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POLE2

Official Full Name

polymerase (DNA directed), epsilon 2 (p59 subunit)
Overview

DNA polymerase epsilon subunit 2?is an?enzyme?that in humans is encoded by the?POLE2?gene.
Synonyms

POLE2; polymerase (DNA directed), epsilon 2 (p59 subunit); DNA polymerase epsilon subunit 2; DPE2; DNA polymerase II subunit 2; DNA polymerase epsilon subunit B;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
Myc|DDK

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	POLE2-2454H	Recombinant Human POLE2 Protein, MYC/DDK-tagged	HEK293	Myc/DDK	Inquiry
Human	POLE2-2637H	Recombinant Human POLE2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Mouse	POLE2-13075M	Recombinant Mouse POLE2 Protein	Mammalian Cell	His	Inquiry
Mouse	POLE2-6907M-B	Recombinant Mouse POLE2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	POLE2-6907M	Recombinant Mouse POLE2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Zebrafish	POLE2-9520Z	Recombinant Zebrafish POLE2	Mammalian Cell	His	Inquiry
Chicken	POLE2-1632C	Recombinant Chicken POLE2	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
POLE2 Related Articles

POLE2 involved in several pathways and played different roles in them. We selected most pathways POLE2 participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Purine metabolism	PRPS1L1;PRIM1;NTPCR;CECR1A;RRM2;GUCY2C;PFAS;PGM2;POLR3A
Pyrimidine metabolism	NT5C1B-RDH14;NME7;POLR1B;NT5M;TXNRD3;POLR1C;POLR2B;POLE3;NME2A
Metabolic pathways	PAFAH1B1B;PIP5K1C;POLR2EB;CKMT2;ybaS;FBP1;UGT1A7;NT5C2A;LDHAL6B
DNA replication	GMNN;PRIM1;GINS4;DBF4;RFC5;RPA3;RFC2;POLE4;POLE2
Base excision repair	TDG;TDG.1;POLL;POLE2;APEX1;HMGB1B;PARP4;POLE4;PARP2
Nucleotide excision repair	CUL4A;RAD23AB;ERCC8;INO80B;INO80E;ZNF830;CUL4B;RFC3;COPS6
HTLV-I infection	GSK3B;HLA-DRB5;NFYB;PTTG2;POLD1;WNT6;CD3D;FZD8;TLN1

POLE2 has several biochemical functions, for example, DNA binding, contributes_to DNA-directed DNA polymerase activity, nucleotidyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLE2 itself. We selected most functions POLE2 had, and list some proteins which have the same functions with POLE2. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ZFP536;HOXA11B;ISL2;PROX1;MCM3AP;HOXB2;POU2F1B;H2AFB3;TFEC
contributes_to DNA-directed DNA polymerase activity
nucleotidyltransferase activity	POLR3B;MOCS3;CCDC111;PAPSS2;TAMM41;GMPPA;GMPPAB;POLR2B;TERT
transferase activity	TNK2B;PRKAR2AA;PRKG1A;UGT5E1;HS3ST3B1B;KDRL;UGT1B3;CEPT1B;GMPPAB

POLE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLE2.

Chao, YH; Wu, KH; et al. Downregulated CXCL12 expression in mesenchymal stem cells associated with severe aplastic anemia in children. ANNALS OF HEMATOLOGY 94:13-22(2015).

Liu, D; Zhang, XX; et al. Sine oculis homeobox homolog 1 promotes DNA replication and cell proliferation in cervical cancer. INTERNATIONAL JOURNAL OF ONCOLOGY 45:1232-1240(2014).