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PPRC1

  • Official Full Name

    peroxisome proliferator-activated receptor gamma, coactivator-related 1

  • Overview

    The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
  • Synonyms

    PPRC1; peroxisome proliferator-activated receptor gamma, coactivator-related 1; PRC; peroxisome proliferator-activated receptor gamma coactivator-related protein 1; PGC-1-related coactivator;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse PPRC1-13280M Recombinant Mouse PPRC1 Protein Mammalian Cell His
Mouse PPRC1-7049M-B Recombinant Mouse PPRC1 Protein Pre-coupled Magnetic Beads HEK293
Mouse PPRC1-7049M Recombinant Mouse PPRC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PPRC1 involved in several pathways and played different roles in them. We selected most pathways PPRC1 participated on our site, such as Mitochondrial Gene Expression, Mitochondrial biogenesis, Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPRC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Mitochondrial Gene ExpressionTFB1M;PPARGC1B;TFB2M;ESRRA;PPRC1;MTERFD1;POLRMT
Mitochondrial biogenesisPOLG2;C10orf2;ESRRA;PPARGC1B;GABPB1;TFB1M;POLRMT;MTERF;GABPA
Organelle biogenesis and maintenanceTTBK2;TSFM;TFB2M;MRPL48;GFM1;MRPL39;EXOC3;MRPS26;IFT27
Transcriptional activation of mitochondrial biogenesisGABPA;C10orf2;TFB1M;MTERF;POLG2;POLRMT;PPRC1;GABPB1

PPRC1 has several biochemical functions, for example, RNA binding, RNA polymerase II transcription cofactor activity, ligand-dependent nuclear receptor transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPRC1 itself. We selected most functions PPRC1 had, and list some proteins which have the same functions with PPRC1. You can find most of the proteins on our site.

Function Related Protein
RNA bindingDHX36;SMARCE1;PRAC;DDX25;UMPS;EXOSC6;TRIM71;HNRNPH2;KHDC3L
RNA polymerase II transcription cofactor activityTP53BP1;CNOT2;MED19B;MED31;MED10;MED14;MED13B;TDG;NKX2-5
ligand-dependent nuclear receptor transcription coactivator activitySLC30A9;MED30;TADA3;MED14;RBM14;SRA1;SS18;PPRC1;HELZ2
nucleic acid bindingZFP354A;ZIC6;SCRT1B;HNRNPA1A;YY1A;RBPMS2;EGR2B;EIF4A1B;U2SURP
nucleotide bindingSTK38A;RHOAD;U2AF2;CELF5;RHOAE;SNRPA;CKMT2B;RBM14;JAK2B
poly(A) RNA bindingUBE2L3;PSMC1;DDX46;PRPF3;GAR1;ZNF385A;CCBL2;PIN4;PARP12
transcription factor bindingSUMO1;MYOCD;PPP1R13BB;TRIM11;TBX5;SMARCA4;PARK7;NFATC4;DIP2A

PPRC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPRC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPRC1.

Gab1

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