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PRG4

  • Official Full Name

    proteoglycan 4

  • Overview

    The protein encoded by this gene is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    PRG4; proteoglycan 4; CACP, proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome); articular superficial zone protein; bG174L6.2; bG174L6.2 (MSF: megakaryocyte stimulating factor ); camptodactyly; arthropathy; coxa vara; pericarditis syndrome; FLJ32635; HAPO; Jacobs camptodactyly arthropathy pericarditis syndrome; JCAP; lubricin; megakaryocyte stimulating factor; MSF; SZP; Superficial zone proteoglycan; CACP; Camptodactyly arthropathy coxa vara pericarditis syndrome gene; Jacobs camptodactyly arthropathy pericarditis syndrome gene; PRG 4; Proteoglycan4; megakaryocyte-stimulating factor;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • CHO
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRG4-1573H Active Recombinant Human PRG4 CHO N/A
Human PRG4-1501H Recombinant Human PRG4, GST-tagged Wheat Germ GST
Human PRG4-361H Recombinant Human PRG4 protein, His-tagged E.coli His
Human Prg4-5499H Recombinant Human Prg4 protein, His-tagged Yeast His 25-156aa
Mouse PRG4-13339M Recombinant Mouse PRG4 Protein Mammalian Cell His
Mouse PRG4-7080M Recombinant Mouse PRG4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Prg4-1980M Recombinant Mouse Prg4 Protein, His&GST-tagged E.coli N-His&GST Gly797-Pro1054
Mouse PRG4-7080M-B Recombinant Mouse PRG4 Protein Pre-coupled Magnetic Beads HEK293
Mouse PRG4-132M Recombinant Mouse PRG4 protein (Met1-Pro1054), His-tagged HEK293 His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PRG4 Related Articles

PRG4 involved in several pathways and played different roles in them. We selected most pathways PRG4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PRG4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

PRG4 has several biochemical functions, for example, polysaccharide binding, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRG4 itself. We selected most functions PRG4 had, and list some proteins which have the same functions with PRG4. You can find most of the proteins on our site.

Function Related Protein
polysaccharide bindingMBL1;CLEC18C;VTN;PRG4A;TINAG;ENPP2;GM106;C8orf84;CLEC4G
scavenger receptor activityTMPRSS4B;CXCR7;LOXL4;LOXL3;LOXL3A;CD5L;PRSS12;CCBP2;SCARF1

PRG4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRG4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRG4.

Dlg4; GRB2; MYC

Ai, M; Cui, Y; et al. Anti-Lubricin Monoclonal Antibodies Created Using Lubricin-Knockout Mice Immunodetect Lubricin in Several Species and in Patients with Healthy and Diseased Joints. PLOS ONE 10:-(2015).
Steele, BL; Alvarez-Veronesi, MC; et al. Molecular weight characterization of PRG4 proteins using multi-angle laser light scattering (MALLS). OSTEOARTHRITIS AND CARTILAGE 21:498-504(2013).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can PRG4 be used as a treatment for osteoarthritis? 10/21/2022

Research is ongoing, but PRG4 is being investigated as a potential treatment for osteoarthritis due to its role in joint lubrication.

How does PRG4 contribute to joint health? 08/19/2022

PRG4 provides lubrication to joints, reducing friction between cartilage surfaces and helping to maintain joint health and function.

Can PRG4 be used to prevent joint degeneration? 03/01/2022

It may have the potential to slow down joint degeneration by improving joint lubrication, but more research is needed to confirm its preventive effects.

What are the clinical applications of PRG4 protein? 07/16/2016

PRG4 protein has several clinical applications, particularly in the field of orthopedics and rheumatology.

Are there any clinical trials involving PRG4 protein? 05/22/2016

Yes, there are clinical trials exploring the use of PRG4 in the treatment of joint-related disorders.

Customer Reviews (3)

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Reviews
01/26/2023

    With the PRG4 protein, researchers can confidently delve into the complexity of protein structures and gain deeper insights into their functions.

    02/12/2021

      the PRG4 protein's exceptional quality and purity guarantee its suitability for a wide range of experimental applications.

      08/22/2018

        Its versatility and reliability make it a great asset in the pursuit of scientific discoveries.

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