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PLEKHG4

Official Full Name

pleckstrin homology domain containing, family G (with RhoGef domain) member 4
Overview

The protein encoded by this gene contains multiple domains suggestive of a role in intracellular signaling and cytoskeleton dynamics at the Golgi apparatus. Mutations in this gene are associated with spinocerebellar ataxia 16q22-linked. Several alternatively spliced transcript variants, differing only in the 5 UTR, or encoding a different isoform, have been found for this gene.
Synonyms

PLEKHG4; pleckstrin homology domain containing, family G (with RhoGef domain) member 4; SCA4, spinocerebellar ataxia 4; puratrophin-1; ARHGEF44; DKFZP434I216; puratrophin 1; Pleckstrin homology domain containing family G (with RhoGef domain) member 4; Pleckstrin homology domain containing family G member 4; PLEKHG 4; PRTPHN 1; PRTPHN1; Puratrophin1; Purkinje cell atrophy associated protein 1; SCA 4; SCA4; PH domain-containing family G member 4; Purkinje cell atrophy-associated protein 1; pleckstrin homology domain-containing family G member 4;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PLEKHG4-1376HCL	Recombinant Human PLEKHG4 cell lysate		N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein

PLEKHG4 involved in several pathways and played different roles in them. We selected most pathways PLEKHG4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PLEKHG4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PLEKHG4 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLEKHG4 itself. We selected most functions PLEKHG4 had, and list some proteins which have the same functions with PLEKHG4. You can find most of the proteins on our site.

Function	Related Protein
Rho guanyl-nucleotide exchange factor activity	ARHGEF1;ITSN2A;ABR;RASGRF2;PLEKHG6;PLEKHG2;ARHGEF6;ARHGEF1A;FGD4
protein binding	HSP90AA1.2;CPT1B;NEDD9;CSRNP2;SYK;RRM2;NUPL1;CCDC70;C1orf105

PLEKHG4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLEKHG4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLEKHG4.

MDFI; COIL; q9wmx2-pro_0000037548