SHC1
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Official Full Name
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
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Synonyms
SHC1; SHC (Src homology 2 domain containing) transforming protein 1; SHC, SHC (Src homology 2 domain containing) transforming protein 1; SHC-transforming protein 1; p66; SH2 domain protein C1; SHC-transforming protein 3; SHC-transforming protein A; SHC (Src homology 2 domain-containing) transforming protein 1; SHC; SHCA; FLJ26504;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- SHC1 Related Research Area
- SHC1 Related Signal Pathway
SHC1 involved in several pathways and played different roles in them. We selected most pathways SHC1 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ErbB signaling pathway | NRG1;RAF1;MAP2K4;MAP2K2B;MAP2K4A;CBLB;MAPK8;GRB2;BADB |
| Ras signaling pathway | PLCG2;PLA2G5;PDGFB;KSR1;SOS1;Pdgfa&Pdgfb;CDC42;FGF22;RALGDS |
| Chemokine signaling pathway | CCL24;CCL4L2;GNG4;GM1987;CCL23;CRK;GNG8;BRAF;IKBKG |
| Phospholipase D signaling pathway | SPHK1;GRM4;CXCR2;INS1;TSC2;AGPAT5;MAPK1;RAF1;PIK3R1 |
| Focal adhesion | ITGB4;ZYX;RAC1;LAMB2;FLNA;VAV3B;TNC;PPP1R12C;RHOAD |
| Natural killer cell mediated cytotoxicity | PRKCA;IFNA10;TNFRSF10D;RAC3;NFATC2;BID;PIK3R3;SHC3;IFNGR2 |
| Neurotrophin signaling pathway | PDPK1;IRAK2;MAPK8;BRAF;IKBKB;IRAK4;CALM3;MAPK11;RAC1 |
| Insulin signaling pathway | PRKAG3;BAD;CALM4;SHC3;PYGB;FBP1A;PPP1CAB;PTPN1;CALM1 |
| Estrogen signaling pathway | CALM1;PLCB2;PRKACA;MMP2;GABBR2;GRB2;SP1;SRC;Adcy4 |
| Prolactin signaling pathway | CCND2;PIK3R1;MAPK11;MAPK10;MAPK13;SHC3;MAPK12;CSN2;TNFSF11 |
| Alcoholism | HIST1H4I;HIST1H2AM;GNG8;H2AFX;H2AFY2;GM14478;HIST1H4M;HIST1H4K;HIST1H3F |
| Bacterial invasion of epithelial cells | CBLB;CDH1;MET;CAV2;CRK;SEPT11;CBLC;ELMO3;PXN |
| MicroRNAs in cancer | PIK3R2;CDCA5;TRP63;DDIT4;SPRY2;SLC45A3;MAPK1;GLS2;HMOX1 |
| Glioma | CALM1;CALML5;GRB2;PLCG1;TP53;PTEN;CALM2;TRP53;PDGFB |
| Chronic myeloid leukemia | BRAF;RELA;BCR;ABL1;PIK3R1;BCL2L1;SHC2;CRK;ARAF |
SHC1 has several biochemical functions, for example, ephrin receptor binding, epidermal growth factor receptor binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHC1 itself. We selected most functions SHC1 had, and list some proteins which have the same functions with SHC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ephrin receptor binding | EFNA5;EFNA1B;EPHA4;EFNB1;CRK;EFNA5B;SDCBP;EPHA7;EFNB2 |
| epidermal growth factor receptor binding | GRB2;HBEGFA;SNX2;ATXN2;AGR2;LINGO1;VAV3;SOCS5;AREG |
| insulin receptor binding | PIK3R1;IGF1R;DOK7;PTPN1;FRS2B;PTPN11;INS1;INS2;INS |
| insulin-like growth factor receptor binding | PIK3R1;INSL4;IGF3;GNAS;Ren1;INSR;SOCS1;SHC1;YWHAH |
| neurotrophin TRKA receptor binding | SHC1;NGFR;GRB2;PLCG1;PIK3R1;EFNA5;FRS2 |
| phospholipid binding | NSMAF;LPAR3;SERPINB1A;F3;APOA1;NSFL1C;SPTBN1;TICAM2;SYTL4 |
| phosphotyrosine binding | SAMSN1;MAPK3;GRB2;ACP2;CBL;STAP1;MAPK1;SHC1;FGR |
| protein binding | MBD1;APC2;HHIPL2;EFTUD2;ARF1;KRT80;RRAGD;KCND2;SRSF11 |
| protein kinase binding | CACNB2;GYS1;BCAR1;HSPB1;AXIN1;TPRKB;AKAP5;FGFR1OP;BAD |
| protein phosphatase 2A binding | TRP53;IGBP1;ENSAA;SHC1;BCL2;SMG7;STRN4;TP53;PTPN1 |
| protein tyrosine kinase activity | MATK;TEK;EPHA2A;SRC;DYRK4;PTK6B;EGFRA;SYK;PTK2B |
| transmembrane receptor protein tyrosine kinase adaptor activity | TRAT1;GAB2;FRS2;BLNK;STAP1;SH2B2;PIK3R1;IRS1;SHC1 |
SHC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SHC1.
GRB2
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