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PRDM4

Official Full Name

PR domain containing 4
Overview

The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF). This gene is located in a chromosomal region that is thought to contain tumor suppressor genes.
Synonyms

PRDM4; PR domain containing 4; PR domain zinc finger protein 4; PFM1; PR domain-containing protein 4; PR-domain zinc-finger protein PFM1; MGC45046;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Rhesus Macaque
Zebrafish

Source

HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	PRDM4-2885HCL	Recombinant Human PRDM4 293 Cell Lysate	HEK293	N/A	Inquiry
Mouse	PRDM4-13317M	Recombinant Mouse PRDM4 Protein	Mammalian Cell	His	Inquiry
Mouse	PRDM4-7067M	Recombinant Mouse PRDM4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	PRDM4-7067M-B	Recombinant Mouse PRDM4 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rat	PRDM4-4656R	Recombinant Rat PRDM4 Protein	Mammalian Cell	His	Inquiry
Rat	PRDM4-4315R	Recombinant Rat PRDM4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	PRDM4-4315R-B	Recombinant Rat PRDM4 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	PRDM4-3588R	Recombinant Rhesus monkey PRDM4 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	PRDM4-3406R-B	Recombinant Rhesus Macaque PRDM4 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	PRDM4-3406R	Recombinant Rhesus Macaque PRDM4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Zebrafish	PRDM4-6583Z	Recombinant Zebrafish PRDM4	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
PRDM4 Related Articles

PRDM4 involved in several pathways and played different roles in them. We selected most pathways PRDM4 participated on our site, such as Neurotrophin signaling pathway, Signal Transduction, Signalling by NGF, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDM4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Neurotrophin signaling pathway	IRAK1;CALML5;IRAK4;MAPK3;PIK3R3;MAPK13;MAGED1;IRAK2;ARHGDIB
Signal Transduction	RGS9BP;NRP2B;TRH;ARHGAP12B;EVC2;ARHGEF18A;NMBA;RDH13;DZIP1
Signalling by NGF	PRDM4;AATF;OMG;LINGO1;DNAL4;PCSK5;RTN4;ARHGEF1B;RIT1
p75 NTR receptor-mediated signalling	PRDM4;ARHGEF1B;RTN4;OMG;AATF;LINGO1;RTN4A;LINGO1B
p75(NTR)-mediated signaling	BEX1;MAGEH1;RTN4;ZNF274;OMG;RTN4R;NDN;PRDM4
p75NTR negatively regulates cell cycle via SC1

PRDM4 has several biochemical functions, for example, DNA binding, death receptor binding, histone methyltransferase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDM4 itself. We selected most functions PRDM4 had, and list some proteins which have the same functions with PRDM4. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	HIST1H2BJ;NR5A5;TGIF2LX;CXXC4;HIST2H2AA2;C3orf37;THRB;ZBTB6;POLE
death receptor binding	PRDM4;MYD88;RIPK1;Fasl;Casp3;NOL3;CFLAR;CASP8;FEM1B
histone methyltransferase binding	CBX1;NOP56;CBX3;PRDM4
methyltransferase activity	RG9MTD1;PRDM14;FAM86;METTL6;RG9MTD3;ZCCHC4;DNMT3;NTMT1;METTL4
protein binding	FZD2;PIFO;OLR1;RRM2B;NAGK;PPP1R12B;JAM3;REEP5;AGT
zinc ion binding	ZFAND3;ADAMTS5;SH3RF2;TRIM28;ZNF34;MMP16;MAN2B2;TRIM43A;ADAMTS15A

PRDM4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDM4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDM4.

MSRB3; CTNNBL1; EIF4E; SMAD3; msbA

Petukhova, NV; Gasanova, TV; et al. Immunogenicity and Protective Efficacy of Candidate Universal Influenza A Nanovaccines Produced in Plants by Tobacco Mosaic Virus-based Vectors. CURRENT PHARMACEUTICAL DESIGN 19:5587-5600(2013).

Dai, QS; Shah, AA; et al. A Truncated Progesterone Receptor (PR-M) Localizes to the Mitochondrion and Controls Cellular Respiration. MOLECULAR ENDOCRINOLOGY 27:741-753(2013).