Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

POLD2

  • Official Full Name

    polymerase (DNA directed), delta 2, regulatory subunit 50kDa

  • Overview

    This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase;and 3 to 5 exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is;required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear;antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript;variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the;long arm of chromosome 5.
  • Synonyms

    POLD2; polymerase (DNA directed), delta 2, regulatory subunit 50kDa; polymerase (DNA directed), delta 2, regulatory subunit (50kD); DNA polymerase delta subunit 2; DNA polymerase delta subunit p50; DNA polymerase subunit delta 2; DNA polymerase subunit delta p50; DPOD2_HUMAN; POLD 2; OTTHUMP00000159252; OTTHUMP00000209249; OTTHUMP00000209250;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human POLD2-28358TH Recombinant Human POLD2 Wheat Germ N/A 469 amino acids
Human POLD2-1828H Recombinant Human POLD2, GST-tagged E.coli GST 245-430aa
Human POLD2-111H Recombinant Human POLD2 Protein, His-tagged E.coli His
Human POLD2-3052HCL Recombinant Human POLD2 293 Cell Lysate HEK293 N/A
Human POLD2-6587H Recombinant Human POLD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human POLD2-4964H Recombinant Human POLD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human POLD2-3277H Recombinant Human POLD2 protein, His-tagged E.coli His 245-430 aa
Human POLD2-2142H Recombinant Human POLD2 Protein (Met1-Pro469), C-His tagged E.coli C-His Met1-Pro469
Human POLD2-382HF Recombinant Full Length Human POLD2 Protein In Vitro Cell Free System 469 amino acids
Mouse POLD2-13069M Recombinant Mouse POLD2 Protein Mammalian Cell His
Mouse POLD2-6905M Recombinant Mouse POLD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pold2-4983M Recombinant Mouse Pold2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse POLD2-6905M-B Recombinant Mouse POLD2 Protein Pre-coupled Magnetic Beads HEK293
Rat POLD2-4563R Recombinant Rat POLD2 Protein Mammalian Cell His
Rat POLD2-4223R Recombinant Rat POLD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat POLD2-4223R-B Recombinant Rat POLD2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque POLD2-3504R Recombinant Rhesus monkey POLD2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque POLD2-3322R Recombinant Rhesus Macaque POLD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque POLD2-3322R-B Recombinant Rhesus Macaque POLD2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish POLD2-12491Z Recombinant Zebrafish POLD2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • POLD2 Related Articles

POLD2 involved in several pathways and played different roles in them. We selected most pathways POLD2 participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismAPRT;ENTPD6;PDE1A;POLR3B;ADKA;NME1;NUDT9;ENTPD2;URAH
Pyrimidine metabolismDPYS;NT5M;NT5C3B;CANT1A;NT5C2B;NME2B.2;PRIM2;UPB1;DCK
Metabolic pathwaysPCYT1BB;MOGAT3;SPHK2;PCYT1A;HSD17B8;CBR1;B4GALT1;PRODH;POLR2G
DNA replicationMCM7;RFC5;DBF4;LIG1;MCM2;MCM6L;MCM6;RPA1;RNASEH2A
Base excision repairPOLD1;mutY;FEN1;SMUG1;POLE4;NEIL3;MUTYH;HMGB1A;NTHL1
Nucleotide excision repairPPIE;COPS8;INO80C;RAD23AB;GTF2H3;GTF2H2C_2;RAD23A;PCNA;CUL4B
Mismatch repairRPA3;MSH3;EXO1;MSH2;RFC2;RFC3;SSBP1;MLH1;POLD4
Homologous recombinationRAD52;FUZ;RAD51D;CDK5R2;POLD4;RAD54L;RAD51B;NBN;RPA4
HTLV-I infectionPIK3R2;WNT5B;TP53;TGFB1;PIK3CD;WNT10B;HLA-DMB;FZD2;KAT2B

POLD2 has several biochemical functions, for example, DNA binding, DNA-directed DNA polymerase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLD2 itself. We selected most functions POLD2 had, and list some proteins which have the same functions with POLD2. You can find most of the proteins on our site.

Function Related Protein
DNA bindingNFYA;TMF1;MSXC;NKX6.1;PBX1B;ZNF350;SAP30;TCEANC2;TFEC
DNA-directed DNA polymerase activityDNTT;POLL;POLH;POLA2;POLG;POLD3;CCDC111;MYBBP1A;POLK
protein bindingANKS1A;MAP2K2;MAPRE3;FCER1G;MEIS1B;TA;DYNC1LI1;UBA1;BMPR1A

POLD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLD2.

POLD1; POLD3; PCNA; POLD4

Lee, MO; Yang, E; et al. Mapping and genotypic analysis of the NK-lysin gene in chicken. GENETICS SELECTION EVOLUTION 46:-(2014).
Lee, YS; Gregory, MT; et al. Human Pol zeta purified with accessory subunits is active in translesion DNA synthesis and complements Pol. in cisplatin bypass. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:2954-2959(2014).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All POLD2 Products

Required fields are marked with *

My Review for All POLD2 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends