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SCO2

  • Official Full Name

    SCO cytochrome oxidase deficient homolog 2

  • Overview

    Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX asembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy.
  • Synonyms

    SCO2; SCO cytochrome oxidase deficient homolog 2 (yeast); SCO (cytochrome oxidase deficient, yeast) homolog 2; protein SCO2 homolog, mitochondrial; SCO1L; cytochrome oxidase deficient homolog 2; MGC125823; MGC125825;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human Sco2-170H Recombinant Human SCO2 E.coli N/A
Human SCO2-3449H Recombinant Human SCO2 protein, His-tagged E.coli His
Human SCO2-2025HCL Recombinant Human SCO2 293 Cell Lysate HEK293 N/A
Human SCO2-2836H Recombinant Human SCO2 Protein (Gly42-Ser266), His tagged E.coli His Gly42-Ser266
Human SCO2-3149H Recombinant Human SCO2 protein, His-tagged E. coli His 1-266 aa
Human SCO2-3473H Recombinant Human SCO2 protein, His-SUMO-tagged E.coli His-SUMO 43-266aa
Mouse SCO2-14770M Recombinant Mouse SCO2 Protein Mammalian Cell His
Mouse SCO2-7942M-B Recombinant Mouse SCO2 Protein Pre-coupled Magnetic Beads HEK293
Mouse SCO2-7942M Recombinant Mouse SCO2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish SCO2-4247Z Recombinant Zebrafish SCO2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SCO2 Related Articles

SCO2 involved in several pathways and played different roles in them. We selected most pathways SCO2 participated on our site, such as Central carbon metabolism in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Central carbon metabolism in cancerMET;PDHA1;RAF1;TRP53;IDH1;PIK3CD;PIK3CB;MAP2K1;HK3

SCO2 has several biochemical functions, for example, copper ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCO2 itself. We selected most functions SCO2 had, and list some proteins which have the same functions with SCO2. You can find most of the proteins on our site.

Function Related Protein
copper ion bindingLOX;LOXL4;LOXL3B;GPC1;ATOX1;ATP7B;HEPHL1;PRNPA;AOC2
protein bindingAPOBEC1;CCDC13;TIFA;FAM176B;DSCAM;DYRK2;CSE1L;ACSF2;SNCG

SCO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SCO2.

MAP3K3; MYC; 1C; PHKG2; MAGEA10; Prkacb; ILK; ARMC6; P

Coenen, MJH; van den Heuvel, LP; et al. Cytochrome c oxidase biogenesis in a patient with a mutation in COX10 gene. ANNALS OF NEUROLOGY 56:560-564(2004).
Takahashi, Y; Kako, K; et al. Mammalian copper chaperone Cox17p has an essential role in activation of cytochrome c oxidase and embryonic development. MOLECULAR AND CELLULAR BIOLOGY 22:7614-7621(2002).
Jaksch, M; Paret, C; et al. Cytochrome c oxidase deficiency due to mutations in SCO2, encoding a mitochondrial copper-binding protein, is rescued by copper in human myoblasts. HUMAN MOLECULAR GENETICS 10:3025-3035(2001).
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