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PSEN1

  • Official Full Name

    presenilin 1

  • Overview

    Alzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
  • Synonyms

    PSEN1; presenilin 1; AD3; FAD; PS1; PS-1; S182; presenilin-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • C
  • Myc
  • DDK
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PSEN1-29963TH Recombinant Human PSEN1 Wheat Germ N/A 100 amino acids
Human PSEN1-2004H Recombinant Human PSEN1, His-tagged E.coli His 254-377aa
Human PSEN1-2790HCL Recombinant Human PSEN1 293 Cell Lysate HEK293 N/A
Human PSEN1-313H Recombinant Human PSEN1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Mouse PSEN1-13545M Recombinant Mouse PSEN1 Protein Mammalian Cell His
Mouse PSEN1-7201M Recombinant Mouse PSEN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Psen1-5171M Recombinant Mouse Psen1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PSEN1-7201M-B Recombinant Mouse PSEN1 Protein Pre-coupled Magnetic Beads HEK293
Rat PSEN1-4758R Recombinant Rat PSEN1 Protein Mammalian Cell His
Rat PSEN1-4417R Recombinant Rat PSEN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PSEN1-4417R-B Recombinant Rat PSEN1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PSEN1-3643R Recombinant Rhesus monkey PSEN1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PSEN1-3461R Recombinant Rhesus Macaque PSEN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PSEN1-3461R-B Recombinant Rhesus Macaque PSEN1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PSEN1-8653Z Recombinant Zebrafish PSEN1 Mammalian Cell His
Chicken PSEN1-5738C Recombinant Chicken PSEN1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PSEN1 Related Articles
  • PSEN1 Related Research Area
  • PSEN1 Related Signal Pathway

PSEN1 involved in several pathways and played different roles in them. We selected most pathways PSEN1 participated on our site, such as Wnt signaling pathway, Notch signaling pathway, Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSEN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Wnt signaling pathwaySIAH1A;DVL1B;CCND1;SIAH1;APC;SFRP5;PLCB3;FZD3B;BTRC
Notch signaling pathwayNUMB;CTBP2A;HER12;LFNG;KAT2B;PSEN2;DTX1;DTX3L;NOTCH3
Neurotrophin signaling pathwayMAPKAPK2;NFKBIE;CALML3;NFKBIA;BAX;TP73;PIK3R2;SHC2;NGFRAP1
Alzheimers diseasePPP3CB;CALML3;NDUFS7;UQCRQ;NDUFA13;APAF1;PPP3CC;CAPN2;Atp5g2

PSEN1 has several biochemical functions, for example, PDZ domain binding, aspartic-type endopeptidase activity, beta-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSEN1 itself. We selected most functions PSEN1 had, and list some proteins which have the same functions with PSEN1. You can find most of the proteins on our site.

Function Related Protein
PDZ domain bindingLNX1;GIPC1;ATP2B4;TGFBR3;ATP2B3A;Apba1;DOCK4;CFTR;ARHGEF16
aspartic-type endopeptidase activityATP6AP2;ANK2B;BACE1;NRIP2;BACE2;PSEN2;PIP;REN;PSEN1
beta-catenin bindingAPC;GRIP1;C;CD2AP;TCF7;CHD8;CARM1;CXADR;CTNNA1
cadherin bindingVCL;PTPRM;NDRG1;JUPA;CDK5R1;MMP24;TBC1D2;FXYD5;P2RX4
calcium channel activityCACNA1SB;TRPC6A;PKD2L1;GPM6A;CACNA1BA;CACNA1SA;P2RX1;RYR1;ITPR1
endopeptidase activityPSMB9B;PSMB9A;KLK1B11;PSMB2;KLK1B1;PSMB6;MMP1A;PSMA3;ACE
protein bindingHNRNPU;HNRNPL;ACTN2;TAF9B;KLF12;DDX17;ZC3H11A;SORBS2;NDUFAF3

PSEN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSEN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSEN1.

APBA1; NCSTN; APP; JUP; PKP4

Reinert, J; Martens, H; et al. A beta(38) in the Brains of Patients with Sporadic and Familial Alzheimer's Disease and Transgenic Mouse Models. JOURNAL OF ALZHEIMERS DISEASE 39:871-881(2014).
Irwin, DJ; Cohen, TJ; et al. Acetylated Tau Neuropathology in Sporadic and Hereditary Tauopathies. AMERICAN JOURNAL OF PATHOLOGY 183:344-351(2013).
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