling pathwayIL19;IL2RG;IL9R;EPO;IL23;CSH1;IL12A;EP300;Gh
Natural killer cell mediated cytotoxicityFasl;SHC3;KIR2DL1;SH2D1B;FYN;Raet1a;BID;KLRC2;SH2D1A
T cell receptor signaling pathwayMAPK12;PPP3CB;MAP2K7;HRAS;NFATC3;GSK3B;PPP3CA;PDPK1;NFKB1
B cell receptor signaling pathwayPIK3R3;CMTM3;CRKL;LILRB3;FOS;NRAS;DAPP1;RAC2;PILRB
Fc epsilon RI signaling pathwayRAC3;FYN;PIK3R2;SYK;PLA2G4C;IL3;PIK3R5;HRAS;PLA2G4F
Fc gamma R-mediated phagocytosisPRKCD;SCIN;SPHK1;PLA2G4F;ARF6;PIK3R5;VAV1;RAF1;PLA2G6
TNF signaling pathwayTAB2;BIRC2;CREB5;RELA;CXCL1;MLKL;PIK3CD;IL18R1;LTA
Leukocyte transendothelial migrationMAPK12;VASP;CLDN22;MYL12A;NIPAL1;ACTN3;RAP1A;ACTB;PLCG1
Neurotrophin signaling pathwayCALM4;TP73;KRAS;SH2B3;SOS1;CALM2;ARHGDIB;BRAF;PIK3R1
Cholinergic synapseCREB3;GNGT1;CHRNA6;PIK3CB;GNG4;KCNQ5;PRKACA;PLCB3;KCNJ6
Inflammatory mediator regulation of TRP channelsIL1RAP;PRKCB;HTR2B;PIK3CD;MAPK9;CYP2C50;ALOX12E;PLCB3;CYP4A10
Regulation of actin cytoskeletonVAV2;PIP5K1AB;MYL10;CYFIP2;CDC42L2;SLC9A1;PTK2AB;MYLPF;FGF7
Insulin signaling pathwayPPP1R3A;INPPL1A;RPS6;ARAF;PDE3B;EIF4E1C;RAF1B;PCK1;CBLC
Progesterone-mediated oocyte maturationRPS6KA1;IGF1RB;CCNA1;MAPK9;MAD2L1;ANAPC7;CPEB1B;FZR1;CCNA2
Estrogen signaling pathwayCREB3L3;SHC4;PLCB4;HSPA2;OPRM1;SP1;PIK3CA;GPR30;HSP90B1
Prolactin signaling pathwayFOS;STAT5B;PIK3R2;STAT3;GALT;SLC2A2;ESR2;INS;MAPK10
Thyroid hormone signaling pathwayNOTCH2;FXYD2;SRC;MED4;STAT1;CCND1;MED30;PRKACA;PIK3R5
Oxytocin signaling pathwayPLA2G4D;MYLK2;RCAN1;NPR1;NFATC1;MYLK4;RYR1;ELK1;CAMK2B
Regulation of lipolysis in adipocytesPIK3CA;IRS2;IRS1;PRKG2;INS;LIPE;PRKACA;PIK3R5;PTGS2
Type II diabetes mellitusINS-IGF2;PDX1;TNF;INS1;IKBKB;IRS4;PKM2;INSR;MTOR
Insulin resistancePRKAA1;PRKAB1A;TBC1D4;PPP1R3CA;PTENA;PPP1CBL;SLC2A1A;PRKAG1;SLC2A4
Non-alcoholic fatty liver disease (NAFLD)NDUFA5;NDUFA4L2;DDIT3;NDUFB7;NDUFB9;RXRA;UQCRC2;UQCRH;COX5A
Aldosterone-regulated sodium reabsorptionINS;PDPK1;PIK3R3;HSD11B2;PIK3R5;MAPK3;IRS1;SFN;PIK3CD
Carbohydrate digestion and absorptionAMY2A4;PIK3CA;AKT1;TAS1R2;PLCB2;ATP1A2;AMY1B;HK3;ATP1B2
Bacterial invasion of epithelial cellsCBLC;PIK3CA;CRK;ARPC1B;SEPT12;PIK3R5;PIK3CB;PIK3CG;PIK3CD
Chagas disease (American trypanosomiasis)TLR9;CD3D;GNAO1;IL10;TGFB2;TGFBR2;PIK3CG;MAPK13;IL-8
ToxoplasmosisAKT1;HLA-DMB;STAT3;HSPA6;HLA-DRB1;LAMA1;PIK3R5;LAMC2;HLA-DPB1
AmoebiasisC8A;GM-CSF;HSPB1;PRKACA;LAMB3;LAMC3;NOS2;COL27A1;COL4A6
Hepatitis CIFNA8;PIK3R2;NR1H3;PIK3CB;TLR3;IFNA14;STAT2;OAS1;CLDN22
Hepatitis BIFNA16;NRAS;IKBKG;PIK3CG;CCNE1;PRKCB;STAT5A;CXCL8;PCNA
MeaslesTYK2;PIK3CA;EIF2AK2;MSN;CCNE1;IFNA12;RAB9B;HSPA2;CD28
Influenza AIFNA16;BLB1;RAE1;BLA;RAF1;TNFRSF10C;PIK3R1;PIK3CB;EP300
HTLV-I infectionPOLE4;HLA-DMB;PIK3R2;PIK3R1;TLN1;VDAC3;MSX2;VCAM1;WNT1
Epstein-Barr virus infectionPOLR2F;POLR3H;HLA-C;HLA-DRB1;POLR2J3;CCNA2;NFKB1;CD40;FCER2
Pathways in cancerFlt3l;PLCG1;SMAD4;TFG;LAMB2;WNT5A;STAT3;GNB3;GLI2
Viral carcinogenesisTRAF2;STAT3;PIK3R1;DNAJA3;HIST1H4E;UBR4;SCRIB;MAPK3;HIST1H4B
Proteoglycans in cancerFZD6;PIK3CA;RAC1;FZD5;TLR2;ITGB5;IGF1R;ITPR1;HIF1A
Colorectal cancerPIK3CB;PIK3R2;PIK3CD;DCC;APC2;SMAD2;GSK3B;AXIN2;RAC3
Renal cell carcinomaKRAS;MAPK1;PTPN11;GAB1;PIK3R1;PAK3;MET;RAPGEF1;EP300
Pancreatic cancerTRP53;BAD;IKBKB;KRAS;MAPK9;SMAD3;TGFB3;STAT3;RELA
Endometrial cancerAXIN2;CDH1;PTEN;HRAS;PIK3CB;PIK3R3;GSK3B;AKT1;KRAS
GliomaCALM2;PRKCG;PIK3R3;SHC2;CAMK2G;PIK3CB;PDGFA;PTEN;PIK3CA
Prostate cancerCCND1;BCL2;FOXO1;NKX3;GRB2;ATF4;SRD5A2;BAD;PIK3R1
MelanomaPIK3CB;FGF2;FGF13;FGF8;AKT2;IGF1;PIK3R5;BRAF;PIK3CG
Chronic myeloid leukemiaNFKBIA;STAT5B;MDM2;RELA;PIK3R1;KRAS;TGFB2;CDK6;TRP53
Acute myeloid leukemiaSTAT5B;MAP2K2;PIK3R2;RAF1;AKT3;RARA;PIK3CD;SOS1;PIM1
Small cell lung cancerLAMC1;PIK3R5;BIRC8;PIK3R1;PTEN;NFKB1;RARB;PIAS2;PIK3R2
Non-small cell lung cancerPIK3R2;ERBB2;PIK3CG;KRAS;PDPK1;RAF1;FHIT;GRB2;CCND1
Central carbon metabolism in cancerPIK3R2;SLC2A1;PIK3R3;HK1;PDK1;NTRK1;TP53;PDHA2;ERBB2
Choline metabolism in cancerPIK3CB;MAP2K1;DGKB;DGKZ;PCYT1A;WASF2;PPAP2C;FOS;EIF4EBP1

PIK3R3 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R3 itself. We selected most functions PIK3R3 had, and list some proteins which have the same functions with PIK3R3. You can find most of the proteins on our site.

Function Related Protein
1-phosphatidylinositol-3-kinase activityPIK3C3;PIK3R3;PIK3CA;PIK3CG;PIK3C2A;PIK3C2B;PIK3C2G;PIK3CB;PIK3CD
1-phosphatidylinositol-3-kinase regulator activityCCKBR;PIK3R1;PIK3R3A;PIK3R3B;PIK3R5;PIK3R3;PIK3R6;PIK3R2
protein bindingTRIM16;ARNT;CCDC112;ZNF335;EFTUD2;ALKBH8;PPP2R3A;SCRN1;CCL5

PIK3R3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R3.

EGFR; PIK3CA; PTK2; SRC; CRK; PLEKHS1

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