PPARGC1A
-
Official Full Name
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
-
Overview
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. -
Synonyms
PPARGC1A; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; peroxisome proliferative activated receptor, gamma, coactivator 1 , peroxisome proliferative activated receptor, gamma, coactivator 1, alpha , PPARGC1; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC1; PGC1A; LEM6; Ligand effect modulator 6; Peroxisome proliferative activated receptor gamma coactivator 1 alpha; Peroxisome proliferative activated receptor gamma coactivator 1; Peroxisome proliferator activated receptor gamma coactivator 1 alpha; PGC 1 (alpha); PGC 1 alpha; PGC 1v; PGC-1-alpha; PGC1(alpha); PGC1v; PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6; PPAR gamma coactivator 1 alpha; PPAR gamma coactivator 1; PPAR gamma coactivator 1-alpha; PPAR gamma coactivator variant form; PPAR-gamma coactivator 1-alpha; PPARGC 1 alpha; PPARGC-1-alpha; PPARGC1; PRGC1_HUMAN; OTTHUMP00000123372; ligand effect modulator-6; PGC-1v; PGC-1(alpha);
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | PPARGC1A-729H | Recombinant Human PPARGC1A Protein, His-tagged | E.coli | His | Ser573~Asn767 | |
Human | PPARGC1A-8291H | Recombinant Human PPARGC1A protein, GST-tagged | Wheat Germ | GST | ||
Human | PPARGC1A-2611H | Recombinant Human PPARGC1A Protein, His-tagged | E.coli | N-His | Glu350-Arg798 | |
Mouse | Ppargc1a-8492M | Recombinant Mouse Ppargc1a protein, His-tagged | E.coli | His | ||
Mouse | PPARGC1A-13163M | Recombinant Mouse PPARGC1A Protein | Mammalian Cell | His | ||
Mouse | Ppargc1a-1962M | Recombinant Mouse Ppargc1a Protein, His-tagged | E.coli | N-His | Glu349-Arg797 | |
Mouse | PPARGC1A-6970M | Recombinant Mouse PPARGC1A Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | PPARGC1A-6970M-B | Recombinant Mouse PPARGC1A Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | PPARGC1A-4594R | Recombinant Rat Ppargc1a protein, His-tagged | E.coli | His | Ser588~Ser773 | |
Rat | PPARgC1a-1248R | Recombinant Rat PPARgC1a protein, His-tagged | E.coli | His | Glu348~Arg796 |
- Involved Pathway
- Protein Function
- Interacting Protein
- PPARGC1A Related Research Area
PPARGC1A involved in several pathways and played different roles in them. We selected most pathways PPARGC1A participated on our site, such as AMPK signaling pathway, Insulin signaling pathway, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPARGC1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
AMPK signaling pathway | FBP1;G6PC3;CREB3L2;PRKAG3;G6PC;PIK3R5;RAB8A;PPARGC1A;PIK3CA |
Insulin signaling pathway | SHC1;PIK3R3B;GRB2;FASN;PRKAG3;RAF1;PYGMA;PRKAA2;EIF4E2 |
Adipocytokine signaling pathway | NPY;POMC;STAT3;ACACB;TNF;ACSBG1;G6PC;ACSL4A;PTPN11A |
Insulin resistance | GSK3AA;FOXO1A;TNFRSF1A;SOCS3B;SLC27A1B;TBC1D4;RPS6KB1B;GFPT1;PIK3R3 |
Huntingtons disease | SP1;NDUFC2-KCTD14;POLR2K;NDUFA3;COX4I1;POLR2C;CASP9;NDUFS6;UQCRFS1 |
PPARGC1A has several biochemical functions, for example, DNA binding, RNA binding, RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPARGC1A itself. We selected most functions PPARGC1A had, and list some proteins which have the same functions with PPARGC1A. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
DNA binding | ZNF593;EVX2;VPS72;OTX1B;ATF4;ZEB1B;TRIM30A;RFX5;GM239 |
RNA binding | RBM18;RPL30;PSMA1;U2SURP;RBFOX1;RTCA;ILF3B;RPL13;SRSF3 |
RNA polymerase II transcription cofactor activity | MED22;MED18;MED13;PPARGC1B;NKX2-5;TDG;MED19B;MED7;TP53BP1 |
alpha-tubulin binding | SLC6A2;DDL-2;PACRG;SERPINB1A;ARL8B;WASH1;HDAC6;FAM110C;BBS4 |
chromatin DNA binding | PPARGC1A;RARA;EZH2;BCL6;MED1;XBP1;H2AFY2;VAX1;SLAMF7 |
chromatin binding | MITF;CBX1;CREB3L1;EP300;NR5A2;PRKAA2;TLE4;TCF7L2;REL |
estrogen receptor binding | XBP1;NKX3-1;LEF1;PPARGC1B;PPARG;STRN;DDX5;WIPI1;ISL1 |
ligand-dependent nuclear receptor binding | JUND;ISL1;NCOA1;NCOR1;TADA3;NCOA2;NCOR2;TRIP4;C1D |
ligand-dependent nuclear receptor transcription coactivator activity | TADA3;PKN1;RBM14;PPRC1;MED24;PPARGC1B;ENY2;BUD31;HMGA1-RS1 |
nucleic acid binding | NPM2A;PRDM13;METTL5;ZIC6;DHX57;SRSF5B;ZCCHC18;ZFP276;RBM4.1 |
nucleotide binding | RBM5;SR140;JAK2A;OXSR1B;ABCA4;NLRP4C;PABPC1B;KIF5AA;TUBA8L |
peroxisome proliferator activated receptor binding | PRMT2;IKBKG;NFATC4;MED1;EP300;ASXL2;HMGA1;CREBBP;PPARGC1A |
promoter-specific chromatin binding | |
protein binding | PAPD4;HNRNPH1;PAX9;CDK18;SCYL3;DCAF11;ARAP1;NDUFB11;BAIAP2L1 |
sequence-specific DNA binding | FOXR1;ARNTL;ESRRB;TEFA;ZNF215;POU2F3;CREB3L1;HOXA5A;MSXB |
transcription coactivator activity | RAP2C;PIAS2;SUB1;CTBP2;JUND;HCFC1;JUP;YAF2;MAGED1 |
transcription factor binding | HDAC7;DRG1;NFATC2;TFAP2A;SIRT1;REST;HEYL;CAMTA2;TRP53 |
ubiquitin protein ligase binding | UBE2NB;GRIK2;PRKACB;RALB;HDAC6;UCHL1;RELA;CCDC50;SMAD5 |
PPARGC1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPARGC1A here. Most of them are supplied by our site. Hope this information will be useful for your research of PPARGC1A.
Sirt1; Irf4; Lrpprc; LRPPRC; IQGAP1; EP300; SIRT1; NR1I2
- Q&As
- Reviews
Q&As (7)
Ask a questionPPARGC1A is crucial for thermogenesis, particularly in brown adipose tissue, aiding in heat production.
Therapeutic strategies targeting PPARGC1A aim to modulate its activity to treat metabolic disorders and enhance mitochondrial function.
PPARGC1A is a master regulator of energy metabolism, coordinating various metabolic pathways.
PPARGC1A is highly expressed in tissues with high energy demands, such as muscles and brown adipose tissue.
Genetic variations in PPARGC1A have been associated with altered metabolic function and disease susceptibility.
Dysregulation of PPARGC1A is linked to metabolic disorders, including diabetes and obesity.
It stimulates mitochondrial biogenesis, enhancing cellular energy production.
Customer Reviews (3)
Write a reviewQuality product, worked well.
Very happy, will reorder.
Worked perfectly in tests.
Ask a Question for All PPARGC1A Products
Required fields are marked with *
My Review for All PPARGC1A Products
Required fields are marked with *