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PPAP2A

Official Full Name

phosphatidic acid phosphatase type 2A
Overview

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. The expression of this gene is found to be regulated by androgen in a prostatic adenocarcinoma cell line. At least two alternatively spliced transcript variants encoding distinct isoforms have been described.
Synonyms

PPAP2A; phosphatidic acid phosphatase type 2A; lipid phosphate phosphohydrolase 1; LPP1; PAP 2a; Lipid phosphate phosphohydrolase 1a; LLP1a; PAP2; PAP2a2; PAP2alpha2; PAPalpha1; Phosphatidic acid phosphatase 2a; Phosphatidic acid phosphohydrolase type 2a; Type 2 phosphatidic acid phosphatase alpha; Type 2 phosphatidic acid phosphohydrolase; PAP2a; PAP2-alpha; phosphatidate phosphohydrolase type 2a; type-2 phosphatidic acid phosphatase alpha; PAP-2a;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	PPAP2A-2992HCL	Recombinant Human PPAP2A 293 Cell Lysate	HEK293	N/A	Inquiry
Mouse	PPAP2A-13154M	Recombinant Mouse PPAP2A Protein	Mammalian Cell	His	Inquiry
Mouse	PPAP2A-6963M	Recombinant Mouse PPAP2A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	PPAP2A-6963M-B	Recombinant Mouse PPAP2A Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein

PPAP2A involved in several pathways and played different roles in them. We selected most pathways PPAP2A participated on our site, such as Glycerolipid metabolism, Glycerophospholipid metabolism, Ether lipid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPAP2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glycerolipid metabolism	MOGAT3A;ALDH2.1;MOGAT2;DGKB;MBOAT1;LIPG;AKR1B1;GPAT2;LPIN2
Glycerophospholipid metabolism	LPCAT2;PLA2G4C;AGPAT5;AGXT2L1;CHKA;PLD1;PLD3;LPIN2;EPT1
Ether lipid metabolism	PPAP2C;TMEM86B;PLA2G7;CEPT1;PAFAH1B1A;PLA2G2A;PLA2G5;PAFAH2;PLA2G4F
Sphingolipid metabolism	LASS1;PPAP2D;ARSF;ARSH;GLB1;SPTLC2A;CERS2;SPTLC1;DEGS2
Metabolic pathways	PDXKB;PTDSS2;ATP6V1B2;HK2;ALG10B;MAT1A;Ckmm;GALE;PHYKPL
Phospholipase D signaling pathway	RALGDS;PLD2;PIP5K1B;RHEB;PTK2B;PLA2G4F;PIK3R3;AVP;PIP5K1C
Fc gamma R-mediated phagocytosis	PRKCG;WASF2;MAPK3;PIK3CD;CDC42;BIN1;PIK3CB;VAV3;PPAP2B
Fat digestion and absorption	PLA2G12B;PNLIPRP1;SLC27A4;CLPS;FABP2;LIPF;AGPAT1;DGAT2;PPAP2A
Choline metabolism in cancer	WASF1;PIK3R5;KRAS;RPS6KB1;AKT1;WASF3;PDGFA;RAF1;PLA2G4B

PPAP2A has several biochemical functions, for example, lipid phosphatase activity, phosphatidate phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPAP2A itself. We selected most functions PPAP2A had, and list some proteins which have the same functions with PPAP2A. You can find most of the proteins on our site.

Function	Related Protein
lipid phosphatase activity	LPPR3A;PPAP2C;LPPR3;LPPR5B;EPHX2;PPAP2CB;LPPR5A;INPP5K;PPAP2A
phosphatidate phosphatase activity	PPAP2CB;LPPR3;LPPR2;PPAPDC1A;LPIN1;PPAPDC1B;STIL;PPAP2A;PPAP2C

PPAP2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPAP2A here. Most of them are supplied by our site. Hope this information will be useful for your research of PPAP2A.

CREB3; FAHD1; yapB