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SNRPN

  • Official Full Name

    small nuclear ribonucleoprotein polypeptide N

  • Overview

    The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5 untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5 UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure.
  • Synonyms

    SNRPN; small nuclear ribonucleoprotein polypeptide N; Prader Willi syndrome chromosome region , PWCR; small nuclear ribonucleoprotein-associated protein N; HCERN3; RT LI; SM protein N; SM D; small nuclear ribonucleoprotein N; SMN; SNRNP N; SNURF SNRPN; tissue specific splicing protein; RTLI; Sm N; Small nuclear ribonucleoprotein associated protein N; SMD; SNRNPN; sm protein D; tissue-specific splicing protein; tissue-specific-splicing protein; PWCR; SM-D; sm-N; RT-LI; SNRNP-N; SNURF-SNRPN;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SNRPN-1610HCL Recombinant Human SNRPN 293 Cell Lysate HEK293 N/A
Human SNRPN-1609HCL Recombinant Human SNRPN 293 Cell Lysate HEK293 N/A
Human SNRPN-1658HCL Recombinant Human SNRPN cell lysate N/A
Human SNRPN-3253H Recombinant Human SNRPN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse SNRPN-15701M Recombinant Mouse SNRPN Protein Mammalian Cell His
Mouse SNRPN-8542M Recombinant Mouse SNRPN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Snrpn-6010M Recombinant Mouse Snrpn Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SNRPN-8542M-B Recombinant Mouse SNRPN Protein Pre-coupled Magnetic Beads HEK293
Rat SNRPN-5649R Recombinant Rat SNRPN Protein Mammalian Cell His
Rat SNRPN-5308R Recombinant Rat SNRPN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SNRPN-5308R-B Recombinant Rat SNRPN Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SNRPN-4384R Recombinant Rhesus monkey SNRPN Protein, His-tagged Mammalian Cell His
Rhesus Macaque SNRPN-4200R Recombinant Rhesus Macaque SNRPN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SNRPN-4200R-B Recombinant Rhesus Macaque SNRPN Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SNRPN Related Articles

SNRPN involved in several pathways and played different roles in them. We selected most pathways SNRPN participated on our site, such as Gastric cancer network 2, mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNRPN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Gastric cancer network 2CEBPZ;RAD17;LBR;SNURF;SNRPN;DSCC1;CHTF18;TOP2A;BRIX1
mRNA processingSPOP;HNRNPA2B1;CLK2;ZFP740;SF3A3;QK;HNRPL;PSKH1;CLASRP

SNRPN has several biochemical functions, for example, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNRPN itself. We selected most functions SNRPN had, and list some proteins which have the same functions with SNRPN. You can find most of the proteins on our site.

Function Related Protein
poly(A) RNA bindingDNAJC2;MRPS31;HNRPLL;UBE2I;CDK13;DIAP1;RPL3;ANP32A;CNOT4
protein bindingFAM195A;TBX6;MZT1;PPEF1;NFAT5;CD79B;DGKZ;WDHD1;TNPO2

SNRPN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNRPN here. Most of them are supplied by our site. Hope this information will be useful for your research of SNRPN.

POP7; Smn; CD2BP2; Dlg4; Rpp20; 17999537; PRPF3; HTATSF1; SF3B1

Fulmer-Smentek, SB; Francke, U; et al. Association of acetylated histones with paternally expressed genes in the Prader-Willi deletion region. HUMAN MOLECULAR GENETICS 10:645-652(2001).
Gray, TA; Smithwick, MJ; et al. Concerted regulation and molecular evolution of the duplicated SNRPB '/B and SNRPN loci. NUCLEIC ACIDS RESEARCH 27:4577-4584(1999).
LEFF, SE; BRANNAN, CI; et al. MATERNAL IMPRINTING OF THE MOUSE SNRPN GENE AND CONSERVED LINKAGE HOMOLOGY WITH THE HUMAN PRADER-WILLI SYNDROME REGION. NATURE GENETICS 2:259-264(1992).
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