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PTGDR2

  • Official Full Name

    prostaglandin D2 receptor 2

  • Overview

    This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3 UTR of this gene have been associated with asthma susceptibility.
  • Synonyms

    PTGDR2; prostaglandin D2 receptor 2; G protein coupled receptor 44 , GPR44; putative G-protein coupled receptor 44; CD294; chemoattractant receptor homologous molecule expressed on T helper type 2 cells; CRTH2; DP2; CD294 antigen; Chemoattractant receptor homologous molecule expressed on Th2 cells; Chemoattractant receptor-homologous molecule expressed on Th2 cells; CRTH 2; DL1R; G Protein Coupled Receptor 44; GPR 44; Gpr44; GPR44_HUMAN; Putative G protein coupled receptor 44; G protein-coupled receptor 44;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Protein Conjugation
  • His
  • His (Fc)
  • Avi
  • Flag
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTGDR2-932H Recombinant Human PTGDR2 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human PTGDR2-1135HFL Recombinant Human PTGDR2 protein, His&Flag-tagged HEK293 His&Flag 1-395 aa
Human PTGDR2-2812H Recombinant Human PTGDR2 Protein, His-tagged, OVA Conjugated Protein Conjugation N-His Asp329-Ala348
Rat PTGDR2-4803R Recombinant Rat PTGDR2 Protein Mammalian Cell His
Rat PTGDR2-4462R Recombinant Rat PTGDR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PTGDR2-4462R-B Recombinant Rat PTGDR2 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL19244HF Recombinant Full Length Human Prostaglandin D2 Receptor 2(Ptgdr2) Protein, His-Tagged E.coli expression system His Full Length (1-395)
Rattus norvegicus (Rat) RFL26992RF Recombinant Full Length Rat Prostaglandin D2 Receptor 2(Ptgdr2) Protein, His-Tagged E.coli expression system His Full Length (1-403)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTGDR2 Related Research Area

PTGDR2 involved in several pathways and played different roles in them. We selected most pathways PTGDR2 participated on our site, such as Class A/1 (Rhodopsin-like receptors), Eicosanoid ligand-binding receptors, G alpha (i) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGDR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)SSTR4;CCR6;OPN4A;GPR132;PTGDR2;EDN1;TAC3;LPAR5A;PROK2
Eicosanoid ligand-binding receptorsCYSLTR1;OXER1;LTB4R;GPR17;PTGDR2
G alpha (i) signalling eventsRGS20;CHRM2;ADRA2C;SOUL4;RGR;GPR55A;NMU;SSTR4;OPN1MW
GPCR downstream signalingCHRM5;TAE1;RGS1;TAC3;ADRA2C;CRHB;GPR17;EDNRB;ADM
GPCR ligand bindingOPN1SW;CNR2;TRH;RXFP2;RAMP1;APLNR;OPN1LW2;CALCB;NPFF
GPCRs, Class A Rhodopsin-likeGPR18;GPR1;OPN1SW;DRD4;CNR1;CNR2;LTB4R;OPN4;CCRL2
Prostanoid ligand receptors
Signal TransductionCNR2;ARHGAP8;IQCE;MDK;APOC2;GPR31;OXTRL;PTGDR2;RGS10

PTGDR2 has several biochemical functions, for example, G-protein coupled receptor activity, neuropeptide binding, prostaglandin D receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGDR2 itself. We selected most functions PTGDR2 had, and list some proteins which have the same functions with PTGDR2. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor activityOLFCS2;GHRHRA;GPR52;MAS1;TACR1A;GPR176;FZD3B;COR1;CXCR4
neuropeptide bindingSSTR1;OPRD1B;OPRL1;OPRK1;PTGDR2;NPY8AR;NPBWR2;SSTR5;NPY8BR
prostaglandin D receptor activityPTGDR;PTGDR2
prostaglandin F receptor activityPTGDR2;PTGER1C;PTGFR
prostaglandin J receptor activityPTGDR;PTGDR2

PTGDR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGDR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGDR2.

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