Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

POLR3A

Official Full Name

polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
Overview

The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response.
Synonyms

POLR3A; polymerase (RNA) III (DNA directed) polypeptide A, 155kDa; DNA-directed RNA polymerase III subunit RPC1; hRPC155; RPC1; RPC155; RNA polymerase III subunit C1; RNA polymerase III subunit C160; RNA polymerase III 155 kDa subunit; RNA polymerase III;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	POLR3A-730H	Recombinant Human POLR3A Protein (392-632 aa), His-SUMO-tagged	E.coli	His/SUMO	392-632 aa	Inquiry
Zebrafish	POLR3A-8286Z	Recombinant Zebrafish POLR3A	Mammalian Cell	His		Inquiry
Chicken	POLR3A-1639C	Recombinant Chicken POLR3A	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

POLR3A involved in several pathways and played different roles in them. We selected most pathways POLR3A participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Purine metabolism	ADK;NT5M;AK2;ADKB;POLD4;ATIC;ENTPD2;TM9SF1;PDE8B
Pyrimidine metabolism	NT5M;POLR2A;NME2;DCK;PNP5A;NME4;POLR1D;UPP2;NME2A
Metabolic pathways	TYR;DNMT4;DTYMK;AK7B;AGXT2;QDPRA;PLA2G4C;CBR3;PIGV
RNA polymerase	POLR2G;ZNRD1;POLR2J3;POLR2J2;POLR2GL;POLR3D;POLR2EB;POLR1C;POLR1D
Cytosolic DNA-sensing pathway	IFI202B;IFNA17;RELA;RIPK1L;IFNA8;Ifna11;RIPK1;POLR1C;IFNA4

POLR3A has several biochemical functions, for example, DNA binding, DNA-directed RNA polymerase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR3A itself. We selected most functions POLR3A had, and list some proteins which have the same functions with POLR3A. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ZNF490;RABGAP1;ZFAT;HMGXB3;ORC6L;ZNF576;IFIH1;KDM2BA;MYCL1
DNA-directed RNA polymerase activity	POLRMT;POLR2EB;POLR2I;CD3EAP;CCDC111;MED21;POLR3G;POLR2GL;POLR2M
metal ion binding	ITGAX;RUFY4;DPH3;ZNF295;SALL3;ANKIB1;RRM2B;RXRBB;PRKCDA

POLR3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR3A here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR3A.