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Pcx

Official Full Name

Podocalyxin
Overview

Podocalyxin, a sialoglycoprotein, is thought to be the major constituent of the glycocalyx of podocytes. It is a member of the CD34 family of transmembrane sialomucins. It coats the secondary foot processes of the podocytes. It is negatively charged and thus functions to keep adjacent foot processes separated, thereby keeping the urinary filtration barrier open. This function is further supported by knockout studies in mice which reveal an essential role in podocyte morphogenesis. Podocalyxin is also upregulated in a number of cancers and is frequently associated with poor prognosis. Sialylated, O-glycosylated glycoforms of podocalyxin expressed by colon carcinoma cells possess L-selectin and E-selectin binding activity, and may be pivotal to the metastatic spread of colon carcinoma cells.
Synonyms

PCX; Podocalyxin;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Mouse	Pcx-4723M	Recombinant Mouse Pcx Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry

Pcx involved in several pathways and played different roles in them. We selected most pathways Pcx participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Pcx were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

Pcx has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Pcx itself. We selected most functions Pcx had, and list some proteins which have the same functions with Pcx. You can find most of the proteins on our site.

Function	Related Protein

Pcx has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pcx here. Most of them are supplied by our site. Hope this information will be useful for your research of Pcx.