PTPRR
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Official Full Name
protein tyrosine phosphatase, receptor type, R
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Overview
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011] -
Synonyms
PTPRR; protein tyrosine phosphatase, receptor type, R; PTPRQ; EC-PTP; PCPTP1; PTP-SL; PTPBR7; receptor-type tyrosine-protein phosphatase R; R-PTP-R; NC-PTPCOM1; ch-1PTPase; Ch-1 PTPase; protein-tyrosine phosphatase PCPTP1; protein tyrosine phosphatase Cr1PTPase; protein-tyrosine phosphatase NC-PTPCOM1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rattus norvegicus (Rat)
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
PTPRR involved in several pathways and played different roles in them. We selected most pathways PTPRR participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | RAC1A;MYCB;FGF12A;PRKACG;Fasl;FLNB;ATF4B1;ARRB2;FGF20B |
PTPRR has several biochemical functions, for example, protein binding, protein kinase binding, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRR itself. We selected most functions PTPRR had, and list some proteins which have the same functions with PTPRR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | STX18;DNAIC2;CSF2RA;HOMER2;CIR1;COX5B;MEAF6;BBS9;SSNA1 |
| protein kinase binding | CD226;AXIN2;BAG5;ILK;FBXW5;HSP90AB1;TUBB3;TMEM173;RAD9 |
| protein tyrosine phosphatase activity | CDC14A;PGP;PTPN9;PTPN2B;PTPRM;LRP8;MDP1;PTPRNA;PTP4A2B |
| transmembrane receptor protein tyrosine phosphatase activity | PTPRF;PTPRG;PTPRS;PTPN6;PTPRO;PTPRR;PTPRA;PTPRD;PTPRUB |
PTPRR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRR here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRR.
MAPK1; MAPK14; PDGFRB; CDH2
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