XIAP
-
Official Full Name
X-linked inhibitor of apoptosis
-
Overview
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011] -
Synonyms
XIAP; X-linked inhibitor of apoptosis; API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3; E3 ubiquitin-protein ligase XIAP; X-linked IAP; IAP-like protein; inhibitor of apoptosis protein 3; baculoviral IAP repeat-containing protein 4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- Avi
- C
- His
- Flag
- GST
- GST|StrepII
- His (Fc)
- His|StrepII
- His|T7
- SUMO
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- XIAP Related Articles
- XIAP Related Research Area
XIAP involved in several pathways and played different roles in them. We selected most pathways XIAP participated on our site, such as NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with XIAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NF-kappa B signaling pathway | TRAF5;CCL19;TRAF2;BCL10;MAP3K7IP3;BTK;TNFSF11;CCL4;PLCG1 |
| Ubiquitin mediated proteolysis | ERCC8;NEDD4L;UBE2S;UBE1Y1;MGRN1A;UBE3B;PARK2;FBXW11B;UBE2G1B |
| Apoptosis | CASP3A;PRKACA;HIST1H1B;CASP6L1;HIST1H1A;DIABLO;CAPN1A;CASP8;PIK3R3A |
| Focal adhesion | COL1A1A;PAK1;COL6A4;ITGB6;LAMA5;THBS3A;VTNB;MET;MYLK3 |
| Toxoplasmosis | ITGB1;LAMC1;MAP2K6;Toxoplasma Gondii Major Surface Antigen P30;NFKBIA;PIK3R2;HSPA1L;H2-AA;AKT2 |
| HTLV-I infection | PTTG1;MAP3K14;PDGFRB;RB1;CDC27;FZD8;MYBL1;NFKB2;SPI1 |
| Pathways in cancer | FGF9;Flt3l;PIK3CG;PTK2;SUFU;WNT7A;PTCH1;BAX;ARAF |
| Small cell lung cancer | ITGB1;AKT1;BIRC7;TRAF1;TRAF6;LAMA2;LAMB3;XIAP;LAMA5 |
XIAP has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XIAP itself. We selected most functions XIAP had, and list some proteins which have the same functions with XIAP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | BIRC3;GAS6;PRDX3;DPEP1;NOL3;LEF1;BIRC2;ARRB1;CD27 |
| ligase activity | XIAP;UBR7;TRIML2;RNF146;KCMF1;NAPRT;KCNG4;TMEM129;TTLL9 |
| protein binding | AGO1;RBM22;RAMP1;SOX10;MYLK;GYS1;TRPC5;GSTO1;NOL4 |
| ubiquitin protein ligase activity | RNF24;HERC4;UBE2V1;TMEM189;TRIM6;NEDD4L;C12orf51;CCNB1IP1;UBE2H |
| ubiquitin-protein transferase activity | UBE2A;UBR1;UBE3C;RNF146;MALT1;RNF151;SMURF1;RNF144B;ANAPC4 |
| zinc ion binding | NR2F6A;SEC23A;ING5;SUV39H1;MAN2A2;ZZEF1;DDX58;TRIM23;TRIP6 |
XIAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XIAP here. Most of them are supplied by our site. Hope this information will be useful for your research of XIAP.
CASP9; HTRA2
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, mutations in XIAP are associated with X-linked lymphoproliferative syndrome type 2 (XLP-2), a rare immunodeficiency disorder.
Yes, several clinical trials are investigating XIAP-targeted therapies for cancer, autoimmune diseases, and immunodeficiency disorders.
XIAP inhibitors are being explored as potential treatments for cancer to sensitize cancer cells to apoptosis-inducing therapies.
XIAP can be targeted using small molecule inhibitors and gene therapy to modulate apoptosis in various diseases.
Dysregulation of XIAP has been associated with autoimmune diseases, and its modulation may be a therapeutic strategy in such conditions.
Customer Reviews (3)
Write a reviewWith their assistance, I am confident in overcoming challenges, producing robust results, and advancing our understanding of XIAP protein and its biological significance.
In addition to the impeccable protein quality, the manufacturer provides excellent technical support that can effectively address any challenges I may encounter during my experiments.
The technical support provided by the manufacturer is invaluable in resolving any potential roadblocks and optimizing the utilization of XIAP protein.
Ask a Question for All XIAP Products
Required fields are marked with *
My Review for All XIAP Products
Required fields are marked with *
