SGCA
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Official Full Name
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
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Overview
This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SGCA; sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein); ADL, sarcoglycan, alpha (50kD dystrophin associated glycoprotein); alpha-sarcoglycan; 50kD DAG; A2; adhalin; adhalin (limb girdle muscular dystrophy 2D); DMDA2; LGMD2D; Sarcoglycan; alpha (50kD dystrophin associated glycoprotein; adhalin); SCARMD1; 50DAG; 59kDa; ADL; DAG2; 50 DAG; 50 kDa dystrophin associated glycoprotein; 50 kDa dystrophin-associated glycoprotein; Alpha SG; Alpha-SG; Asg; Dystroglycan 2; Dystroglycan-2; sarcoglycan, alpha (dystrophin-associated glycoprotein); SGCA_HUMAN; OTTHUMP00000221051; OTTHUMP00000221052; OTTHUMP00000221053; 50-DAG;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Mus musculus (Mouse)
- E.coli
- E.coli expression system
- E.Coli or Yeast
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- His
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | SGCA-27337TH | Recombinant Human SGCA | Wheat Germ | N/A | 108 amino acids | |
Human | SGCA-1890HCL | Recombinant Human SGCA 293 Cell Lysate | HEK293 | N/A | ||
Human | SGCA-1669H | Recombinant Human SGCA protein, His & GST-tagged | E.coli | His/GST | Gln24~His387 (Accession # Q16586) | |
Human | SGCA-02H | Recombinant Human SGCA Protein, Myc/DDK-tagged | HEK293 | Myc/DDK | ||
Human | SGCA-01H | Recombinant Human SGCA Protein, Myc/DDK-tagged | HEK293 | Myc/DDK | ||
Human | SGCA-3498H | Recombinant Human SGCA protein, His-tagged | E.coli | His | 24-105 aa | |
Human | SGCA-545HFL | Recombinant Full Length Human SGCA Protein, C-Flag-tagged | Mammalian cells | Flag | ||
Human | SGCA-1994H-B | Recombinant Human SGCA Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | SGCA-1994H | Recombinant Human SGCA Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | SGCA-15028M | Recombinant Mouse SGCA Protein | Mammalian Cell | His | ||
Mouse | Sgca-3387M | Recombinant Mouse Sgca, His-tagged | E.Coli or Yeast | His | 387 | |
Mouse | SGCA-8095M-B | Recombinant Mouse SGCA Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | Sgca-5820M | Recombinant Mouse Sgca Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Mouse | SGCA-8095M | Recombinant Mouse SGCA Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mus musculus (Mouse) | RFL18226MF | Recombinant Full Length Mouse Alpha-Sarcoglycan(Sgca) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (24-387) |
- Involved Pathway
- Protein Function
- Interacting Protein
- SGCA Related Research Area
SGCA involved in several pathways and played different roles in them. We selected most pathways SGCA participated on our site, such as Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, which may be useful for your reference. Also, other proteins which involved in the same pathway with SGCA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Hypertrophic cardiomyopathy (HCM) | PRKAA2;ITGA8;CACNG3;TPM4;SGCB;PRKAB1;ACE;PRKAB2;SGCA |
Arrhythmogenic right ventricular cardiomyopathy (ARVC) | EMD;CACNG6;CACNG2;AASS;JUP;ITGA4;ITGA8;ACTN3;ITGAV |
Dilated cardiomyopathy | LAMA2;CACNB1;ITGB5;ITGB1;ITGA3;RYR2;PRKACG;ACTG1;ITGB6 |
Viral myocarditis | PRF1;SGCB;CD86;EIF4G2;RAC2;CD40;H2-Q10;HLA-DOA;SGCG |
SGCA has several biochemical functions, for example, calcium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SGCA itself. We selected most functions SGCA had, and list some proteins which have the same functions with SGCA. You can find most of the proteins on our site.
Function | Related Protein |
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calcium ion binding | MMP15;FSTL5;SLIT1B;KIAA0494;MAN1A1;BNIP2;CLSTN1;PADI4;DSG2.1 |
protein binding | SPRR2A;NOL9;FAT4;STK3;ARID5A;KIAA0368;FAM50B;PHF23;ACVR2A |
SGCA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SGCA here. Most of them are supplied by our site. Hope this information will be useful for your research of SGCA.
SGTA; FN1; TAF1; FSTL1; ITGB1BP2
- Q&As
- Reviews
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