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WIBG

Official Full Name

within bgcn homolog
Overview

Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.
Synonyms

WIBG; within bgcn homolog (Drosophila); partner of Y14 and mago; PYM; protein wibg homolog; MGC13064;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	WIBG-30861TH	Recombinant Human WIBG, His-tagged	E.coli	His	204 amino acids	Inquiry
Human	WIBG-2771H	Recombinant Human Within Bgcn Homolog (Drosophila), His-tagged	E.coli	His		Inquiry
Human	WIBG-312HCL	Recombinant Human WIBG 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	WIBG-18548M	Recombinant Mouse WIBG Protein	Mammalian Cell	His		Inquiry
Mouse	WIBG-10180M-B	Recombinant Mouse WIBG Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	WIBG-10180M	Recombinant Mouse WIBG Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	WIBG-5215R	Recombinant Rhesus monkey WIBG Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	WIBG-5028R	Recombinant Rhesus Macaque WIBG Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	WIBG-5028R-B	Recombinant Rhesus Macaque WIBG Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	WIBG-10872Z	Recombinant Zebrafish WIBG	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

WIBG involved in several pathways and played different roles in them. We selected most pathways WIBG participated on our site, such as RNA transport, mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WIBG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
RNA transport	PNN;MAGOHB;RBM8A;EIF2S1B;SUMO2;NUP62L;THOC2;POP1;POP7
mRNA surveillance pathway	BCL2L2-PABPN1;PPP2R5D;PPP2R5A;GSPT1L;PPP1CC;PNN;PPP2R5EA;PPP2CB;HBS1L

WIBG has several biochemical functions, for example, poly(A) RNA binding, protein binding, ribosome binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WIBG itself. We selected most functions WIBG had, and list some proteins which have the same functions with WIBG. You can find most of the proteins on our site.

Function	Related Protein
poly(A) RNA binding	TBRG4;SARS2;PKN2;LIN28B;MRPS12;EIF4E;RPS15A;LUZP4;C1orf131
protein binding	NUP37;DVL3;FAM120B;NOA1;RARRES3;SKAP2;FLVCR1;RAB11FIP2;PYGO2
ribosome binding	MTRF1L;EIF5A;EIF2S1B;YTHDF1;CPEB3;EIF2S1;CPEB1B;RPN2;CPEB2

WIBG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WIBG here. Most of them are supplied by our site. Hope this information will be useful for your research of WIBG.

RBM8A; MAGOH; b2r9y1_human; icp27_hhv8p