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SP1

  • Official Full Name

    Sp1 transcription factor

  • Overview

    The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  • Synonyms

    SP1; Sp1 transcription factor; transcription factor Sp1; specificity protein 1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HeLa
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • C
  • His
  • GST
  • HA|Flag
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SP1-1158H Active Recombinant Human Sp1 Transcription Factor, His-tagged Sf9 Insect Cell His
Human SP1-1157H Active Recombinant Human Sp1 Transcription Factor HeLa N/A
Human SP1-8511H Active Recombinant Human SP1, GST-tagged E.coli GST
Human SP1-2093H Active Recombinant Human SP1, HA & Flag-tagged Insect Cell HA/Flag
Human SP1-1159H Active Recombinant Human Sp1 Transcription Factor, GST-tagged E.coli GST
Human SP1-30608TH Recombinant Human SP1 E.coli N/A
Human SP1-590H Recombinant Human Sp1 Transcription Factor Sf9 Insect Cell N/A
Human SP1-30987TH Recombinant Human SP1, His-tagged E.coli His
Human SP1-16H Recombinant Human SP1 protein, His-tagged E.coli His
Human SP1-6339H Recombinant Human SP1 Protein (Leu260-Ala591), N-His tagged E.coli N-His Leu260-Ala591
Human SP1-113H Recombinant Human SP1 Protein, His-tagged E.coli His
Human SP1-1956H Recombinant Human SP1 protein, His & GST-tagged E.coli His/GST Leu260~Ala591
Human SP1-2587H Recombinant Human SP1 protein(581-660 aa), C-His-tagged E. coli C-His 581-660 aa
Human SP1-98HFL Recombinant Full Length Human SP1 Protein, N-His-tagged E.coli His
Rat SP1-5677R Recombinant Rat SP1 Protein Mammalian Cell His
Rat SP1-5336R Recombinant Rat SP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SP1-5336R-B Recombinant Rat SP1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SP1-4417R Recombinant Rhesus monkey SP1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SP1-4233R Recombinant Rhesus Macaque SP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SP1-4233R-B Recombinant Rhesus Macaque SP1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SP1-11938Z Recombinant Zebrafish SP1 Mammalian Cell His
Chicken SP1-6172C Recombinant Chicken SP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SP1 Related Articles

SP1 involved in several pathways and played different roles in them. We selected most pathways SP1 participated on our site, such as TGF-beta signaling pathway, Estrogen signaling pathway, Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
TGF-beta signaling pathwayTFDP1;ID2A;AMHR2;ACVR1L;TGIF1;ACVR2AA;CUL1A;NOG2;TGFB3
Estrogen signaling pathwayGABBR1;GABBR2;ITPR3;ATF6B;GNAI1;CALM1;PIK3R3;HSPA1L;SHC3
Huntingtons diseaseHIP1;TGM2;COX6C;NDUFB6;POLR2I;ATP5C1;TRP53;NDUFB8;ATP5O
Transcriptional misregulation in cancerPLAU;ATM;PTCRA;SSX1;RUNX1T1;TAF15;ELK4;LRP2BP;TSPAN7
Choline metabolism in cancerMAP2K2;PCYT1A;HIF1A;MAPK1;CHKA;PPAP2A;SLC44A1;HRAS;MAPK9

SP1 has several biochemical functions, for example, DNA binding, HMG box domain binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SP1 itself. We selected most functions SP1 had, and list some proteins which have the same functions with SP1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZNF266;TMPO;NPAS2;HNRPDL;THAP6;IRX5A;NKX1.2LB;ZFP653;ZFPM2
HMG box domain bindingMEOX1;PRRX1;HHEX;ALX4;HOXA3;HOXC4;OLIG2;UTF1;JUN
RNA polymerase II core promoter proximal region sequence-specific DNA bindingMTF1;H2AFZ;TCF3A;EBF1;CEBPZ;PHOX2B;CREB1;TP73;MXD1
RNA polymerase II core promoter sequence-specific DNA bindingTP53;H2AFY;TAL1;TBR1;IRF7;NR4A2;HEYL;GATA6;EGR1
RNA polymerase II regulatory region sequence-specific DNA bindingZIK1;CEBPB;ZFP551;ELF5;ZFP39;LEF1;HSF2;ARHGAP35;PHF21B
RNA polymerase II repressing transcription factor bindingDMAP1;MIXL1;SIN3A;BBS7;SP1;PROL1;PPARA;BBS10;GATA6
RNA polymerase II transcription factor activity, sequence-specific DNA bindingSIM1A;MEF2D;MEF2C;FOXC1B;JUNBB;FLI1A;HIF1AL2;ATF4;FOXB1A
bHLH transcription factor bindingUSF2;SOX9;PSMD9;TCF3A;TCF21;SMAD3;TCF12;TCF3;TWIST1
core promoter sequence-specific DNA bindingRORA;ZFP932;PPARG;ZFHX3;MYOCD;SP1;TRP53;CHD2;TP53
double-stranded DNA bindingKIN;RAD51L1;KLF6;GATA1A;SP8B;TDP1;SETMAR;APTX;IFI203
enhancer bindingELL3;SP1;SMAD2;MESP1;FOXH1;SOX9;LEF1;TCF3;SMAD3
histone acetyltransferase bindingPCNA;TRIP4;MTF1;TP53;MEF2A;CITED2;SIRT2;EPAS1;CEBPB
histone deacetylase bindingRUNX2;MAGEA2;HDAC4;NCOR1;PRDM1;NKX3-1;HIF1A;NR2E1;MEF2D
metal ion bindingPLD6;ZNF26;SUMF2;ACVRL1;PAPD7;CMC1;GUCA1D;DDX59;ZNF324
protein C-terminus bindingFIGN;NIPBL;TRP53;SIRT1;DGKZ;TAX1BP3;ERCC4;PLEKHB1;RAD51
protein bindingACLY;LRRC4C;SDHAF2;CRX;TCP1;ITM2C;MAPK14;UBXN8;PDZK1
protein homodimerization activityPDGFB;SLC14A2;NFKB1;ACTN2;HEYL;TESC;CHMP3;TRIM5;S100A5
sequence-specific DNA bindingZNF75D;IRX3A;RARAA;NKX2.4A;BHLHE22;THRA;MKXA;LHX4;FOXJ1B
transcription factor activity, sequence-specific DNA bindingTCF3A;TRP63;GABPB1;NFE2L3;DLX3;HOXB3;KLF6;RBPJ;TARDBP
transcription factor bindingHDAC5;PAXBP1;HMGA1-RS1;PRICKLE1;RB1;GTF2A2;PPP1R13BB;MED6;NFKBIA
transcription regulatory region DNA bindingRELA;RFX6;TRP53;RCOR1;H2AFY2;ZNF649;CBX4;MTERFD1;SOX7
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingGABPA;ALS2CR8;ETV4;NRF1;HOXA5;NOBOX;TBX20;TRP53;HNRNPK

SP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SP1.

POU2F1; STAT3; HCFC1; SREBF2; tf65_human_gc-box3_dna-probe

Wang, YD; Rajanbabu, V; et al. Transcriptome analysis of medaka following epinecidin-1 and TH1-5 treatment of NNV infection. FISH & SHELLFISH IMMUNOLOGY 42:121-131(2015).
Shen, L; Kapsogeorgou, EK; et al. Evaluation of salivary gland protein 1 antibodies in patients with primary and secondary Sjogren's syndrome. CLINICAL IMMUNOLOGY 155:42-46(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does SP1 affect immune response? 07/30/2022

SP1 plays a role in immune response by regulating the expression of genes involved in inflammation and immune cell function. Its modulation can influence the immune system's response to various stimuli.

Does SP1 have a role in cardiovascular diseases? 11/27/2020

Yes, SP1 is implicated in cardiovascular diseases by regulating genes involved in vascular smooth muscle cell proliferation and migration. Targeting SP1 may offer therapeutic avenues for cardiovascular conditions.

Is SP1 involved in neurodegenerative diseases? 10/25/2019

Yes, SP1 has been implicated in neurodegenerative diseases. Its role in regulating genes related to neuronal survival and death makes it a target for exploring therapeutic interventions in conditions like Alzheimer's disease.

Can SP1 protein be used as a diagnostic marker for cancer? 03/18/2019

Yes, elevated levels of SP1 have been observed in certain cancers. Detection of SP1 expression can potentially serve as a diagnostic marker, aiding in the early identification of cancer.

How does SP1 contribute to angiogenesis? 10/15/2017

SP1 regulates the expression of genes involved in angiogenesis, the formation of new blood vessels. Increased SP1 activity is associated with enhanced angiogenesis, which can be critical in wound healing and tumor growth.

Customer Reviews (3)

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Reviews
11/25/2020

    In addition to their expertise, the manufacturer's technical support team can assist in troubleshooting and optimizing the handling and application of the SP1 protein.

    02/25/2019

      Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various disciplines.

      09/25/2017

        By relying on the SP1 protein and the manufacturer's exceptional technical support, researchers can confidently pursue their experimental goals while knowing they have access to reliable resources and expert guidance.

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