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POLD1

Official Full Name

polymerase (DNA directed), delta 1, catalytic subunit 125kDa
Overview

This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase;and 3 to 5 exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced;transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of;chromosome 6.
Synonyms

POLD1; polymerase (DNA directed), delta 1, catalytic subunit 125kDa; POLD, polymerase (DNA directed), delta 1, catalytic subunit (125kD); DNA polymerase delta catalytic subunit; CDC2; CDC2 homolog (S. cerevisiae); CDC2 homolog; DNA polymerase subunit del;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
His|GST
N/A
N
GST

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	POLD1-28360TH	Recombinant Human POLD1, His-tagged	E.coli	His		Inquiry
Human	POLD1-8025H	Recombinant Human POLD1 protein, His & GST-tagged	E.coli	His/GST	Met41~Phe254 (Accession # P28340)	Inquiry
Human	POLD1-3053HCL	Recombinant Human POLD1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	POLD1-4951H	Recombinant Human POLD1 Protein (Met41-Phe254), N-GST tagged	E.coli	N-GST	Met41-Phe254	Inquiry
Mouse	POLD1-13068M	Recombinant Mouse POLD1 Protein	Mammalian Cell	His		Inquiry
Mouse	Pold1-1958M	Recombinant Mouse Pold1 Protein, His-tagged	E.coli	N-His	Ser29-Gly260	Inquiry
Mouse	POLD1-6904M	Recombinant Mouse POLD1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	POLD1-6904M-B	Recombinant Mouse POLD1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	POLD1-4562R	Recombinant Rat POLD1 Protein	Mammalian Cell	His		Inquiry
Rat	POLD1-4222R-B	Recombinant Rat POLD1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	POLD1-4222R	Recombinant Rat POLD1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	POLD1-3654Z	Recombinant Zebrafish POLD1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

POLD1 involved in several pathways and played different roles in them. We selected most pathways POLD1 participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Purine metabolism	PPAT;PGM2;PKMA;PDE4D;NT5C3B;PDE4C;PAPSS2;AMPD3;PDE6G
Pyrimidine metabolism	POLE2;ENTPD3;ENTPD1;NME1-NME2;NT5E;POLR2EB;POLR3GLB;UPB1;UCK2
Metabolic pathways	ATP6V1AA;OGDHA;APIP;SPTLC1;TPH1B;ALG13;DHRS9;CYP2C54;UGT1A2
DNA replication	POLE2;MCM3L;MCM6;POLE3;GINS1;GINS4;GMNN;GINS2;DBF4
Base excision repair	POLE3;xthA;mutY;UNGA;MUTYH;LIG1;APEX2;PARP3;TDG
Nucleotide excision repair	XPA;GPS1;CHD1L;NFRKB;POLD4;POLE4;INO80C;INO80B;RBX1
Mismatch repair	RPA3;EXO1;MLH3;RFC1;MSH6;RPA4;PMS2;POLD1;RPA2
Homologous recombination	RAD52;BRCA2;RAD51L3;EME1;RPA4;SSBP1;TOP3B;CDK5R2;POLD1
HTLV-I infection	HLA-E;IL2RG;MAP3K1;NRAS;WNT3A;XBP1;VDAC3;PCNA;MAP2K4

POLD1 has several biochemical functions, for example, 3-5-exodeoxyribonuclease activity, 4 iron, 4 sulfur cluster binding, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLD1 itself. We selected most functions POLD1 had, and list some proteins which have the same functions with POLD1. You can find most of the proteins on our site.

Function	Related Protein
3-5-exodeoxyribonuclease activity	TREX2;TREX1;POLD1
4 iron, 4 sulfur cluster binding	NDUFS1;NFU1;NTHL1;ISCUB;PRIM2;NDUFS2;BRIP1;SDHB;ISCA1
DNA binding	TRERF1;ZNF434;TRIM28;HIST2H2AA4;TFCP2;RAD54B;ADAR;TMF1;CENPW
DNA-directed DNA polymerase activity	MYBBP1A;POLK;POLG2;POLG;POLH;PRIMPOL;POLA2;DNTT;POLE3
chromatin binding	ATF2;TP53;PHC1;MORF4L1;SKIL;PPARG;GATA6;PRKCBB;KIAA0101
damaged DNA binding	PNKP;RAD1;POLI;RPA3;RAD23AA;RAD23B;TDG;UNG;TP53BP1
metal ion binding	PRIM1;Trf;ZFP710;ZNF207A;PRDM16;RNF149;CALUB;AGFG1B;GALNTL6
nucleotide binding	RBM19;ATP8B5;SEPT8A;ARL15A;DCLK1A;MAT2AB;UCKL1A;PABPN1L;LEMD3
protein binding	MCM6;CUL9;DNTTIP1;ATP2A1;EEF1B2;RNF126;FER;PPP2R5C;IFI30

POLD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLD1.

POLD4; POLD2