PPIL2
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Official Full Name
peptidylprolyl isomerase (cyclophilin)-like 2
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Overview
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PPIL2; peptidylprolyl isomerase (cyclophilin)-like 2; peptidyl-prolyl cis-trans isomerase-like 2; Cyp 60; FLJ39930; CYC4; Cyclophilin 60; Cyclophilin 60kDa; Cyclophilin like protein Cyp 60; Cyclophilin-60; Cyclophilin-like protein Cyp-60; CYP60; hCyP 60; MGC33174; MGC787; Peptidyl prolyl cis trans isomerase like 2; Peptidylprolyl cis trans isomerase; Peptidylprolyl isomerase cyclophilin like 2; PPIase; PPIL2_HUMAN; Rotamase; Rotamase PPIL2; cyclophilin, 60kDa; peptidylprolyl cis-trans isomerase; Cyp-60; hCyP-60;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- N/A
- No tag
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | PPIL2-537H | Recombinant Human PPIL2 protein, His-tagged | E.coli | His | Gly280-Pro457 |
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| Human | PPIL2-1888H | Recombinant Human PPIL2, GST-tagged | E.coli | GST | C-term-300aa | |
| Human | PPIL2-2030H | Recombinant Human PPIL2, His-tagged | E.coli | His |
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| Human | PPIL2-2967HCL | Recombinant Human PPIL2 293 Cell Lysate | HEK293 | N/A |
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| Human | PPIL2-0509H | Recombinant Human PPIL2 Protein (G2-W520), Tag Free | E.coli | No tag | G2-W520 |
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| Human | PPIL2-0510H | Recombinant Human PPIL2 Protein (G2-W520), His tagged | E.coli | His | G2-W520 |
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| Mouse | PPIL2-13188M | Recombinant Mouse PPIL2 Protein | Mammalian Cell | His |
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| Mouse | PPIL2-6985M | Recombinant Mouse PPIL2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | PPIL2-6985M-B | Recombinant Mouse PPIL2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | PPIL2-11225Z | Recombinant Zebrafish PPIL2 | Mammalian Cell | His |
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| Chicken | PPIL2-2359C | Recombinant Chicken PPIL2 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- PPIL2 Related Articles
PPIL2 involved in several pathways and played different roles in them. We selected most pathways PPIL2 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPIL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | RBX1;ANAPC5;TRIP12;SKP2;UBE2NB;UBE2D1A;FLJ11011L;UBE2L3A;PIAS4B |
PPIL2 has several biochemical functions, for example, ligase activity, peptidyl-prolyl cis-trans isomerase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPIL2 itself. We selected most functions PPIL2 had, and list some proteins which have the same functions with PPIL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | RNF170;TRAF3;WWP1;UFL1;TRIM33;MARCH9;CBLL1;RNF4;RFWD2 |
| peptidyl-prolyl cis-trans isomerase activity | PPIL3;FKBP3;PPIL6;FKBP1AA;RANBP2;FKBP1B;PPIH;FKBPL;FKBP10 |
| protein binding | AZI2;PPP2R2B;PSMC4;SCAMP1;CHD1;SV2B;ITGAV;PAWR;TRPC2 |
| ubiquitin protein ligase activity | CBLL1;SYVN1;UHRF1;ANKIB1;UBE3A;CCNC;UBE2C;ANKIB1A;HLTF |
| ubiquitin-ubiquitin ligase activity | UBOX5;ANAPC11;UBE2K;RBX1;STUB1;UBE4B;PPIL2;AMFR;PRPF19 |
PPIL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPIL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPIL2.
TRIM23; ZNF830; KANSL2; PRCC; Naa15; PDGFRA; VPS26B; KLC3; Srsf1; Smad3; Ccdc12; KLC2; PIM2; BAIAP2; Racgap1
- Q&As
- Reviews
Q&As (5)
Ask a questionPotential side effects of targeting PPIL2 protein may include immune dysregulation, off-target effects, and interference with normal cellular functions.
PPIL2 protein interacts with a wide range of cellular proteins, influencing their stability and function, which can have implications for disease progression and treatment.
Therapeutic strategies include small molecule inhibitors targeting PPIL2 protein, as well as gene therapy approaches to modulate its expression.
Yes, PPIL2 protein has been shown to modulate the activity of immune cells and cytokine production, suggesting a potential role in regulating immune responses in diseases.
Some genetic variations in the PPIL2 gene have been linked to increased risk of certain autoimmune diseases and cancers.
Customer Reviews (3)
Write a reviewWith the PPIL2 protein at hand, I am excited to embark on my scientific journey with confidence and optimism.
I am confident that incorporating the PPIL2 protein into my research will yield accurate and reliable results, enabling deeper insights into cellular processes
Their expertise and guidance will undoubtedly prove valuable in overcoming hurdles and maximizing the potential of this protein in my research endeavors.
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