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PRKAA2

  • Official Full Name

    protein kinase, AMP-activated, alpha 2 catalytic subunit

  • Overview

    The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a;heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important;energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is;activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy;beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and;cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin;sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
  • Synonyms

    PRKAA2; protein kinase, AMP-activated, alpha 2 catalytic subunit; PRKAA; 5-AMP-activated protein kinase catalytic subunit alpha-2; AMPK; AMPKa2; AMPK-alpha-2 chain; AMPK subunit alpha-2; 5-AMP-activated protein kinase, catalytic alpha-2 chain; AMPK2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Insect (sf21)
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRKAA2-79H Active Recombinant Human AMPK (A2/B1/G3), GST-His-tagged Sf9 Insect Cell GST/His
Human PRKAA2-60H Active Recombinant Human PRKAA2 (A2/B2/G3), GST-His-tagged Sf9 Insect Cell GST/His
Human PRKAA2-145H Active Recombinant Human PRKAA2/PRKAB2/PRKAG1, His-tagged E.coli His
Human PRKAA2-78H Active Recombinant Human AMPK (A2/B1/G2), GST-His-tagged Sf9 Insect Cell GST/His
Human PRKAA2-73H Recombinant Human PRKAA2, GST-tagged Sf9 Insect Cell GST/His
Human PRKAA2-105H Recombinant Human AMPK (combination of A2/B1/G1 subunits), His-tagged Sf9 Insect Cell His
Human PRKAA2-363H Recombinant Human PRKAA2 protein, His/MBP-tagged E.coli His/MBP 329-449 aa
Human PRKAA2-362H Recombinant Human PRKAA2 protein, His/MBP-tagged E.coli His/MBP 461-536 aa
Human PRKAA2-43H Recombinant Human AMPK (combination of A2/B2/G1 subunits), GST-His-tagged Sf9 Insect Cell GST/His
Human PRKAA2-364H Recombinant Human PRKAA2 protein, His/MBP-tagged E.coli His/MBP 252-321 aa
Human PRKAA2-44H Recombinant Human AMPK (combination of A2/B2/G2 subunits), GST-His-tagged Sf9 Insect Cell GST/His
Human PRKAA2-1413HCL Recombinant Human PRKAA2 cell lysate N/A
Human PRKAA2-1910HF Active Recombinant Full Length Human PRKAA2 Protein, GST-tagged Insect (sf21) GST 1-552(end)
Human PRKAA2-4496HF Active Recombinant Full Length Human PRKAA2 Protein, GST-tagged Insect (sf21) GST 1-552(end)
Human PRKAA2-5982H Recombinant Human PRKAA2 Protein (Met1-Arg552), N-His tagged E.coli N-His Met1-Arg552
Mouse PRKAA2-13349M Recombinant Mouse PRKAA2 Protein Mammalian Cell His
Mouse PRKAA2-7084M Recombinant Mouse PRKAA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PRKAA2-7084M-B Recombinant Mouse PRKAA2 Protein Pre-coupled Magnetic Beads HEK293
Rat PRKAA2-4669R Recombinant Rat PRKAA2 Protein Mammalian Cell His
Rat PRKAA2-4328R-B Recombinant Rat PRKAA2 Protein Pre-coupled Magnetic Beads HEK293
Rat PRKAA2-4328R Recombinant Rat PRKAA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken PRKAA2-3401C Recombinant Chicken PRKAA2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PRKAA2 Related Articles

PRKAA2 involved in several pathways and played different roles in them. We selected most pathways PRKAA2 participated on our site, such as FoxO signaling pathway, Regulation of autophagy, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FoxO signaling pathwayPRKAB1A;MAP2K2A;IL7R;STK11;S1PR1;MDM2;PTENB;MAPK12B;MAPK9
Regulation of autophagyIFNA7;INSB;IFNA1;ATG4A;ULK3;GABARAPL1;GABARAP;GABARAPL2;PRKAA2
mTOR signaling pathwayULK1;RRAGCB;TSC2;PRKCBA;BRAF;IRS1;RB1CC1;STK11;RRAGD
PIK-Akt signaling pathwayTP53;PPP2R3A;G6PC;EPO;MTOR;COL24A1;LAMA1;IFNA12;PDGFRB
AMPK signaling pathwayPPP2R5B;RAB8A;PPP2R2D;PFKM;CPT1B;PFKFB3;PRKAA1;PPP2R5D;PIK3CG
Circadian rhythmCRY2;PER2;SKP1;FBXW11;ARNTL;PRKAA1;RBX1;FBXL3;PRKAB2
Insulin signaling pathwayIRS1;SOCS4;PPP1CAB;CALM2;FBP2;CALM1A;CALM1B;PRKACAA;GRB2A
Adipocytokine signaling pathwayLEPR;ACSL1A;AKT2L;G6PC;JAK2;SLC2A1;TNFRSF1A;POMC;ADIPOQB
Oxytocin signaling pathwayCACNA2D2;CCND1;NRAS;CAMKK2;PRKAG3;GNAQ;PLA2G4C;CAMK4;NFATC2
Insulin resistanceSOCS3B;GFPT1;PRKAG3B;PTENB;SLC2A2;FOXO1A;CREB1A;INS1;PIK3R1
Non-alcoholic fatty liver disease (NAFLD)NDUFB3;NR1H3;IKBKB;COX8C;ATF4;SREBF1;CYCS;TGFB1;NDUFB4
Hypertrophic cardiomyopathy (HCM)TGFB3;ITGB4;MYL3;ACE;IL6;ITGA9;LMNA;TNF;ITGB3

PRKAA2 has several biochemical functions, for example, AMP-activated protein kinase activity, ATP binding, [acetyl-CoA carboxylase] kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAA2 itself. We selected most functions PRKAA2 had, and list some proteins which have the same functions with PRKAA2. You can find most of the proteins on our site.

Function Related Protein
AMP-activated protein kinase activityPRKAB1;PRKAA1;PRKAG3;ALPK2;PRKAG2;PRKAA2
ATP bindingTSSK3;IRAK3;IGF1RB;ABCG4B;PFKFB3;DGKAA;SGK3;IPMK;DNAJA2L
[acetyl-CoA carboxylase] kinase activityPRKAA1;PRKAA2
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activityPRKAA1;PRKAA2
chromatin bindingCHD7;ESR1;PBRM1;CREB3;POLR2B;STAT5B;CHAF1B;TWIST2;CDCA5
histone serine kinase activityPRKAA2;AURKB;ATM;PRKAA1;AURKC;AURKA
metal ion bindingHNRNPA0L;JAZF1B;RPS27A;CLEC4M;MAZ;PRICKLE2A;PDCD2;GMIP;GMPR2
protein bindingBCL2A1;CROP;LIN28B;EHD1;ZNF394;FAM195B;TCF7L2;RAB43;CDK8
protein kinase activitySOX9;SRPK1B;CCL2;MAPK12B;CDK9;PKDCCA;Aatk;RBM4.3;MAPK8A
protein serine/threonine kinase activityRPS6KA3;CAMKK1B;SRPK1B;STK4;AKT3A;AKT2;CLK3;RAF1A;MAP4K4
protein serine/threonine/tyrosine kinase activityPRKCG;ACVR2B;RPS6KA1;AURKB;SGK1;DYRK1AA;AURKC;TTK;DYRK2

PRKAA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAA2.

PRKAB2; PRKAG1; KIFC3; 386682

Bhavsar, SK; Schmidt, S; et al. AMPK alpha 1-Sensitivity of Orai1 and Ca2+ Entry in T-Lymphocytes. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 32:687-698(2013).
Voss, M; Paterson, J; et al. Ppm1E is an in cellulo AMP-activated protein kinase phosphatase. CELLULAR SIGNALLING 23:114-124(2011).
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