PRG4
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Official Full Name
proteoglycan 4
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Overview
The protein encoded by this gene is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PRG4; proteoglycan 4; CACP, proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome); articular superficial zone protein; bG174L6.2; bG174L6.2 (MSF: megakaryocyte stimulating factor ); camptodactyly; arthropathy; coxa vara; pericarditis syndrome; FLJ32635; HAPO; Jacobs camptodactyly arthropathy pericarditis syndrome; JCAP; lubricin; megakaryocyte stimulating factor; MSF; SZP; Superficial zone proteoglycan; CACP; Camptodactyly arthropathy coxa vara pericarditis syndrome gene; Jacobs camptodactyly arthropathy pericarditis syndrome gene; PRG 4; Proteoglycan4; megakaryocyte-stimulating factor;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- CHO
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | PRG4-1573H | Active Recombinant Human PRG4 | CHO | N/A | ||
Human | PRG4-1501H | Recombinant Human PRG4, GST-tagged | Wheat Germ | GST | ||
Human | PRG4-361H | Recombinant Human PRG4 protein, His-tagged | E.coli | His | ||
Human | Prg4-5499H | Recombinant Human Prg4 protein, His-tagged | Yeast | His | 25-156aa | |
Mouse | PRG4-13339M | Recombinant Mouse PRG4 Protein | Mammalian Cell | His | ||
Mouse | PRG4-7080M | Recombinant Mouse PRG4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Prg4-1980M | Recombinant Mouse Prg4 Protein, His&GST-tagged | E.coli | N-His&GST | Gly797-Pro1054 | |
Mouse | PRG4-7080M-B | Recombinant Mouse PRG4 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | PRG4-132M | Recombinant Mouse PRG4 protein (Met1-Pro1054), His-tagged | HEK293 | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- PRG4 Related Articles
PRG4 involved in several pathways and played different roles in them. We selected most pathways PRG4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PRG4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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PRG4 has several biochemical functions, for example, polysaccharide binding, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRG4 itself. We selected most functions PRG4 had, and list some proteins which have the same functions with PRG4. You can find most of the proteins on our site.
Function | Related Protein |
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polysaccharide binding | MBL1;CLEC18C;VTN;PRG4A;TINAG;ENPP2;GM106;C8orf84;CLEC4G |
scavenger receptor activity | TMPRSS4B;CXCR7;LOXL4;LOXL3;LOXL3A;CD5L;PRSS12;CCBP2;SCARF1 |
PRG4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRG4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRG4.
Dlg4; GRB2; MYC
- Q&As
- Reviews
Q&As (5)
Ask a questionResearch is ongoing, but PRG4 is being investigated as a potential treatment for osteoarthritis due to its role in joint lubrication.
PRG4 provides lubrication to joints, reducing friction between cartilage surfaces and helping to maintain joint health and function.
It may have the potential to slow down joint degeneration by improving joint lubrication, but more research is needed to confirm its preventive effects.
PRG4 protein has several clinical applications, particularly in the field of orthopedics and rheumatology.
Yes, there are clinical trials exploring the use of PRG4 in the treatment of joint-related disorders.
Customer Reviews (3)
Write a reviewWith the PRG4 protein, researchers can confidently delve into the complexity of protein structures and gain deeper insights into their functions.
the PRG4 protein's exceptional quality and purity guarantee its suitability for a wide range of experimental applications.
Its versatility and reliability make it a great asset in the pursuit of scientific discoveries.
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