PTS
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Official Full Name
6-pyruvoyltetrahydropterin synthase
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Overview
The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. -
Synonyms
PTS; 6-pyruvoyltetrahydropterin synthase; 6-pyruvoyl tetrahydrobiopterin synthase; PTPS; 6 pyruvoyl tetrahydrobiopterin synthase; 6 pyruvoyl tetrahydropterin synthase; 6 pyruvoyltetrahydropterin synthase; EC 4.2.3.12; FLJ97081; OTTHUMP00000235385; PTP synthase; PTPS_HUMAN;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- PTS Related Articles
PTS involved in several pathways and played different roles in them. We selected most pathways PTS participated on our site, such as Folate biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Folate biosynthesis | DHFR;QDPR;FPGS;PTS;MOCS2;GGH;ALPI.2;ALPPL2;QDPRA |
| Metabolic pathways | NDUFS1;MAN2A2;UGCG;MTMR7;HADHAB;HMBSA;PAFAH1B1A;UGT2A2;MGAT5B |
PTS has several biochemical functions, for example, 6-pyruvoyltetrahydropterin synthase activity, identical protein binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTS itself. We selected most functions PTS had, and list some proteins which have the same functions with PTS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 6-pyruvoyltetrahydropterin synthase activity | |
| identical protein binding | TRP63;ITGB3;SIRT1;SETX;IRF3;VIL1;LUC7L;ORAI1;CLDN20 |
| metal ion binding | ZNF10;COPS5;NSF;ZFP609;RBM4.2;HEPHL1A;TRIM105;NEURL1AB;CSRP1B |
| protein binding | PAAF1;MAGI1;MRPL40;CWC15;MAP3K11;IPO11;LPAR1;FBXO28;MAP3K8 |
| protein homodimerization activity | ASNSD1;IKBKG;ANO6;ADRA2A;ANG;P2RX7;TESCA;TERFA;MAP3K9 |
PTS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTS here. Most of them are supplied by our site. Hope this information will be useful for your research of PTS.
SDCBP; COIL; LNX1; THAP10; FXR2
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