PPARGC1B
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Official Full Name
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
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Overview
The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PPARGC1B; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; peroxisome proliferative activated receptor, gamma, coactivator 1, beta; peroxisome proliferator-activated receptor gamma coactivator 1-beta; PERC; PGC1B; PPARGC-1-beta; PPAR-;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | PPARGC1B-1873H | Recombinant Human PPARGC1B, GST-tagged | E.coli | GST | 1-350aa | |
Human | PPARGC1B-2984HCL | Recombinant Human PPARGC1B 293 Cell Lysate | HEK293 | N/A | ||
Mouse | PPARGC1B-13164M | Recombinant Mouse PPARGC1B Protein | Mammalian Cell | His | ||
Mouse | PPARGC1B-6971M | Recombinant Mouse PPARGC1B Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | PPARGC1B-6971M-B | Recombinant Mouse PPARGC1B Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | PPARGC1B-4595R | Recombinant Rat PPARGC1B Protein | Mammalian Cell | His | ||
Rat | PPARGC1B-4254R | Recombinant Rat PPARGC1B Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | PPARGC1B-4254R-B | Recombinant Rat PPARGC1B Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
PPARGC1B involved in several pathways and played different roles in them. We selected most pathways PPARGC1B participated on our site, such as AMPK signaling, Energy Metabolism, Fatty acid, triacylglycerol, and ketone body metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPARGC1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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AMPK signaling | INS-IGF2;CPT1B;SLC2A4RG;PPARGC1B;CAMKK2;EIF4EBP1;CDKN1A;ADRA1B;EEF2 |
Energy Metabolism | MEF2B;MYBBP1A;TFB1M;TFB2M;ESRRA;PPARGC1B;UCP3;GABPA;UCP2 |
Fatty acid, triacylglycerol, and ketone body metabolism | MED15;MED25;ACOT11;ACOT13;SLC25A1A;CYP7A1;DECR1;ACOT11B;CDK19 |
Insulin resistance | PPP1R3D;SLC27A5;PPP1CB;MTOR;SLC2A2;G6PCA.2;SOCS3B;PTENA;NFKBIAA |
Metabolism | LMF1;SLC25A27;APOBB.1;GLYATL2;ACOT9.2;APOA4B.2;TPTE;MAPK1IP1L;PAICS |
Metabolism of lipids and lipoproteins | MTP;CERS5;ARSJ;MED9;SCP2B;BCHE;PMVK;SLC25A20;APOA4B.1 |
Mitochondrial Gene Expression | TFB1M;PPRC1;POLRMT;PPARGC1B;TFB2M;MTERFD1;ESRRA |
Mitochondrial biogenesis | TFB1M;C10orf2;POLRMT;GABPB1;ESRRA;GABPA;MTERF;PPRC1;PPARGC1B |
PPARGC1B has several biochemical functions, for example, AF-2 domain binding, RNA binding, RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPARGC1B itself. We selected most functions PPARGC1B had, and list some proteins which have the same functions with PPARGC1B. You can find most of the proteins on our site.
Function | Related Protein |
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AF-2 domain binding | PPARGC1B;ESRRG;NR0B1 |
RNA binding | C14orf166;EIF4E2RS1;PSMA1;RBM17;IFIT1;U2AF1L4;NCL;EIF4EB;DZIP3 |
RNA polymerase II transcription cofactor activity | PPARGC1B;MED19B;CNOT2;TDG;TP53BP1;MED30;PPRC1;MED8;MED19 |
estrogen receptor binding | TMEM38A;ARRB1;HSD17B10;NKX3-1;WIPI1;TAF10;DDX17;XBP1;TRIP4 |
ligand-dependent nuclear receptor transcription coactivator activity | ZMIZ2;PPARGC1B;KDM1A;ZCCHC12;ACTN4;RBM14;USP22;PPRC1;SMARCD3 |
nucleotide binding | ARL8;RBM24A;MAPKAPK2B;CDK12;CAMK2G1;DHX37;RBM39A;TARDBP;HNRNPC |
receptor activator activity | PRKCE;IGF2;PPARGC1B |
transcription factor binding | ZEB1;E2F5;E2F1;C1QBP;RELA;HDAC3;CDKN2A;NFATC2;JUND |
PPARGC1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPARGC1B here. Most of them are supplied by our site. Hope this information will be useful for your research of PPARGC1B.
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