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PPM1F

Official Full Name

protein phosphatase, Mg2+/Mn2+ dependent, 1F
Overview

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.
Synonyms

PPM1F; protein phosphatase, Mg2+/Mn2+ dependent, 1F; protein phosphatase 1F (PP2C domain containing); protein phosphatase 1F; Ca(2+)/calmodulin dependent protein kinase phosphatase; CAMKP; CaMKPase; FEM 2; KIAA0015; partner of PIX 2; POPX2; PP2C phosphata;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PPM1F-31046TH	Recombinant Human PPM1F	E.coli	N/A		Inquiry
Human	PPM1F-1895H	Recombinant Human PPM1F, His-tagged	E.coli	His	104-453aa	$319 / 25ug
Human	PPM1F-2281H	Recombinant Human PPM1F, His-tagged	E.coli	His	477aa	Inquiry
Human	PPM1F-1439H	Recombinant Human PPM1F,GST-tagged	E.coli	GST		Inquiry
Human	PPM1F-2961HCL	Recombinant Human PPM1F 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	PPM1F-13199M	Recombinant Mouse PPM1F Protein	Mammalian Cell	His		Inquiry
Mouse	Ppm1f-5047M	Recombinant Mouse Ppm1f Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	PPM1F-6991M-B	Recombinant Mouse PPM1F Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	PPM1F-6991M	Recombinant Mouse PPM1F Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	PPM1F-2663Z	Recombinant Zebrafish PPM1F	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

PPM1F involved in several pathways and played different roles in them. We selected most pathways PPM1F participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PPM1F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PPM1F has several biochemical functions, for example, calmodulin-dependent protein phosphatase activity, metal ion binding, phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPM1F itself. We selected most functions PPM1F had, and list some proteins which have the same functions with PPM1F. You can find most of the proteins on our site.

Function	Related Protein
calmodulin-dependent protein phosphatase activity	PPM1F;PPP3CB;PPM1A;PPP3CA
metal ion binding	PPP5C;CLCA3;KEX2;ZNF556;PPARAA;RPAIN;ARFGAP3;FOXP1B;RAF1A
phosphatase activity	PHOSPHO1;C12orf5;DUSP13A;PTPN4A;CAR3;PPP1CC;MTMR1B;DUSP23B;CTDNEP1
protein binding	OPRK1;LRFN2;LDLRAD1;MAFG;TMUB2;SPRR2E;CAP2;CHRNB2;C8orf48
protein serine/threonine phosphatase activity	TAB1;PDP2;PPP1R15B;DULLARD;PDP1;PPM1AA;DUSP23A;PPM1F;PPP6C

PPM1F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPM1F here. Most of them are supplied by our site. Hope this information will be useful for your research of PPM1F.

DIAPH1; FEM1B; CAMK2A; Camkk2; MARS; FAM161A; PRKAA2; PRKAA1; PAK1; PAK2